Protein: HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1 (EC 2.3.2.27) (HMG-CoA reductase degradation protein 1) (RING-type E3 ubiquitin transferase HRD1)

Gene: HRD1
Organism: Saccharomyces cerevisiae S288C
Interactions: 73
UniProt ID: Q08109

Gene Ontology (top 5):
GO:0000836 - Hrd1p ubiquitin ligase complex
GO:0000838 - Hrd1p ubiquitin ligase ERAD-M complex
GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

993385

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

16

16

Small-scale

0.986

High

969240

UBC7
Ubiquitin-conjugating enzyme E2 7

16

20

Small-scale

0.986

High

549841

UBC4
Ubiquitin-conjugating enzyme E2 4

2

20

Small-scale

0.778

High

984792

HRD3
ERAD-associated E3 ubiquitin-protein ligase component HRD3

14

5

Small-scale

0.762

High

477469

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

3

18

Small-scale

0.756

High

636763

CDC48
Cell division control protein 48

10

12

Small-scale

0.756

High

520366

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

6

4

Small-scale

0.739

High

600938

UBC1
Ubiquitin-conjugating enzyme E2 1

1

20

Small-scale

0.724

High

979137

UBX2
UBX domain-containing protein 2

8

0

Small-scale

0.720

High

977376

USA1
U1 SNP1-associating protein 1

8

0

Small-scale

0.720

High

993388

OS9
Protein OS-9 homolog

7

0

Small-scale

0.713

High

748215

DER1
Degradation in the endoplasmic reticulum protein 1

6

0

Small-scale

0.702

High

341107

CBPY
Carboxypeptidase Y

6

0

Small-scale

0.696

High

707253

NPL4
Nuclear protein localization protein 4

3

1

Small-scale

0.664

High

703560

UBC6
Ubiquitin-conjugating enzyme E2 6

1

20

Small-scale

0.647

High

858709

UFD1
Ubiquitin fusion degradation protein 1

2

3

Small-scale

0.624

High

492627

HSP71
Heat shock protein SSA1

3

14

High-throughput

0.624

High

993387

DFM1
DER1-like family member protein 1

2

8

Small-scale

0.611

High

366989

HSP82
ATP-dependent molecular chaperone HSP82

2

12

High-throughput

0.588

High

544515

HSC82
ATP-dependent molecular chaperone HSC82

2

12

High-throughput

0.588

High

681045

HS104
Heat shock protein 104

2

3

High-throughput

0.588

High

495120

HSP72
Heat shock protein SSA2

2

14

High-throughput

0.571

High

797106

OTU1
Ubiquitin thioesterase OTU1

1

3

Small-scale

0.569

High

520293

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

4

Small-scale

0.536

High

696083

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.536

High

334542

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

6

High-throughput

0.515

High

410463

SC160
Protein SCP160

1

3

High-throughput

0.515

High

440924

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

1

High-throughput

0.515

High

485845

IF4A
ATP-dependent RNA helicase eIF4A

1

6

High-throughput

0.515

High

549766

STI1
Heat shock protein STI1

1

6

High-throughput

0.515

High

562292

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

3

High-throughput

0.515

High

643701

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.515

High

665085

BMH1
Protein BMH1

1

8

High-throughput

0.515

High

696474

FIMB
Fimbrin

1

3

High-throughput

0.515

High

777104

SYA
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.515

High

991307

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.515

High

341732

HIS2
Histidine biosynthesis trifunctional protein [Includes: Phosphoribosyl-AMP cyclohydrolase

1

0

High-throughput

0.493

High

404379

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.493

High

425047

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.493

High

549279

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.493

High

549633

KCY
Uridylate kinase

1

0

High-throughput

0.493

High

555763

THRC
Threonine synthase

1

0

High-throughput

0.493

High

679725

CYS3
Cystathionine gamma-lyase

1

0

High-throughput

0.493

High

798046

DUG1
Cys-Gly metallodipeptidase DUG1

1

0

High-throughput

0.493

High

866908

IDHH
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.493

High

976933

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.493

High

993386

SPEE
Spermidine synthase SPE3

1

0

High-throughput

0.493

High

750095

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

1

0

Small-scale

0.480

High

560811

BIP
Endoplasmic reticulum chaperone BiP

1

12

Small-scale

0.479

High

586210

PMA2
Plasma membrane ATPase 2

1

5

High-throughput

0.479

High

597013

ACO1
Acyl-CoA desaturase 1

1

1

Small-scale

0.479

High

679940

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

3

Small-scale

0.479

High

703967

PRS7
26S proteasome regulatory subunit 7 homolog

1

12

Small-scale

0.479

High

707522

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

3

Small-scale

0.479

High

334993

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

6

High-throughput

0.470

High

561077

EF3A
Elongation factor 3A

1

1

High-throughput

0.470

High

687494

EF2
Elongation factor 2

1

2

High-throughput

0.470

High

692947

SPT16
FACT complex subunit SPT16

1

1

High-throughput

0.470

High

857281

ACS2
Acetyl-coenzyme A synthetase 2

1

3

High-throughput

0.470

High

625849

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

Small-scale

0.458

High

991714

HBT1
Protein HBT1

1

0

High-throughput

0.458

High

704077

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

1

Small-scale

0.457

High

450211

HSP73
Heat shock protein SSA3

1

14

High-throughput

0.445

High

512963

SSB1
Ribosome-associated molecular chaperone SSB1

1

14

High-throughput

0.445

High

695656

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

705732

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

766243

HSP7E
Heat shock protein SSC3, mitochondrial

1

14

High-throughput

0.445

High

769637

SSB2
Ribosome-associated molecular chaperone SSB2

1

14

High-throughput

0.445

High

985287

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

18

High-throughput

0.445

High

628528

SIS1
Protein SIS1

1

6

High-throughput

0.407

High

754383

RPP1
Ribonuclease P/MRP protein subunit RPP1

1

0

High-throughput

0.269

Low

979858

POB3
FACT complex subunit POB3

1

0

High-throughput

0.269

Low


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Last updated: 15 Jul 2024