Protein: KU80
ATP-dependent DNA helicase II subunit 2 (EC 3.6.4.12) (ATP-dependent DNA helicase II subunit Ku80) (High affinity DNA-binding factor subunit 2) (Yeast Ku80)

Gene: KU80, YKU80
Organism: Saccharomyces cerevisiae S288C
Interactions: 142
UniProt ID: Q04437

Gene Ontology (top 5):
GO:0000723 - telomere maintenance
GO:0000724 - double-strand break repair via homologous recombination
GO:0000725 - recombinational repair
GO:0000781 - chromosome, telomeric region
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

698524

KU70
ATP-dependent DNA helicase II subunit 1

12

8

Small-scale

0.975

High

979551

NEJ1
Non-homologous end-joining protein 1

2

1

Small-scale

0.768

High

516912

SIR4
Regulatory protein SIR4

5

1

Small-scale

0.722

High

566227

EST1
Telomere elongation protein EST1

3

1

Small-scale

0.640

High

979558

DNLI4
DNA ligase 4

1

6

Small-scale

0.621

High

565764

PHO85
Cyclin-dependent protein kinase PHO85

2

7

Small-scale

0.619

High

902052

H3
Histone H3

2

7

Small-scale

0.584

High

372833

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

1

High-throughput

0.536

High

423703

ADR1
Regulatory protein ADR1

1

2

High-throughput

0.536

High

628441

SIS1
Protein SIS1

1

3

High-throughput

0.536

High

691242

MKK2
MAP kinase kinase MKK2/SSP33

1

5

High-throughput

0.536

High

728314

DEF1
RNA polymerase II degradation factor 1

1

3

High-throughput

0.536

High

753047

RRP3
ATP-dependent rRNA helicase RRP3

1

6

High-throughput

0.536

High

760813

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.536

High

762021

DHH1
ATP-dependent RNA helicase DHH1

1

6

High-throughput

0.536

High

766197

HSP7E
Heat shock protein SSC3, mitochondrial

1

3

High-throughput

0.536

High

772931

TCPE
T-complex protein 1 subunit epsilon

1

3

High-throughput

0.536

High

962627

ACAC
Acetyl-CoA carboxylase

1

2

High-throughput

0.536

High

607336

RFA1
Replication factor A protein 1

1

5

Small-scale

0.534

High

554736

HSP26
Heat shock protein 26

2

3

High-throughput

0.533

High

644775

RFA2
Replication factor A protein 2

1

5

Small-scale

0.515

High

440917

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.513

High

592977

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.513

High

622895

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.513

High

689447

YBT1
ATP-dependent bile acid permease

1

0

High-throughput

0.513

High

748482

SLX1
Structure-specific endonuclease subunit SLX1

1

0

High-throughput

0.513

High

752104

YHJ3
Uncharacterized protein YHR033W

1

0

High-throughput

0.513

High

812018

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.513

High

979562

TFC7
Transcription factor tau 55 kDa subunit

1

0

High-throughput

0.513

High

342108

ATPB
ATP synthase subunit beta, mitochondrial

1

6

High-throughput

0.500

High

366861

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.500

High

381483

GAL1
Galactokinase

1

1

High-throughput

0.500

High

423910

ATPA
ATP synthase subunit alpha, mitochondrial

1

6

High-throughput

0.500

High

424704

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.500

High

440094

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.500

High

498593

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.500

High

556288

VATB
V-type proton ATPase subunit B

1

6

High-throughput

0.500

High

570722

HXKG
Glucokinase-1

1

1

High-throughput

0.500

High

588220

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.500

High

633555

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.500

High

636738

CDC48
Cell division control protein 48

1

4

High-throughput

0.500

High

715854

MDJ1
DnaJ homolog 1, mitochondrial

1

2

High-throughput

0.500

High

811456

TCPQ
T-complex protein 1 subunit theta

1

2

High-throughput

0.500

High

887670

ACT
Actin

1

1

High-throughput

0.500

High

968078

PRS8
26S proteasome regulatory subunit 8 homolog

1

1

High-throughput

0.500

High

979563

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.500

High

389982

VDAC1
Mitochondrial outer membrane protein porin 1

1

2

High-throughput

0.489

High

427295

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

1

High-throughput

0.489

High

549761

STI1
Heat shock protein STI1

1

3

High-throughput

0.489

High

560353

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

1

1

High-throughput

0.489

High

660935

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

1

High-throughput

0.489

High

763903

IF2P
Eukaryotic translation initiation factor 5B

1

2

High-throughput

0.489

High

774668

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

3

High-throughput

0.489

High

783347

LST8
Target of rapamycin complex subunit LST8

1

2

High-throughput

0.489

High

862345

SULX
Putative sulfate transporter YPR003C

1

1

High-throughput

0.489

High

863634

COPA
Coatomer subunit alpha

1

2

High-throughput

0.489

High

864682

NOG2
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.489

High

977164

CLU
Clustered mitochondria protein 1

1

2

High-throughput

0.489

High

977805

WDR59
Maintenance of telomere capping protein 5

1

3

High-throughput

0.489

High

698603

MRE11
Double-strand break repair protein MRE11

1

1

Small-scale

0.481

High

860445

RSC1
Chromatin structure-remodeling complex subunit RSC1

1

13

Small-scale

0.481

High

562433

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.479

High

979556

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.479

High

355631

H2B1
Histone H2B.1

1

10

High-throughput

0.479

High

356005

H2B2
Histone H2B.2

1

10

High-throughput

0.479

High

356705

H4
Histone H4

1

3

High-throughput

0.479

High

392196

H2A1
Histone H2A.1

1

9

High-throughput

0.479

High

392562

H2A2
Histone H2A.2

1

9

High-throughput

0.479

High

606752

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

692917

SPT16
FACT complex subunit SPT16

1

2

High-throughput

0.479

High

979553

TERT
Telomerase reverse transcriptase

1

3

Small-scale

0.479

High

979554

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

979564

CMR1
DNA damage-binding protein CMR1

1

7

High-throughput

0.479

High

979559

SMT3
Ubiquitin-like protein SMT3

1

3

Small-scale

0.470

High

979565

SUS1
Transcription and mRNA export factor SUS1

1

0

Small-scale

0.458

High

343687

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.457

High

361024

TBB
Tubulin beta chain

1

1

High-throughput

0.457

High

378397

LEU3
3-isopropylmalate dehydrogenase

1

3

High-throughput

0.457

High

397616

OTC
Ornithine carbamoyltransferase

1

1

High-throughput

0.457

High

453027

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.457

High

454452

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.457

High

454659

TBA3
Tubulin alpha-3 chain

1

2

High-throughput

0.457

High

604470

CLH
Clathrin heavy chain

1

1

High-throughput

0.457

High

619638

MPCP
Mitochondrial phosphate carrier protein

1

2

High-throughput

0.457

High

629041

SCJ1
DnaJ-related protein SCJ1

1

3

High-throughput

0.457

High

634191

SRO9
RNA-binding protein SRO9

1

3

High-throughput

0.457

High

767730

IMB4
Importin subunit beta-4

1

1

High-throughput

0.457

High

803414

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

2

High-throughput

0.457

High

867523

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

2

High-throughput

0.457

High

979560

HSP42
Heat shock protein 42

1

3

High-throughput

0.457

High

478504

HSP77
Import motor subunit, mitochondrial

1

3

High-throughput

0.445

High

492364

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

512646

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.445

High

519994

TCPA
T-complex protein 1 subunit alpha

1

2

High-throughput

0.445

High

695478

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

760950

TCPD
T-complex protein 1 subunit delta

1

3

High-throughput

0.445

High

663253

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

698934

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.437

High

336736

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.279

Low

417599

PHSG
Glycogen phosphorylase

1

0

High-throughput

0.279

Low

439564

GAL7
Galactose-1-phosphate uridylyltransferase

1

0

High-throughput

0.279

Low

576119

MET16
Phosphoadenosine phosphosulfate reductase

1

0

High-throughput

0.279

Low

604830

PSB4
Proteasome subunit beta type-4

1

0

High-throughput

0.279

Low

632503

PSB3
Proteasome subunit beta type-3

1

0

High-throughput

0.279

Low

691499

RPN12
26S proteasome regulatory subunit RPN12

1

0

High-throughput

0.279

Low

693663

SIP1
SNF1 protein kinase subunit beta-1

1

0

High-throughput

0.279

Low

696827

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.279

Low

704645

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.279

Low

733554

HFL1
Vacuole membrane protein HFL1

1

0

High-throughput

0.279

Low

743833

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

758706

TEM1
Protein TEM1

1

0

High-throughput

0.279

Low

761589

DSS1
Exoribonuclease II, mitochondrial

1

0

High-throughput

0.279

Low

767327

MRX1
MIOREX complex component 1

1

0

High-throughput

0.279

Low

809676

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.279

Low

828082

APT1
Adenine phosphoribosyltransferase 1

1

0

High-throughput

0.279

Low

847977

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.279

Low

861504

YG5L
Uncharacterized protein YGR266W

1

0

High-throughput

0.279

Low

863036

SUCA
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

961623

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.279

Low

976926

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.279

Low

977432

YMC0
Uncharacterized protein YML020W

1

0

High-throughput

0.279

Low

978580

TSA2
Peroxiredoxin TSA2

1

0

High-throughput

0.279

Low

979550

YM71
NADP-dependent 3-hydroxy acid dehydrogenase

1

0

High-throughput

0.279

Low

979552

YL271
Uncharacterized protein YLR271W

1

0

High-throughput

0.279

Low

979555

PUF3
mRNA-binding protein PUF3

1

0

High-throughput

0.279

Low

979557

AVO1
Target of rapamycin complex 2 subunit AVO1

1

0

High-throughput

0.279

Low

979561

PST2
Protoplast secreted protein 2

1

0

High-throughput

0.279

Low

368386

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.261

Low

421694

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.261

Low

521055

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.261

Low

549686

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.261

Low

576011

ADT2
ADP,ATP carrier protein 2

1

0

High-throughput

0.261

Low

630830

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.261

Low

665039

BMH1
Protein BMH1

1

0

High-throughput

0.261

Low

772734

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

785204

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.261

Low

979549

SOV1
Protein SOV1, mitochondrial

1

0

High-throughput

0.261

Low

419501

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.249

Low

977493

PML39
Pre-mRNA leakage protein 39

1

0

High-throughput

0.249

Low

978532

LRS4
Monopolin complex subunit LRS4

1

0

Small-scale

0.249

Low

440128

AAP
Arginine attenuator peptide

1

0

High-throughput

0.238

Low

866146

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024