Protein: ENO
Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase)

Gene: ENO
Organism: Drosophila melanogaster
Interactions: 215
UniProt ID: P15007

Gene Ontology (top 5):
GO:0000015 - phosphopyruvate hydratase complex
GO:0000287 - magnesium ion binding
GO:0004634 - phosphopyruvate hydratase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

578034

PPIA
Peptidyl-prolyl cis-trans isomerase

3

3

High-throughput

0.629

High

578057

TRXR1
Thioredoxin reductase 1, mitochondrial

3

4

High-throughput

0.629

High

578021

ENO
Enolase

1

13

Small-scale

0.575

High

57511

A1ZB71
Glutathione S transferase E6

2

1

High-throughput

0.571

High

358458

ADH
Alcohol dehydrogenase

2

2

High-throughput

0.571

High

446261

MLC1
Myosin light chain alkali

2

1

High-throughput

0.571

High

458074

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

2

9

High-throughput

0.571

High

459978

ALF
Fructose-bisphosphate aldolase

2

2

High-throughput

0.571

High

476896

NDKA
Nucleoside diphosphate kinase

2

1

High-throughput

0.571

High

578023

PCNA
Proliferating cell nuclear antigen

2

1

High-throughput

0.571

High

578026

MLR
Myosin regulatory light chain 2

2

1

High-throughput

0.571

High

578031

ANX10
Annexin B10

2

2

High-throughput

0.571

High

578036

PROF
Profilin

2

1

High-throughput

0.571

High

578040

UCHL
Ubiquitin carboxyl-terminal hydrolase

2

4

High-throughput

0.571

High

578045

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

2

2

High-throughput

0.571

High

578047

MOEH
Moesin/ezrin/radixin homolog 1

2

2

High-throughput

0.571

High

578048

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

2

4

High-throughput

0.571

High

578050

KARG
Arginine kinase 1

2

1

High-throughput

0.571

High

578052

PDI
Protein disulfide-isomerase

2

3

High-throughput

0.571

High

578054

SODC
Superoxide dismutase [Cu-Zn]

2

5

High-throughput

0.571

High

578060

PGK
Phosphoglycerate kinase

2

3

High-throughput

0.571

High

578071

NLP
Nucleoplasmin-like protein

2

2

High-throughput

0.571

High

578078

Q7JX87
1-Cys peroxiredoxin

2

2

High-throughput

0.571

High

578080

Q7K148
Proteasome subunit beta

2

3

High-throughput

0.571

High

578100

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

2

1

High-throughput

0.571

High

578116

THIO2
Thioredoxin-2

2

4

High-throughput

0.571

High

578120

Q9VAC4
GEO09167p1

2

2

High-throughput

0.571

High

578121

Q9VAN7
Phosphoglycerate mutase

2

3

High-throughput

0.571

High

578139

TCTP
Translationally-controlled tumor protein homolog

2

2

High-throughput

0.571

High

578141

Q9VHN7
transketolase

2

3

High-throughput

0.571

High

578145

Q9VIE8
Aconitate hydratase, mitochondrial

2

1

High-throughput

0.571

High

578150

EF1D
Probable elongation factor 1-delta

2

1

High-throughput

0.571

High

578157

Q9VPN5
Stress-induced-phosphoprotein 1

2

5

High-throughput

0.571

High

578161

Q9VRD6
NTF2-related export protein

2

1

High-throughput

0.571

High

578165

Q9VSL2
Glutathione S transferase O3

2

1

High-throughput

0.571

High

578169

Q9VTY2
Uncharacterized protein, isoform A

2

4

High-throughput

0.571

High

578172

Q9VUC1
Hsc70Cb, isoform A

2

3

High-throughput

0.571

High

578176

Q9VW59
Rho GDP-dissociation inhibitor 3

2

1

High-throughput

0.571

High

578187

Q9W227
Peptidyl-prolyl cis-trans isomerase

2

3

High-throughput

0.571

High

578197

PSA6
Proteasome subunit alpha type-6

2

5

High-throughput

0.571

High

194995

O16043
Anon1A4

2

0

High-throughput

0.547

High

357456

INO1
Inositol-3-phosphate synthase

2

0

High-throughput

0.547

High

567537

GPDA
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

2

0

High-throughput

0.547

High

578093

Q8IRD3
Glutathione peroxidase

2

0

High-throughput

0.547

High

578103

NACA
Nascent polypeptide-associated complex subunit alpha

2

0

High-throughput

0.547

High

578109

IF5A
Eukaryotic translation initiation factor 5A

2

0

High-throughput

0.547

High

578112

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

2

0

High-throughput

0.547

High

578113

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

2

0

High-throughput

0.547

High

578128

Q9VEB1
Malate dehydrogenase, mitochondrial

2

0

High-throughput

0.547

High

578154

Q9VLB7
Rab GDP dissociation inhibitor

2

0

High-throughput

0.547

High

578158

Q9VPX6
Adenylyl cyclase-associated protein

2

0

High-throughput

0.547

High

197722

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

2

2

High-throughput

0.521

High

356283

O97102
Small ubiquitin-related modifier

2

4

High-throughput

0.521

High

578062

ATPB
ATP synthase subunit beta, mitochondrial

2

1

High-throughput

0.521

High

578105

VDAC
Voltage-dependent anion-selective channel

2

1

High-throughput

0.521

High

578114

Q9V3V2
peptidylprolyl isomerase

2

4

High-throughput

0.521

High

578137

Q9VGK3
peptidylprolyl isomerase

2

4

High-throughput

0.521

High

578170

Q9VU35
10 kDa heat shock protein, mitochondrial

2

5

High-throughput

0.521

High

578184

Q9W022
GEO01508p1

2

5

High-throughput

0.521

High

578192

CISY
Probable citrate synthase, mitochondrial

2

1

High-throughput

0.521

High

57102

A1ZAU6
FI05912p

1

0

High-throughput

0.486

High

578027

SXL
Protein sex-lethal

1

0

High-throughput

0.486

High

578046

SCRT
Protein scarlet

1

0

High-throughput

0.486

High

578181

Q9VYK7
glutathione-specific gamma-glutamylcyclotransferase

1

0

High-throughput

0.486

High

578167

Q9VT68
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

1

1

High-throughput

0.481

High

304502

AUB
Protein aubergine

1

1

Small-scale

0.479

High

559785

EF2
Eukaryotic translation elongation factor 2

1

1

High-throughput

0.479

High

578022

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

4

Small-scale

0.479

High

578035

TUD
Protein tudor

1

2

Small-scale

0.479

High

578058

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

578069

MERH
Moesin/ezrin/radixin homolog 2

1

2

High-throughput

0.479

High

578089

Q86BM5
A kinase anchor protein 200, isoform D

1

4

High-throughput

0.479

High

578095

Q8IRS7
Ciboulot, isoform C

1

1

High-throughput

0.479

High

578130

Q9VEV3
Tetratricopeptide repeat protein 1

1

5

High-throughput

0.479

High

578138

Q9VGM2
Fatty acid-binding protein, muscle

1

1

High-throughput

0.479

High

578044

GSTS1
Glutathione S-transferase S1

1

0

High-throughput

0.458

High

578123

ATLAS
Atlastin

1

0

Small-scale

0.458

High

578173

PYRG
CTP synthase

1

0

High-throughput

0.458

High

578168

Q9VT69
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

1

1

High-throughput

0.457

High

53961

A1Z892
1-Cys peroxiredoxin

1

2

High-throughput

0.445

High

121169

ALDR
Aldo-keto reductase 1B

1

4

High-throughput

0.445

High

234534

VINC
Vinculin

1

1

High-throughput

0.445

High

357245

O97428
Ciboulot, isoform A

1

1

High-throughput

0.445

High

556629

PSA1
Proteasome subunit alpha type-1

1

4

High-throughput

0.445

High

561757

MODU
DNA-binding protein modulo

1

1

High-throughput

0.445

High

571699

MP20
Muscle-specific protein 20

1

2

High-throughput

0.445

High

578024

PSA4
Proteasome subunit alpha type-4

1

4

High-throughput

0.445

High

578025

ACTN
Alpha-actinin, sarcomeric

1

1

High-throughput

0.445

High

578030

ANXB9
Annexin B9

1

2

High-throughput

0.445

High

578032

PSA71
Proteasome subunit alpha type-7-1

1

3

High-throughput

0.445

High

578038

TPIS
Triosephosphate isomerase

1

4

High-throughput

0.445

High

578039

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

578042

PSA2
Proteasome subunit alpha type-2

1

5

High-throughput

0.445

High

578043

PSB1
Proteasome subunit beta type-1

1

4

High-throughput

0.445

High

578051

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

1

High-throughput

0.445

High

578065

MY61F
Unconventional myosin IC

1

3

High-throughput

0.445

High

578070

VATA2
V-type proton ATPase catalytic subunit A isoform 2

1

2

High-throughput

0.445

High

578072

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.445

High

578075

Q76NR6
Regucalcin

1

1

High-throughput

0.445

High

578077

Q7JVH6
LD24696p

1

4

High-throughput

0.445

High

578079

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

1

4

High-throughput

0.445

High

578082

Q7K3J0
T-complex protein 1 subunit theta

1

2

High-throughput

0.445

High

578085

TERA
Transitional endoplasmic reticulum ATPase TER94

1

4

High-throughput

0.445

High

578086

Q7KN85
ATP-citrate synthase

1

1

High-throughput

0.445

High

578091

Q8INK3
Fatty acid-binding protein, muscle

1

1

High-throughput

0.445

High

578092

Q8IQZ7
FI19014p1

1

3

High-throughput

0.445

High

578098

Q8MT58
Carnosine dipeptidase 2, isoform A

1

2

High-throughput

0.445

High

578099

Q8MYY7
RE44624p

1

3

High-throughput

0.445

High

578106

PSA5
Proteasome subunit alpha type-5

1

2

High-throughput

0.445

High

578117

PSA3
Proteasome subunit alpha type-3

1

5

High-throughput

0.445

High

578125

Q9VD02
GH14779p

1

1

High-throughput

0.445

High

578129

FLNA
Filamin-A

1

6

High-throughput

0.445

High

578134

TWF
Twinfilin

1

3

High-throughput

0.445

High

578144

Q9VHX4
LD24679p

1

4

High-throughput

0.445

High

578146

Q9VII9
Glyoxylate reductase/hydroxypyruvate reductase

1

1

High-throughput

0.445

High

578147

Q9VK60
GH25425p

1

1

High-throughput

0.445

High

578148

Q9VKB0
threonine--tRNA ligase

1

1

High-throughput

0.445

High

578153

FKB59
FK506-binding protein 59

1

4

High-throughput

0.445

High

578155

AK200
A-kinase anchor protein 200

1

5

High-throughput

0.445

High

578156

PSB4
Proteasome subunit beta type-4

1

7

High-throughput

0.445

High

578162

Q9VRL1
GEO06356p1

1

2

High-throughput

0.445

High

578177

Q9VWG1
LD37169p

1

3

High-throughput

0.445

High

578180

CLIC
Chloride intracellular channel Clic

1

1

High-throughput

0.445

High

578185

Q9W0H8
Reticulocalbin-3

1

2

High-throughput

0.445

High

578186

SND1
Staphylococcal nuclease domain-containing protein 1

1

2

High-throughput

0.445

High

578194

PSB3
Proteasome subunit beta type-3

1

3

High-throughput

0.445

High

578195

Q9XYZ9
Glutathione S transferase E12, isoform A

1

1

High-throughput

0.445

High

578199

PURA
Adenylosuccinate synthetase

1

1

High-throughput

0.445

High

578200

Q9Y112
BcDNA.GH10614

1

4

High-throughput

0.445

High

95392

E1JJ90
Meiosis-specific nuclear structural protein 1

1

1

High-throughput

0.439

High

578166

Q9VSW1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.438

High

120740

M9PE30
Transgelin

1

2

High-throughput

0.437

High

578094

Q8IRH7
Supercoiling factor variant B

1

2

High-throughput

0.437

High

578182

Q9VYR1
Regucalcin

1

1

High-throughput

0.437

High

57737

A1ZB77
Uncharacterized protein, isoform J

1

0

High-throughput

0.426

High

145948

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.426

High

197303

O18335
Rab11

1

0

High-throughput

0.426

High

305626

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.426

High

356529

O97121
cystathionine gamma-lyase

1

0

High-throughput

0.426

High

578029

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.426

High

578049

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.426

High

578053

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.426

High

578055

CALM
Calmodulin

1

0

High-throughput

0.426

High

578087

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

0

High-throughput

0.426

High

578088

Q7KTW5
Inositol-1-monophosphatase

1

0

High-throughput

0.426

High

578101

Q8T0L3
E1 ubiquitin-activating enzyme

1

0

High-throughput

0.426

High

578108

FAXC
Failed axon connections

1

0

High-throughput

0.426

High

578110

JUPIT
Microtubule-associated protein Jupiter

1

0

High-throughput

0.426

High

578111

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.426

High

578119

Q9VAC1
GM14349p

1

0

High-throughput

0.426

High

578124

Q9VCK6
LD34157p

1

0

High-throughput

0.426

High

578135

Q9VG31
Malic enzyme

1

0

High-throughput

0.426

High

578140

TEBPH
Cytosolic Prostaglandin E synthase

1

0

High-throughput

0.426

High

578143

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.426

High

578149

Q9VKW5
Prolyl endopeptidase

1

0

High-throughput

0.426

High

578164

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.426

High

578174

Y9705
Cold shock domain-containing protein CG9705

1

0

High-throughput

0.426

High

578188

Q9W2M4
Farnesoic acid O-methyl transferase domain-containing protein

1

0

High-throughput

0.426

High

578191

Q9W3Y3
Calcyclin-binding protein

1

0

High-throughput

0.426

High

578193

Q9W457
Serine hydroxymethyltransferase

1

0

High-throughput

0.426

High

578196

Q9XZ57
Eb1, isoform E

1

0

High-throughput

0.426

High

95702

E4NKJ7
Peptidyl-prolyl cis-trans isomerase

1

3

High-throughput

0.417

High

578133

Q9VFK2
Crossveinless c, isoform A

1

3

High-throughput

0.417

High

578142

Q9VHR7
Meiosis-specific nuclear structural protein 1

1

1

High-throughput

0.417

High

86450

B9EQV3
Endoplasmic reticulum transmembrane protein

1

2

High-throughput

0.407

High

426613

HP1
Heterochromatin protein 1

1

1

High-throughput

0.407

High

578028

TNNT
Troponin T, skeletal muscle

1

1

High-throughput

0.407

High

578033

PHB1
Prohibitin 1

1

3

High-throughput

0.407

High

578061

HMGD
High mobility group protein D

1

2

High-throughput

0.407

High

578063

Q0E924
Prohibitin

1

3

High-throughput

0.407

High

578073

Q3YMU0
Protein disulfide-isomerase

1

3

High-throughput

0.407

High

578118

Q9V9U3
LD45254p

1

2

High-throughput

0.407

High

578122

Q9VAY2
Heat shock protein 83

1

8

High-throughput

0.407

High

578126

Q9VD29
small monomeric GTPase

1

1

High-throughput

0.407

High

578159

Q9VQ61
Aspartate aminotransferase

1

1

High-throughput

0.407

High

578175

Q9VVL7
Dihydrolipoyl dehydrogenase

1

4

High-throughput

0.407

High

578183

Q9VZI1
Transgelin

1

2

High-throughput

0.407

High

578190

Q9W3X6
fumarate hydratase

1

3

High-throughput

0.407

High

578198

FL2D
Pre-mRNA-splicing regulator female-lethal(2)D

1

4

Small-scale

0.407

High

482724

TPM2
Tropomyosin-2

2

0

High-throughput

0.298

High

578037

CALR
Calreticulin

2

0

High-throughput

0.298

High

578059

SODM
Superoxide dismutase [Mn], mitochondrial

2

0

High-throughput

0.298

High

578067

ATP5J
ATP synthase-coupling factor 6, mitochondrial

2

0

High-throughput

0.298

High

578097

Q8MSI2
GH15296p

2

0

High-throughput

0.298

High

578115

Q9V3V9
Endonuclease G inhibitor, isoform A

2

0

High-throughput

0.298

High

578151

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

2

0

High-throughput

0.298

High

578152

Q9VL70
HL08109p

2

0

High-throughput

0.298

High

578160

BACC
Bacchus

2

0

High-throughput

0.298

High

54307

A1Z8H7
Cuticular protein 47Ef, isoform C

1

0

High-throughput

0.265

Low

578127

Q9VDC1
Deoxyribonuclease TATDN1

1

0

High-throughput

0.265

Low

578131

Q9VFA3
Uncharacterized protein, isoform A

1

0

High-throughput

0.265

Low

578107

Q95RF6
LD34461p

1

0

High-throughput

0.249

Low

578096

Q8MR61
GH11143p

1

0

High-throughput

0.238

Low

304591

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.232

Low

578041

TNNI
Troponin I

1

0

High-throughput

0.232

Low

578056

CYC2
Cytochrome c-2

1

0

High-throughput

0.232

Low

578064

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.232

Low

578066

ATP5H
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.232

Low

578068

ATPO
ATP synthase subunit O, mitochondrial

1

0

High-throughput

0.232

Low

578074

Q6IHY5
Cytochrome c oxidase subunit 7A-like 2, isoform A

1

0

High-throughput

0.232

Low

578076

Q7JUS9
Phosphate carrier protein, mitochondrial

1

0

High-throughput

0.232

Low

578081

Q7K2K2
FI04612p

1

0

High-throughput

0.232

Low

578083

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.232

Low

578084

NITO
RNA-binding protein spenito

1

0

Small-scale

0.232

Low

578090

Q8I062
GH23305p

1

0

High-throughput

0.232

Low

578102

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.232

Low

578104

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.232

Low

578132

Q9VFF0
Mitochondrial-processing peptidase subunit beta

1

0

High-throughput

0.232

Low

578136

Q9VG33
Sulfurtransferase

1

0

High-throughput

0.232

Low

578163

Q9VRP2
Uncharacterized protein, isoform A

1

0

High-throughput

0.232

Low

578171

NPLP2
Neuropeptide-like 2

1

0

High-throughput

0.232

Low

578178

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.232

Low

578179

SUN
Protein stunted

1

0

High-throughput

0.232

Low

578189

Q9W2X6
ATP synthase F(1) complex subunit delta, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025