Protein: TOP1
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme)

Gene: TOP1, topA
Organism: Escherichia coli K-12
Interactions: 70
UniProt ID: P06612

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003916 - DNA topoisomerase activity
GO:0003917 - DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0005694 - chromosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

415767

TOP3
DNA topoisomerase 3

2

1

High-throughput

0.789

High

415769

RECQ
ATP-dependent DNA helicase RecQ

2

10

High-throughput

0.789

High

415772

SRMB
ATP-dependent RNA helicase SrmB

2

2

High-throughput

0.789

High

415736

RL19
Large ribosomal subunit protein bL19

2

1

High-throughput

0.612

High

415734

SYL
Leucine--tRNA ligase

2

2

High-throughput

0.608

High

415771

HYAD
Hydrogenase 1 maturation protease

2

0

High-throughput

0.606

High

415738

RL33
Large ribosomal subunit protein bL33

2

1

High-throughput

0.588

High

415739

RS10
Small ribosomal subunit protein uS10

2

1

High-throughput

0.588

High

415757

RL13
Large ribosomal subunit protein uL13

2

1

High-throughput

0.588

High

415740

RS13
Small ribosomal subunit protein uS13

2

0

High-throughput

0.585

High

336953

PHSM
Maltodextrin phosphorylase

2

0

High-throughput

0.585

High

415784

RLUB
Ribosomal large subunit pseudouridine synthase B

2

0

High-throughput

0.585

High

415746

RPOZ
DNA-directed RNA polymerase subunit omega

2

0

High-throughput

0.563

High

415750

RPOB
DNA-directed RNA polymerase subunit beta

2

0

High-throughput

0.563

High

415788

RL2
Large ribosomal subunit protein uL2

2

0

High-throughput

0.563

High

415780

HOLC
DNA polymerase III subunit chi

1

1

High-throughput

0.561

High

415773

RECJ
Single-stranded-DNA-specific exonuclease RecJ

2

1

High-throughput

0.558

High

415744

RNH
Ribonuclease HI

2

1

High-throughput

0.537

High

343754

SYA
Alanine--tRNA ligase

1

2

High-throughput

0.536

High

356990

RS7
Small ribosomal subunit protein uS7

1

1

High-throughput

0.536

High

415743

RS5
Small ribosomal subunit protein uS5

1

1

High-throughput

0.536

High

415753

DLDH
Dihydrolipoyl dehydrogenase

1

1

High-throughput

0.536

High

415756

CSPC
Cold shock-like protein CspC

1

1

High-throughput

0.536

High

415782

RSMB
Ribosomal RNA small subunit methyltransferase B

1

1

High-throughput

0.536

High

415789

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.536

High

415796

HSCC
Chaperone protein HscC

1

3

High-throughput

0.536

High

415768

DNLJ
DNA ligase

1

0

High-throughput

0.518

High

415735

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.513

High

415748

TRPB
Tryptophan synthase beta chain

1

0

High-throughput

0.513

High

415751

YCIA
Acyl-CoA thioester hydrolase YciA

1

0

High-throughput

0.513

High

415752

RIMJ
[Ribosomal protein uS5]-alanine N-acetyltransferase

1

0

High-throughput

0.513

High

415754

GATD
Galactitol 1-phosphate 5-dehydrogenase

1

0

High-throughput

0.513

High

415770

PRLF
Antitoxin PrlF

1

0

High-throughput

0.513

High

415774

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase

1

0

High-throughput

0.513

High

415783

KDGK
2-dehydro-3-deoxygluconokinase

1

0

High-throughput

0.513

High

415785

IADA
Isoaspartyl dipeptidase

1

0

High-throughput

0.513

High

415786

RSTA
Transcriptional regulatory protein RstA

1

0

High-throughput

0.513

High

415797

RSXC
Ion-translocating oxidoreductase complex subunit C

1

0

High-throughput

0.513

High

415733

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

1

3

High-throughput

0.489

High

415755

YBIT
Probable ATP-binding protein YbiT

1

1

High-throughput

0.489

High

415737

RL28
Large ribosomal subunit protein bL28

1

1

High-throughput

0.484

High

415742

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.484

High

415761

DBHA
DNA-binding protein HU-alpha

1

2

High-throughput

0.484

High

415762

DBHB
DNA-binding protein HU-beta

1

2

High-throughput

0.484

High

415790

RL22
Large ribosomal subunit protein uL22

1

1

High-throughput

0.484

High

415741

RS20
Small ribosomal subunit protein bS20

1

0

High-throughput

0.464

High

415745

RPOA
DNA-directed RNA polymerase subunit alpha

1

0

High-throughput

0.464

High

415749

RPOC
DNA-directed RNA polymerase subunit beta'

1

0

High-throughput

0.464

High

415760

HOLE
DNA polymerase III subunit theta

1

0

High-throughput

0.464

High

415763

HNS
DNA-binding protein H-NS

1

0

High-throughput

0.464

High

415764

ROB
Right origin-binding protein

1

0

High-throughput

0.464

High

415794

KDGR
HTH-type transcriptional regulator KdgR

1

0

High-throughput

0.458

High

415766

SSB
Single-stranded DNA-binding protein

1

3

High-throughput

0.445

High

415758

ARTP
Arginine transport ATP-binding protein ArtP

1

2

High-throughput

0.442

High

415765

RPOE
ECF RNA polymerase sigma-E factor

1

0

High-throughput

0.438

High

415781

FLIH
Flagellar assembly protein FliH

1

0

High-throughput

0.438

High

415759

ATPA
ATP synthase subunit alpha

1

1

High-throughput

0.437

High

415747

TIG
Trigger factor

1

0

Small-scale

0.426

High

415787

NIFJ
Probable pyruvate-flavodoxin oxidoreductase

1

1

High-throughput

0.417

High

415779

YIGZ
IMPACT family member YigZ

2

0

High-throughput

0.318

High

367443

RBSB
Ribose import binding protein RbsB

1

0

High-throughput

0.282

High

415791

GNGF
Putative gluconeogenesis factor

1

0

High-throughput

0.282

High

415775

LPXM
Lipid A biosynthesis myristoyltransferase

1

0

High-throughput

0.279

Low

415776

GABP
Gamma-aminobutyric acid permease

1

0

High-throughput

0.279

Low

415777

RFAL
O-antigen ligase

1

0

High-throughput

0.279

Low

415778

GLND
Bifunctional uridylyltransferase/uridylyl-removing enzyme

1

0

High-throughput

0.279

Low

415792

MACA
Macrolide export protein MacA

1

0

High-throughput

0.279

Low

415795

FETA
Probable iron export ATP-binding protein FetA

1

0

High-throughput

0.279

Low

415798

YBER
Uncharacterized protein YbeR

1

0

High-throughput

0.279

Low

415793

FLGA
Flagella basal body P-ring formation protein FlgA

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024