Protein: SIR4
NAD-dependent protein deacylase Sirt4 (EC 2.3.1.286) (Regulatory protein SIR2 homolog 4)

Gene: SIR4, Sirt4
Organism: Drosophila melanogaster
Interactions: 34
UniProt ID: Q8IRR5

Gene Ontology (top 5):
GO:0003950 - NAD+ poly-ADP-ribosyltransferase activity
GO:0004407 - histone deacetylase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

814661

PHP
Polyhomeotic-proximal chromatin protein

1

11

High-throughput

0.508

High

1306666

Q9VFF0
Mitochondrial-processing peptidase subunit beta

1

7

High-throughput

0.508

High

1306671

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.508

High

1263129

Q7JXE4
GEO05123p1

1

0

High-throughput

0.486

High

1263747

Q7JZJ3
Cuticular protein 56F

1

2

High-throughput

0.464

High

1269738

Q7KUB3
Ecdysone-inducible gene E1, isoform A

1

2

High-throughput

0.464

High

1304190

Q8INT9
Uncharacterized protein, isoform A

1

2

High-throughput

0.464

High

1306661

ENA
Protein enabled

1

6

High-throughput

0.464

High

1306662

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

6

High-throughput

0.464

High

1306675

Q9W374
Dihydropyrimidine dehydrogenase [NADP(+)]

1

2

High-throughput

0.464

High

1306677

MED15
Mediator of RNA polymerase II transcription subunit 15

1

9

High-throughput

0.464

High

85030

B7Z143
Protein interacting with Ttk69 and Sin3A, isoform D

1

2

High-throughput

0.439

High

118371

M9NDY6
Mushroom-body expressed, isoform I

1

7

High-throughput

0.439

High

119732

M9PBB4
Nimrod C1, isoform B

1

1

High-throughput

0.439

High

1306660

Q8SXN9
polynucleotide adenylyltransferase

1

1

High-throughput

0.439

High

1306663

Q95SJ2
GEO04222p1

1

1

High-throughput

0.439

High

52764

A1Z743
polynucleotide adenylyltransferase

1

1

High-throughput

0.417

High

1019218

P91632
Mushroom-body expressed, isoform A

1

6

High-throughput

0.417

High

1306669

Q9VJU5
Nimrod C1, isoform A

1

1

High-throughput

0.417

High

1306670

Q9VM81
Uncharacterized protein, isoform D

1

1

High-throughput

0.417

High

1306673

Q9VYL7
Protein interacting with Ttk69 and Sin3A, isoform C

1

2

High-throughput

0.417

High

521149

UZIP
Protein unzipped

1

0

High-throughput

0.265

Low

929116

TSG
Protein twisted gastrulation

1

0

High-throughput

0.265

Low

1031727

MS84C
Male-specific sperm protein Mst84Dc

1

0

High-throughput

0.265

Low

1306508

GTR1
Glucose transporter type 1

1

0

High-throughput

0.265

Low

1306664

RAB5
Ras-related protein Rab5

1

0

High-throughput

0.265

Low

1306665

Q9VE75
V-type proton ATPase subunit a

1

0

High-throughput

0.265

Low

1306667

Q9VJ22
GH09876p

1

0

High-throughput

0.265

Low

1306668

Q9VJM1
GEO13348p1

1

0

High-throughput

0.265

Low

1306672

Q9VW93
RE24410p

1

0

High-throughput

0.265

Low

1306674

Q9W1N9
GH08205p

1

0

High-throughput

0.265

Low

1306676

Q9XTL2
Jak pathway signal transduction adaptor molecule

1

0

High-throughput

0.265

Low

84535

B7YZP4
Sulfotransferase 3, isoform B

1

0

High-throughput

0.251

Low

837013

DMYC
Drosomycin

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025