Protein: KPRS
Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate synthase) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)

Gene: KPRS, prs
Organism: Escherichia coli K-12
Interactions: 165
UniProt ID: P0A717

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0002189 - ribose phosphate diphosphokinase complex
GO:0004749 - ribose phosphate diphosphokinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

457527

CH60
Chaperonin GroEL

2

1

High-throughput

0.624

High

442655

DNAJ
Chaperone protein DnaJ

2

5

High-throughput

0.594

High

459686

EFTU1
Elongation factor Tu 1

2

3

High-throughput

0.594

High

459713

CBPA
Curved DNA-binding protein

2

2

High-throughput

0.594

High

459717

RLUB
Ribosomal large subunit pseudouridine synthase B

2

1

High-throughput

0.594

High

459688

LPXB
Lipid-A-disaccharide synthase

2

0

High-throughput

0.585

High

459758

YDJI
Uncharacterized protein YdjI

2

0

High-throughput

0.569

High

459632

RS3
Small ribosomal subunit protein uS3

2

0

High-throughput

0.547

High

459633

RS4
Small ribosomal subunit protein uS4

2

0

High-throughput

0.547

High

459670

RL16
Large ribosomal subunit protein uL16

2

0

High-throughput

0.547

High

459677

NUSA
Transcription termination/antitermination protein NusA

2

0

High-throughput

0.547

High

459731

RL2
Large ribosomal subunit protein uL2

2

0

High-throughput

0.547

High

459751

YDGJ
Uncharacterized oxidoreductase YdgJ

2

1

High-throughput

0.543

High

458279

CLPP
ATP-dependent Clp protease proteolytic subunit

1

2

High-throughput

0.536

High

459636

METK
S-adenosylmethionine synthase

1

1

High-throughput

0.536

High

459643

XERC
Tyrosine recombinase XerC

1

1

High-throughput

0.536

High

459644

XERD
Tyrosine recombinase XerD

1

1

High-throughput

0.536

High

459646

FNR
Fumarate and nitrate reduction regulatory protein

1

1

High-throughput

0.536

High

459655

OMPR
DNA-binding dual transcriptional regulator OmpR

1

3

High-throughput

0.536

High

459659

ACCA
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

1

1

High-throughput

0.536

High

459662

HNS
DNA-binding protein H-NS

1

1

High-throughput

0.536

High

459663

STPA
DNA-binding protein StpA

1

1

High-throughput

0.536

High

459672

DPIA
Transcriptional regulatory protein DpiA

1

3

High-throughput

0.536

High

459708

BASR
Transcriptional regulatory protein BasR

1

3

High-throughput

0.536

High

459709

MODF
ABC transporter ATP-binding protein ModF

1

1

High-throughput

0.536

High

459712

RLUD
Ribosomal large subunit pseudouridine synthase D

1

1

High-throughput

0.536

High

459725

RSTA
Transcriptional regulatory protein RstA

1

3

High-throughput

0.536

High

459748

DDPD
Probable D,D-dipeptide transport ATP-binding protein DdpD

1

1

High-throughput

0.536

High

459756

DDPF
Probable D,D-dipeptide transport ATP-binding protein DdpF

1

1

High-throughput

0.536

High

459741

NPD
NAD-dependent protein deacylase

1

2

High-throughput

0.527

High

459649

ARCA
Aerobic respiration control protein ArcA

1

3

High-throughput

0.515

High

459692

SBCC
Nuclease SbcCD subunit C

1

3

High-throughput

0.515

High

459730

RSMH
Ribosomal RNA small subunit methyltransferase H

1

1

High-throughput

0.515

High

343455

MANA
Mannose-6-phosphate isomerase

1

0

High-throughput

0.513

High

393655

PABB
Aminodeoxychorismate synthase component 1

1

0

High-throughput

0.513

High

428543

THGA
Galactoside O-acetyltransferase

1

0

High-throughput

0.513

High

439446

RECB
RecBCD enzyme subunit RecB

1

0

High-throughput

0.513

High

458844

GREA
Transcription elongation factor GreA

1

0

High-throughput

0.513

High

459618

PROB
Glutamate 5-kinase

1

0

High-throughput

0.513

High

459619

HSLV
ATP-dependent protease subunit HslV

1

0

High-throughput

0.513

High

459637

SUCC
Succinate--CoA ligase [ADP-forming] subunit beta

1

0

High-throughput

0.513

High

459638

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.513

High

459639

TUSA
Sulfur carrier protein TusA

1

0

High-throughput

0.513

High

459640

YEBC
Probable transcriptional regulatory protein YebC

1

0

High-throughput

0.513

High

459641

PSRP
Phosphoenolpyruvate synthase regulatory protein

1

0

High-throughput

0.513

High

459642

YQGF
Putative pre-16S rRNA nuclease

1

0

High-throughput

0.513

High

459645

CSPE
Cold shock-like protein CspE

1

0

High-throughput

0.513

High

459647

MNTR
Transcriptional regulator MntR

1

0

High-throughput

0.513

High

459650

FTSE
Cell division ATP-binding protein FtsE

1

0

High-throughput

0.513

High

459651

LIVG
High-affinity branched-chain amino acid transport ATP-binding protein LivG

1

0

High-throughput

0.513

High

459658

YCII
Protein YciI

1

0

High-throughput

0.513

High

459666

KPYK1
Pyruvate kinase I

1

0

High-throughput

0.513

High

459673

MIAB
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase

1

0

High-throughput

0.513

High

459683

THIO2
Thioredoxin 2

1

0

High-throughput

0.513

High

459689

UNG
Uracil-DNA glycosylase

1

0

High-throughput

0.513

High

459690

BIOA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

1

0

High-throughput

0.513

High

459696

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.513

High

459701

DBPA
ATP-dependent RNA helicase DbpA

1

0

High-throughput

0.513

High

459702

MRAZ
Transcriptional regulator MraZ

1

0

High-throughput

0.513

High

459703

MUKB
Chromosome partition protein MukB

1

0

High-throughput

0.513

High

459704

MUKE
Chromosome partition protein MukE

1

0

High-throughput

0.513

High

459716

RMLD
dTDP-4-dehydrorhamnose reductase

1

0

High-throughput

0.513

High

459719

SPRT
Protein SprT

1

0

High-throughput

0.513

High

459720

YHAK
Pirin-like protein YhaK

1

0

High-throughput

0.513

High

459721

XAPA
Purine nucleoside phosphorylase 2

1

0

High-throughput

0.513

High

459724

HOA
4-hydroxy-2-oxovalerate aldolase

1

0

High-throughput

0.513

High

459726

ABPB
Anti-bacteriophage protein B

1

0

High-throughput

0.513

High

459728

6PGL
6-phosphogluconolactonase

1

0

High-throughput

0.513

High

459729

PRP2
Serine/threonine-protein phosphatase 2

1

0

High-throughput

0.513

High

459737

PROXY
Multifunctional Ser/Thr-tRNA deacylase ProXp-y

1

0

High-throughput

0.513

High

459747

YAHF
Uncharacterized protein YahF

1

0

High-throughput

0.513

High

459631

RS2
Small ribosomal subunit protein uS2

1

1

High-throughput

0.500

High

459687

EFTU2
Elongation factor Tu 2

1

3

High-throughput

0.500

High

459732

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.500

High

459620

PTH
Peptidyl-tRNA hydrolase

1

0

High-throughput

0.493

High

459676

NSRR
HTH-type transcriptional repressor NsrR

1

0

High-throughput

0.493

High

459714

RDGC
Recombination-associated protein RdgC

1

0

High-throughput

0.493

High

393661

FUMC
Fumarate hydratase class II

1

1

High-throughput

0.489

High

459664

MELR
Melibiose operon regulatory protein

1

2

High-throughput

0.489

High

459665

ALLS
HTH-type transcriptional activator AllS

1

6

High-throughput

0.489

High

459711

YFIE
Uncharacterized HTH-type transcriptional regulator YfiE

1

6

High-throughput

0.489

High

459738

AAER
HTH-type transcriptional activator AaeR

1

6

High-throughput

0.489

High

459749

YNEJ
Uncharacterized HTH-type transcriptional regulator YneJ

1

6

High-throughput

0.489

High

459750

PGRR
HTH-type transcriptional regulator PgrR

1

6

High-throughput

0.489

High

459752

WCAA
Putative colanic acid biosynthesis glycosyl transferase WcaA

1

1

High-throughput

0.489

High

459757

YAHB
Uncharacterized HTH-type transcriptional regulator YahB

1

6

High-throughput

0.489

High

459760

YAHD
Putative ankyrin repeat protein YahD

1

3

High-throughput

0.489

High

357007

RS7
Small ribosomal subunit protein uS7

1

0

High-throughput

0.479

High

358352

RL15
Large ribosomal subunit protein uL15

1

0

High-throughput

0.479

High

459634

RS5
Small ribosomal subunit protein uS5

1

0

High-throughput

0.479

High

458166

CH10
Co-chaperonin GroES

1

1

High-throughput

0.479

High

459648

RBSK
Ribokinase

1

1

High-throughput

0.479

High

459660

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

1

4

High-throughput

0.479

High

459695

DNLJ
DNA ligase

1

1

High-throughput

0.479

High

459700

SRMB
ATP-dependent RNA helicase SrmB

1

1

High-throughput

0.479

High

459715

PGM
Phosphoglucomutase

1

1

High-throughput

0.479

High

459763

NAC
Nitrogen assimilation regulatory protein nac

1

6

High-throughput

0.470

High

430823

SYL
Leucine--tRNA ligase

1

0

High-throughput

0.458

High

459617

RPPH
RNA pyrophosphohydrolase

1

0

High-throughput

0.458

High

459657

YBCJ
Putative RNA-binding protein YbcJ

1

0

High-throughput

0.458

High

459739

HDA
DnaA regulatory inactivator Hda

1

0

High-throughput

0.458

High

459038

DNAK
Chaperone protein DnaK

1

3

High-throughput

0.445

High

459653

MREB
Cell shape-determining protein MreB

1

13

High-throughput

0.445

High

459674

GYRB
DNA gyrase subunit B

1

1

High-throughput

0.445

High

459680

RHO
Transcription termination factor Rho

1

2

High-throughput

0.445

High

459616

MURA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase

1

0

High-throughput

0.426

High

459622

RL10
Large ribosomal subunit protein uL10

1

0

High-throughput

0.426

High

459623

RL11
Large ribosomal subunit protein uL11

1

0

High-throughput

0.426

High

459624

RL7
Large ribosomal subunit protein bL12

1

0

High-throughput

0.426

High

459625

RL19
Large ribosomal subunit protein bL19

1

0

High-throughput

0.426

High

459626

RL28
Large ribosomal subunit protein bL28

1

0

High-throughput

0.426

High

459627

RL9
Large ribosomal subunit protein bL9

1

0

High-throughput

0.426

High

459628

RS10
Small ribosomal subunit protein uS10

1

0

High-throughput

0.426

High

459629

RS16
Small ribosomal subunit protein bS16

1

0

High-throughput

0.426

High

459630

RS20
Small ribosomal subunit protein bS20

1

0

High-throughput

0.426

High

459635

RS8
Small ribosomal subunit protein uS8

1

0

High-throughput

0.426

High

459654

RL13
Large ribosomal subunit protein uL13

1

0

High-throughput

0.426

High

459669

RL14
Large ribosomal subunit protein uL14

1

0

High-throughput

0.426

High

459671

RL23
Large ribosomal subunit protein uL23

1

0

High-throughput

0.426

High

459678

NUSG
Transcription termination/antitermination protein NusG

1

0

High-throughput

0.426

High

459681

RL21
Large ribosomal subunit protein bL21

1

0

High-throughput

0.426

High

459684

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

1

0

High-throughput

0.426

High

459733

RL24
Large ribosomal subunit protein uL24

1

0

High-throughput

0.426

High

459734

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.426

High

459735

RL22
Large ribosomal subunit protein uL22

1

0

High-throughput

0.426

High

459736

RL5
Large ribosomal subunit protein uL5

1

0

High-throughput

0.426

High

459722

HOFM
DNA utilization protein HofM

2

0

High-throughput

0.310

High

459740

SXY
Protein Sxy

2

0

High-throughput

0.310

High

341738

CYNS
Cyanate hydratase

1

0

High-throughput

0.279

Low

404393

MCP3
Methyl-accepting chemotaxis protein III

1

0

High-throughput

0.279

Low

459621

RECR
Recombination protein RecR

1

0

High-throughput

0.279

Low

459656

CLSB
Cardiolipin synthase B

1

0

High-throughput

0.279

Low

459661

CYOA
Cytochrome bo(3) ubiquinol oxidase subunit 2

1

0

High-throughput

0.279

Low

459668

YQIB
Uncharacterized protein YqiB

1

0

High-throughput

0.279

Low

459675

HYCH
Formate hydrogenlyase maturation protein HycH

1

0

High-throughput

0.279

Low

459679

RNK
Regulator of nucleoside diphosphate kinase

1

0

High-throughput

0.279

Low

459685

SIRB1
UPF0162 protein YchA

1

0

High-throughput

0.279

Low

459691

BIOC
Malonyl-[acyl-carrier protein] O-methyltransferase

1

0

High-throughput

0.279

Low

459693

MNGR
Mannosyl-D-glycerate transport/metabolism system repressor MngR

1

0

High-throughput

0.279

Low

459697

PHND
Phosphonates-binding periplasmic protein

1

0

High-throughput

0.279

Low

459698

BETI
HTH-type transcriptional regulator BetI

1

0

High-throughput

0.279

Low

459699

NARY
Respiratory nitrate reductase 2 beta chain

1

0

High-throughput

0.279

Low

459705

FLID
Flagellar hook-associated protein 2

1

0

High-throughput

0.279

Low

459706

ROXA
Ribosomal protein uL16 3-hydroxylase

1

0

High-throughput

0.279

Low

459707

MLTG
Endolytic murein transglycosylase

1

0

High-throughput

0.279

Low

459710

YIDL
Uncharacterized HTH-type transcriptional regulator YidL

1

0

High-throughput

0.279

Low

459723

END8
Endonuclease 8

1

0

High-throughput

0.279

Low

459727

YFJR
Uncharacterized HTH-type transcriptional regulator YfjR

1

0

High-throughput

0.279

Low

459742

YDAT
Uncharacterized protein YdaT

1

0

High-throughput

0.279

Low

459743

YDCS
Bifunctional polyhydroxybutyrate synthase / ABC transporter periplasmic binding protein

1

0

High-throughput

0.279

Low

459744

YDIV
Putative anti-FlhC(2)FlhD(4) factor YdiV

1

0

High-throughput

0.279

Low

459745

NIMR
HTH-type transcriptional regulator NimR

1

0

High-throughput

0.279

Low

459746

YPJB
Protein YpjB

1

0

High-throughput

0.279

Low

459753

STFQ
Prophage side tail fiber protein homolog StfQ

1

0

High-throughput

0.279

Low

459754

YFHR
Uncharacterized protein YfhR

1

0

High-throughput

0.279

Low

459755

YDHW
Uncharacterized protein YdhW

1

0

High-throughput

0.279

Low

459759

YDJF
Uncharacterized HTH-type transcriptional regulator YdjF

1

0

High-throughput

0.279

Low

459761

YFES
Uncharacterized protein YfeS

1

0

High-throughput

0.279

Low

459762

LTND
L-threonate dehydrogenase

1

0

High-throughput

0.279

Low

459652

YBAQ
Uncharacterized HTH-type transcriptional regulator YbaQ

1

0

High-throughput

0.269

Low

459718

ERFK
Probable L,D-transpeptidase ErfK/SrfK

1

0

High-throughput

0.269

Low

459764

YAFN
Antitoxin YafN

1

0

High-throughput

0.269

Low

459682

CSDE
Sulfur acceptor protein CsdE

1

0

Small-scale

0.249

Low

459694

RECE
Exodeoxyribonuclease 8

1

0

High-throughput

0.249

Low

459667

YIBA
Protein YibA

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024