Protein: LOC1
60S ribosomal subunit assembly/export protein LOC1 (Localization of ASH1 mRNA protein 1)

Gene: LOC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 155
UniProt ID: P43586

Gene Ontology (top 5):
GO:0000055 - ribosomal large subunit export from nucleus
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003729 - mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

797406

BRX1
Ribosome biogenesis protein BRX1

7

4

Small-scale

0.743

High

797387

HAS1
ATP-dependent RNA helicase HAS1

6

2

High-throughput

0.735

High

731825

EBP2
rRNA-processing protein EBP2

8

0

Small-scale

0.720

High

764196

NOC2
Nucleolar complex protein 2

7

0

Small-scale

0.718

High

778807

NOP2
25S rRNA

5

1

Small-scale

0.712

High

766650

NUG1
Nuclear GTP-binding protein NUG1

5

1

Small-scale

0.711

High

638792

SPB4
ATP-dependent rRNA helicase SPB4

5

2

High-throughput

0.709

High

699695

DRS1
ATP-dependent RNA helicase DRS1

4

1

High-throughput

0.702

High

797421

DBP10
ATP-dependent RNA helicase DBP10

4

1

High-throughput

0.702

High

797424

IF6
Eukaryotic translation initiation factor 6

6

0

Small-scale

0.699

High

797396

FKBP4
FK506-binding protein 4

4

1

High-throughput

0.690

High

634420

SPB1
27S pre-rRNA

5

0

High-throughput

0.688

High

797393

PUF6
Pumilio homology domain family member 6

4

0

Small-scale

0.673

High

757292

FKBP3
Peptidyl-prolyl cis-trans isomerase

3

1

High-throughput

0.670

High

797405

NOP12
Nucleolar protein 12

3

1

High-throughput

0.670

High

732225

RRP14
Ribosomal RNA-processing protein 14

4

0

Small-scale

0.667

High

797372

PESC
Pescadillo homolog

4

0

Small-scale

0.664

High

797385

NOG1
Nucleolar GTP-binding protein 1

4

0

High-throughput

0.660

High

776443

RLP7
Ribosome biogenesis protein RLP7

3

2

High-throughput

0.656

High

733135

DBP7
ATP-dependent RNA helicase DBP7

3

2

High-throughput

0.656

High

797403

NOC3
Nucleolar complex-associated protein 3

3

1

High-throughput

0.650

High

742027

NOP4
Nucleolar protein 4

3

0

High-throughput

0.642

High

797415

NOP53
Ribosome biogenesis protein NOP53

3

0

High-throughput

0.642

High

754874

SSF1
Ribosome biogenesis protein SSF1

3

1

Small-scale

0.640

High

732092

SHE2
SWI5-dependent HO expression protein 2

3

0

Small-scale

0.639

High

744204

MAK5
ATP-dependent RNA helicase MAK5

2

2

High-throughput

0.634

High

797419

MAK21
Ribosome biogenesis protein MAK21

2

2

High-throughput

0.634

High

383211

RL25
Large ribosomal subunit protein uL23

3

0

High-throughput

0.628

High

754136

CIC1
Proteasome-interacting protein CIC1

3

0

Small-scale

0.628

High

755298

RPF1
Ribosome production factor 1

3

0

High-throughput

0.622

High

797394

ERB1
Ribosome biogenesis protein ERB1

3

0

High-throughput

0.622

High

797411

NIP7
60S ribosome subunit biogenesis protein NIP7

3

0

High-throughput

0.622

High

766577

NOP16
Nucleolar protein 16

3

0

High-throughput

0.618

High

768013

NSA2
Ribosome biogenesis protein NSA2

3

0

High-throughput

0.618

High

797379

NOP15
Ribosome biogenesis protein 15

3

0

Small-scale

0.613

High

797364

LOC1
60S ribosomal subunit assembly/export protein LOC1

2

0

High-throughput

0.607

High

797368

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

0

High-throughput

0.607

High

797425

RRP12
Ribosomal RNA-processing protein 12

2

0

High-throughput

0.607

High

733851

RPF2
Ribosome biogenesis protein RPF2

3

0

High-throughput

0.606

High

797395

RRP5
rRNA biogenesis protein RRP5

2

0

High-throughput

0.595

High

797373

DBP6
ATP-dependent RNA helicase DBP6

2

2

High-throughput

0.594

High

535031

RL3
Large ribosomal subunit protein uL3

2

0

High-throughput

0.585

High

645061

RL16A
Large ribosomal subunit protein uL13A

2

0

High-throughput

0.585

High

696358

PP12
Serine/threonine-protein phosphatase PP1-2

2

0

High-throughput

0.585

High

703068

MRT4
Ribosome assembly factor MRT4

2

0

High-throughput

0.585

High

797369

NSA1
Ribosome biogenesis protein NSA1

2

0

High-throughput

0.585

High

797413

YTM1
Ribosome biogenesis protein YTM1

2

0

High-throughput

0.585

High

797400

NOC4
Nucleolar complex protein 4

2

2

Small-scale

0.584

High

648388

NSR1
Nuclear localization sequence-binding protein

2

0

High-throughput

0.569

High

797370

CGR1
rRNA-processing protein CGR1

2

0

High-throughput

0.569

High

797408

TMA16
Translation machinery-associated protein 16

2

0

High-throughput

0.569

High

775193

ULP2
Ubiquitin-like-specific protease 2

2

0

High-throughput

0.561

High

594052

MAK11
Protein MAK11

2

0

Small-scale

0.559

High

715457

RRP1
Ribosomal RNA-processing protein 1

2

0

Small-scale

0.559

High

792472

UTP10
U3 small nucleolar RNA-associated protein 10

2

0

High-throughput

0.559

High

797389

RRP17
Ribosomal RNA-processing protein 17

2

0

High-throughput

0.559

High

797399

RRP15
Ribosomal RNA-processing protein 15

2

0

Small-scale

0.559

High

797404

RLP24
Ribosome biogenesis protein RLP24

2

0

Small-scale

0.559

High

404622

RL7A
Large ribosomal subunit protein uL30A

1

2

High-throughput

0.536

High

797367

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.536

High

797420

RL7B
Large ribosomal subunit protein uL30B

1

2

High-throughput

0.536

High

597854

PWP1
Periodic tryptophan protein 1

1

0

High-throughput

0.518

High

655857

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.518

High

797376

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

High-throughput

0.518

High

419351

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.513

High

534786

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.513

High

640985

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

664488

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

676150

XPO1
Exportin-1

1

0

High-throughput

0.513

High

797375

ELOA1
Elongin-A

1

0

High-throughput

0.513

High

797377

IPI3
Pre-rRNA-processing protein IPI3

1

0

High-throughput

0.513

High

797390

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.513

High

615161

BUR1
Serine/threonine-protein kinase BUR1

1

0

High-throughput

0.493

High

797414

THP3
Protein THP3

1

0

High-throughput

0.493

High

667211

RL8B
Large ribosomal subunit protein eL8B

1

1

High-throughput

0.489

High

355526

H2B1
Histone H2B.1

1

1

High-throughput

0.479

High

355922

H2B2
Histone H2B.2

1

1

High-throughput

0.479

High

481174

RL1A
Large ribosomal subunit protein uL1A

1

1

High-throughput

0.479

High

662558

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

663885

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.479

High

797374

NOG2
Nucleolar GTP-binding protein 2

1

1

Small-scale

0.479

High

797381

RCM1
25S rRNA

1

1

High-throughput

0.479

High

797398

DBP9
ATP-dependent RNA helicase DBP9

1

2

High-throughput

0.479

High

797417

SSF2
Ribosome biogenesis protein SSF2

1

1

High-throughput

0.479

High

797422

NOP56
Nucleolar protein 56

1

1

Small-scale

0.479

High

797423

NOP58
Nucleolar protein 58

1

1

High-throughput

0.479

High

356546

H4
Histone H4

1

0

High-throughput

0.458

High

392477

H2A2
Histone H2A.2

1

0

High-throughput

0.458

High

405687

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

407131

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

408395

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

413577

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

481039

RL23B
Large ribosomal subunit protein uL14B

1

0

High-throughput

0.458

High

482315

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

501227

MAK16
Protein MAK16

1

0

High-throughput

0.458

High

524356

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

630214

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

631945

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

634662

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

645513

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

650318

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.458

High

687961

IMB3
Importin subunit beta-3

1

0

Small-scale

0.458

High

688297

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

700480

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

729972

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

731588

EAP1
Protein EAP1

1

0

High-throughput

0.458

High

742856

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.458

High

746247

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

748639

ENP1
Essential nuclear protein 1

1

0

High-throughput

0.458

High

752518

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

761969

DHH1
ATP-dependent RNA helicase DHH1

1

0

Small-scale

0.458

High

764976

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

Small-scale

0.458

High

775752

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

797365

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

797366

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

797371

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.458

High

797378

NOP13
Nucleolar protein 13

1

0

High-throughput

0.458

High

797380

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

797382

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

797384

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

797386

ISU1
Iron sulfur cluster assembly protein 1, mitochondrial

1

0

Small-scale

0.458

High

797388

ARX1
Probable metalloprotease ARX1

1

0

Small-scale

0.458

High

797391

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

797392

RRB1
Ribosome assembly protein RRB1

1

0

High-throughput

0.458

High

797397

JIP5
WD repeat-containing protein JIP5

1

0

High-throughput

0.458

High

797401

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

797402

HBT1
Protein HBT1

1

0

High-throughput

0.458

High

797407

SGO1
Shugoshin

1

0

High-throughput

0.458

High

797409

HRK1
Serine/threonine-protein kinase HRK1

1

0

High-throughput

0.458

High

797410

RRS1
Regulator of ribosome biosynthesis

1

0

High-throughput

0.458

High

797412

BMS1
Ribosome biogenesis protein BMS1

1

0

High-throughput

0.458

High

797416

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

797418

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

498976

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.445

High

564317

RL8A
Large ribosomal subunit protein eL8A

1

1

Small-scale

0.437

High

424575

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

604574

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.426

High

753675

RL14B
Large ribosomal subunit protein eL14B

1

0

High-throughput

0.426

High

797383

SEN1
Helicase SEN1

1

0

Small-scale

0.426

High

479129

RL43B
Large ribosomal subunit protein eL43B

2

0

Small-scale

0.328

High

472255

RL31A
Large ribosomal subunit protein eL31A

2

0

High-throughput

0.305

High

404863

RL9A
Large ribosomal subunit protein uL6A

1

0

High-throughput

0.279

Low

770404

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.279

Low

426012

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

471120

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

478917

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

480737

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

586166

PMA2
Plasma membrane ATPase 2

1

0

High-throughput

0.249

Low

706338

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

747372

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

752316

HXT5
Probable glucose transporter HXT5

1

0

High-throughput

0.249

Low

762317

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

773937

MLP2
Protein MLP2

1

0

High-throughput

0.249

Low

797426

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024