Protein: DOT1
Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (Disrupter of telomere silencing protein 1) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)

Gene: DOT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 31
UniProt ID: Q04089

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000725 - recombinational repair
GO:0000781 - chromosome, telomeric region
GO:0000786 - nucleosome
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

902044

H3
Histone H3

9

4

Small-scale

0.973

High

356695

H4
Histone H4

4

0

Small-scale

0.844

High

355623

H2B1
Histone H2B.1

2

3

Small-scale

0.755

High

477435

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

Small-scale

0.687

High

356000

H2B2
Histone H2B.2

1

3

Small-scale

0.647

High

392193

H2A1
Histone H2A.1

1

2

Small-scale

0.647

High

392557

H2A2
Histone H2A.2

1

2

Small-scale

0.647

High

978548

DOT1
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.575

High

732686

SWD2
COMPASS component SWD2

1

6

Small-scale

0.515

High

978553

YRA1
RNA annealing protein YRA1

1

4

High-throughput

0.515

High

746340

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

1

High-throughput

0.508

High

562759

FUS3
Mitogen-activated protein kinase FUS3

1

3

High-throughput

0.501

High

691116

HOG1
Mitogen-activated protein kinase HOG1

1

2

Small-scale

0.501

High

614796

KC11
Casein kinase I homolog 1

1

0

High-throughput

0.480

High

978549

CORO
Coronin-like protein

1

3

High-throughput

0.470

High

978550

IMH1
Golgin IMH1

1

3

High-throughput

0.470

High

978551

RRS1
Regulator of ribosome biosynthesis

1

1

High-throughput

0.470

High

663217

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

978552

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

492325

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

494872

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

512598

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

695449

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

757332

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.426

High

544356

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.407

High

766189

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.407

High

774525

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

0

High-throughput

0.269

Low

842748

INP52
Polyphosphatidylinositol phosphatase INP52

1

0

High-throughput

0.269

Low

810136

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

978554

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024