Protein: GCN2
eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (General control non-derepressible protein 2) (Serine/threonine-protein kinase GCN2)

Gene: GCN2
Organism: Saccharomyces cerevisiae S288C
Interactions: 90
UniProt ID: P15442

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0000077 - DNA damage checkpoint signaling
GO:0003725 - double-stranded RNA binding
GO:0004672 - protein kinase activity
GO:0004694 - eukaryotic translation initiation factor 2alpha kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

548499

GCN2
eIF-2-alpha kinase GCN2

6

18

Small-scale

0.957

High

548517

HRR25
Casein kinase I homolog HRR25

3

15

Small-scale

0.871

High

365717

HSP82
ATP-dependent molecular chaperone HSP82

3

20

Small-scale

0.856

High

548509

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

2

10

Small-scale

0.778

High

548530

KOG1
Target of rapamycin complex 1 subunit KOG1

1

4

Small-scale

0.747

High

548554

PKH1
Serine/threonine-protein kinase PKH1

1

18

Small-scale

0.747

High

548524

GCN1
eIF-2-alpha kinase activator GCN1

5

7

Small-scale

0.720

High

526181

KIN2
Serine/threonine-protein kinase KIN2

1

15

High-throughput

0.691

High

548511

NPR1
Nitrogen permease reactivator protein

1

20

High-throughput

0.691

High

548545

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

4

High-throughput

0.691

High

367689

EF1A
Elongation factor 1-alpha

4

2

Small-scale

0.689

High

548526

HSL1
Probable serine/threonine-protein kinase HSL1

1

17

High-throughput

0.665

High

548566

YRA1
RNA annealing protein YRA1

1

4

High-throughput

0.665

High

515160

SCH9
Serine/threonine-protein kinase SCH9

1

18

Small-scale

0.647

High

548555

SKY1
Serine/threonine-protein kinase SKY1

1

17

High-throughput

0.647

High

548537

GCN20
Protein GCN20

2

1

Small-scale

0.629

High

548506

PRP6
Pre-mRNA-splicing factor 6

2

4

High-throughput

0.621

High

548507

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

2

3

High-throughput

0.621

High

548528

SN114
Pre-mRNA-splicing factor SNU114

2

5

High-throughput

0.621

High

548561

RGC1
Regulator of the glycerol channel 1

2

2

High-throughput

0.619

High

419788

SNF1
Carbon catabolite-derepressing protein kinase

1

15

Small-scale

0.618

High

548547

UBC9
SUMO-conjugating enzyme UBC9

1

5

High-throughput

0.618

High

548550

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.618

High

548548

EIF2A
Eukaryotic translation initiation factor 2A

2

5

Small-scale

0.602

High

548519

AAR2
A1 cistron-splicing factor AAR2

2

0

High-throughput

0.595

High

548546

PRP31
Pre-mRNA-processing factor 31

2

0

High-throughput

0.595

High

548568

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

2

0

High-throughput

0.595

High

548560

UTP21
U3 small nucleolar RNA-associated protein 21

2

1

High-throughput

0.588

High

493105

HSP72
Heat shock protein SSA2

2

15

High-throughput

0.552

High

548518

XPO1
Exportin-1

1

4

High-throughput

0.536

High

548522

BRR2
Pre-mRNA-splicing helicase BRR2

1

3

High-throughput

0.536

High

548523

PRP8
Pre-mRNA-splicing factor 8

1

2

High-throughput

0.536

High

548543

YMR1
Phosphoinositide 3-phosphatase

1

3

High-throughput

0.536

High

514136

NHP6A
Non-histone chromosomal protein 6A

1

7

High-throughput

0.515

High

540204

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

1

9

High-throughput

0.515

High

548515

SPT5
Transcription elongation factor SPT5

1

2

High-throughput

0.515

High

548532

STM1
Suppressor protein STM1

1

1

High-throughput

0.515

High

548549

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.515

High

548556

HMO1
High mobility group protein 1

1

5

High-throughput

0.515

High

541604

SEC63
Protein translocation protein SEC63

1

8

High-throughput

0.514

High

548536

RRG9
Required for respiratory growth protein 9, mitochondrial

1

0

High-throughput

0.513

High

425450

TFS2
Transcription elongation factor S-II

1

1

High-throughput

0.501

High

470828

RS22A
Small ribosomal subunit protein uS8A

1

2

Small-scale

0.501

High

548504

RDS2
Regulator of drug sensitivity 2

1

2

High-throughput

0.501

High

548508

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.501

High

548525

YBF5
Deoxyribonuclease Tat-D

1

1

High-throughput

0.501

High

548569

RS22B
Small ribosomal subunit protein uS8B

1

2

Small-scale

0.501

High

548501

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

2

High-throughput

0.500

High

548513

CDC48
Cell division control protein 48

1

3

High-throughput

0.500

High

548558

SAS4
Something about silencing protein 4

1

0

High-throughput

0.493

High

548559

GFD1
mRNA transport factor GFD1

1

0

High-throughput

0.493

High

548539

NMD5
Nonsense-mediated mRNA decay protein 5

1

5

Small-scale

0.481

High

387873

RL39
Large ribosomal subunit protein eL39

1

0

Small-scale

0.480

High

447153

IF2B
Eukaryotic translation initiation factor 2 subunit beta

1

0

Small-scale

0.480

High

548552

2ABA
Protein phosphatase PP2A regulatory subunit B

1

0

High-throughput

0.480

High

548553

NAA35
N-alpha-acetyltransferase 35, NatC auxiliary subunit

1

0

High-throughput

0.480

High

548564

NOB1
20S-pre-rRNA D-site endonuclease NOB1

1

0

High-throughput

0.480

High

548505

PMA2
Plasma membrane ATPase 2

1

3

High-throughput

0.479

High

548510

XRN1
5'-3' exoribonuclease 1

1

1

Small-scale

0.479

High

548514

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

548516

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

548527

TOR1
Serine/threonine-protein kinase TOR1

1

10

Small-scale

0.479

High

548544

IML1
Vacuolar membrane-associated protein IML1

1

2

High-throughput

0.479

High

548557

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

548565

RRP6
Exosome complex exonuclease RRP6

1

2

High-throughput

0.479

High

548503

CLC1
Clathrin light chain

1

1

High-throughput

0.470

High

548551

SLM2
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2

1

2

High-throughput

0.470

High

368712

GCN4
General control transcription factor GCN4

1

0

Small-scale

0.460

High

548542

DPOD3
DNA polymerase delta subunit 3

1

0

Small-scale

0.460

High

548502

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

548562

HBT1
Protein HBT1

1

0

High-throughput

0.458

High

548567

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.458

High

548538

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

9

High-throughput

0.457

High

548529

HMT1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.457

High

424322

PYR1
Multifunctional protein URA2

1

5

High-throughput

0.445

High

449888

HSP73
Heat shock protein SSA3

1

15

High-throughput

0.445

High

490220

HSP71
Heat shock protein SSA1

1

15

High-throughput

0.445

High

510137

SSB1
Ribosome-associated molecular chaperone SSB1

1

15

High-throughput

0.445

High

548500

VATB
V-type proton ATPase subunit B

1

7

High-throughput

0.445

High

548520

HSP7F
Heat shock protein homolog SSE1

1

19

High-throughput

0.445

High

548521

HSP79
Heat shock protein homolog SSE2

1

19

High-throughput

0.445

High

548533

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.445

High

548534

HSP7E
Heat shock protein SSC3, mitochondrial

1

16

High-throughput

0.445

High

548535

SSB2
Ribosome-associated molecular chaperone SSB2

1

15

High-throughput

0.445

High

548540

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.445

High

548541

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.445

High

548531

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

1

Small-scale

0.437

High

548512

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

548563

SPO75
Sporulation-specific protein 75

1

0

High-throughput

0.269

Low


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Last updated: 15 Jul 2024