Protein: H2AZ
Histone H2A.Z

Gene: H2AZ, HTZ1
Organism: Saccharomyces cerevisiae S288C
Interactions: 224
UniProt ID: Q12692

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000786 - nucleosome
GO:0000791 - euchromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

670368

NAP1
Nucleosome assembly protein

15

19

Small-scale

0.981

High

381330

H2B1
Histone H2B.1

12

20

Small-scale

0.977

High

1051144

SWR1
Helicase SWR1

11

20

Small-scale

0.975

High

963819

H3
Histone H3

11

20

Small-scale

0.972

High

1042552

VPS72
Vacuolar protein sorting-associated protein 72

9

7

Small-scale

0.972

High

382435

H4
Histone H4

10

17

Small-scale

0.969

High

381682

H2B2
Histone H2B.2

10

20

Small-scale

0.967

High

419536

H2A1
Histone H2A.1

6

19

Small-scale

0.950

High

419924

H2A2
Histone H2A.2

7

19

Small-scale

0.946

High

916905

IMB5
Importin subunit beta-5

6

10

Small-scale

0.938

High

817201

CHZ1
Histone H2A.Z-specific chaperone CHZ1

9

0

Small-scale

0.910

High

921183

H1
Histone H1

4

1

Small-scale

0.885

High

1085042

H2AZ
Histone H2A.Z

3

19

Small-scale

0.871

High

739837

SPT16
FACT complex subunit SPT16

3

8

Small-scale

0.853

High

794247

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

3

20

High-throughput

0.817

High

925469

HDA1
Histone deacetylase HDA1

2

14

Small-scale

0.806

High

1064662

ESA1
Histone acetyltransferase ESA1

2

20

Small-scale

0.755

High

757783

SAS3
Histone acetyltransferase SAS3

2

18

Small-scale

0.754

High

792329

GBLP
Small ribosomal subunit protein RACK1

2

7

High-throughput

0.754

High

1010227

ARP4
Actin-related protein 4

8

17

Small-scale

0.746

High

1044527

RUVB1
RuvB-like protein 1

8

13

Small-scale

0.746

High

725989

SWC3
SWR1-complex protein 3

7

1

Small-scale

0.742

High

918188

SWC4
SWR1-complex protein 4

7

3

Small-scale

0.742

High

1084961

RUVB2
RuvB-like protein 2

7

13

Small-scale

0.742

High

736763

ASF1
Histone chaperone ASF1

2

1

Small-scale

0.737

High

743158

STH1
Nuclear protein STH1/NPS1

2

20

High-throughput

0.737

High

744367

CHD1
Chromo domain-containing protein 1

2

20

High-throughput

0.737

High

817997

IMB4
Importin subunit beta-4

2

9

Small-scale

0.737

High

1040037

HOS3
Histone deacetylase HOS3

2

18

High-throughput

0.737

High

1046972

POB3
FACT complex subunit POB3

2

11

High-throughput

0.737

High

777148

BDF1
Bromodomain-containing factor 1

6

20

Small-scale

0.727

High

924916

AF9
Protein AF-9 homolog

5

7

Small-scale

0.714

High

948707

ACT
Actin

5

8

Small-scale

0.712

High

1085006

ARP6
Actin-like protein ARP6

5

11

Small-scale

0.706

High

1042805

VPS71
Vacuolar protein sorting-associated protein 71

6

0

Small-scale

0.699

High

724895

RAD16
DNA repair protein RAD16

1

19

High-throughput

0.691

High

798134

SWC5
SWR1-complex protein 5

4

7

Small-scale

0.691

High

1056586

SWC7
SWR1-complex protein 7

3

1

Small-scale

0.656

High

739930

RPD3
Histone deacetylase RPD3

1

15

Small-scale

0.647

High

1042417

GCN5
Histone acetyltransferase GCN5

3

20

Small-scale

0.641

High

823069

ATAD2
ATPase histone chaperone YTA7

3

6

High-throughput

0.633

High

919706

RT102
Regulator of Ty1 transposition protein 102

3

2

Small-scale

0.633

High

1084230

IOC2
ISWI one complex protein 2

3

1

High-throughput

0.633

High

781293

BYE1
Transcription factor BYE1

1

2

High-throughput

0.618

High

818600

NCB1
Negative cofactor 2 complex subunit alpha

1

1

Small-scale

0.618

High

932266

ORC1
Origin recognition complex subunit 1

1

10

High-throughput

0.618

High

1047311

ERB1
Ribosome biogenesis protein ERB1

1

6

High-throughput

0.618

High

1054046

SFH1
Chromatin structure-remodeling complex subunit SFH1

1

5

High-throughput

0.618

High

1055693

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

20

High-throughput

0.618

High

1085011

CMR1
DNA damage-binding protein CMR1

1

13

High-throughput

0.618

High

805243

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

2

8

Small-scale

0.601

High

849817

EPL1
Enhancer of polycomb-like protein 1

2

4

Small-scale

0.601

High

1055173

CORO
Coronin-like protein

1

7

High-throughput

0.595

High

449037

TOP2
DNA topoisomerase 2

2

8

High-throughput

0.584

High

580313

HSC82
ATP-dependent molecular chaperone HSC82

3

3

High-throughput

0.578

High

448249

HAP2
Transcriptional activator HAP2

1

1

High-throughput

0.575

High

713066

MCM2
DNA replication licensing factor MCM2

1

20

High-throughput

0.575

High

734505

BTAF1
TATA-binding protein-associated factor MOT1

1

20

High-throughput

0.575

High

781824

SET3
SET domain-containing protein 3

1

11

High-throughput

0.575

High

794025

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

7

High-throughput

0.575

High

820455

RT106
Histone chaperone RTT106

1

1

High-throughput

0.575

High

863973

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

12

High-throughput

0.575

High

916627

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

2

High-throughput

0.575

High

1046014

IOC4
ISWI one complex protein 4

1

1

High-throughput

0.575

High

1048425

RCO1
Transcriptional regulatory protein RCO1

1

20

High-throughput

0.575

High

1055396

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

20

High-throughput

0.575

High

1064908

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

20

High-throughput

0.575

High

1084909

EAF3
Chromatin modification-related protein EAF3

1

7

High-throughput

0.575

High

1084993

CAF1A
Chromatin assembly factor 1 subunit A

1

3

High-throughput

0.575

High

561555

TBP
TATA-box-binding protein

2

2

Small-scale

0.571

High

678358

RSC6
Chromatin structure-remodeling complex protein RSC6

2

3

High-throughput

0.571

High

745636

RSC7
Chromatin structure-remodeling complex subunit RSC7

2

1

High-throughput

0.571

High

764047

SPT10
Protein SPT10

2

1

High-throughput

0.571

High

807185

FKBP3
Peptidyl-prolyl cis-trans isomerase

2

7

High-throughput

0.571

High

850609

RSC8
Chromatin structure-remodeling complex protein RSC8

2

11

High-throughput

0.571

High

1035361

RSC4
Chromatin structure-remodeling complex subunit RSC4

2

20

High-throughput

0.571

High

1041016

RSC9
Chromatin structure-remodeling complex subunit RSC9

2

2

High-throughput

0.571

High

1054274

FKBP4
FK506-binding protein 4

2

7

High-throughput

0.571

High

1059311

BDF2
Bromodomain-containing factor 2

2

20

High-throughput

0.571

High

1084889

ARP7
Actin-related protein 7

2

15

High-throughput

0.571

High

1084153

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

2

0

Small-scale

0.547

High

547841

NHP6A
Non-histone chromosomal protein 6A

1

20

High-throughput

0.541

High

546900

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.536

High

752932

HSP78
Heat shock protein 78, mitochondrial

2

4

High-throughput

0.521

High

864352

NET1
Nucleolar protein NET1

2

1

High-throughput

0.521

High

817662

UTP7
U3 small nucleolar RNA-associated protein 7

1

6

High-throughput

0.514

High

440875

KIN28
Serine/threonine-protein kinase KIN28

1

6

High-throughput

0.501

High

646001

DBF2
Cell cycle protein kinase DBF2

1

12

Small-scale

0.501

High

1044572

CTK1
CTD kinase subunit alpha

1

10

High-throughput

0.501

High

781072

T2EA
Transcription initiation factor IIE subunit alpha

1

0

High-throughput

0.493

High

782507

RPF2
Ribosome biogenesis protein RPF2

1

2

High-throughput

0.489

High

917520

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

4

High-throughput

0.489

High

1039699

ELP3
Elongator complex protein 3

1

0

Small-scale

0.480

High

1048265

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.480

High

393590

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.479

High

402160

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

6

High-throughput

0.479

High

435460

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.479

High

448343

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

2

High-throughput

0.479

High

628101

FKBP
FK506-binding protein 1

1

7

Small-scale

0.479

High

641454

RCC1
Guanine nucleotide exchange factor SRM1

1

5

Small-scale

0.479

High

647870

RFA1
Replication factor A protein 1

1

5

Small-scale

0.479

High

653811

APN1
Apurinic-apyrimidinic endonuclease 1

1

1

High-throughput

0.479

High

708643

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

713598

RIF1
Telomere length regulator protein RIF1

1

2

Small-scale

0.479

High

727437

HS104
Heat shock protein 104

1

4

High-throughput

0.479

High

764182

SPT21
Protein SPT21

1

1

High-throughput

0.479

High

776684

DEF1
RNA polymerase II degradation factor 1

1

3

Small-scale

0.479

High

794297

CHK1
Serine/threonine-protein kinase CHK1

1

2

High-throughput

0.479

High

796045

LDB7
Chromatin structure-remodeling complex protein RSC14

1

1

High-throughput

0.479

High

808943

UME6
Transcriptional regulatory protein UME6

1

1

High-throughput

0.479

High

816573

SNU13
13 kDa ribonucleoprotein-associated protein

1

4

High-throughput

0.479

High

824822

MLP2
Protein MLP2

1

15

High-throughput

0.479

High

826124

ULP2
Ubiquitin-like-specific protease 2

1

3

High-throughput

0.479

High

826971

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

925172

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.479

High

1036970

ABF2
ARS-binding factor 2, mitochondrial

1

20

High-throughput

0.479

High

1044614

HMO1
High mobility group protein 1

1

20

High-throughput

0.479

High

1050256

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

1

Small-scale

0.479

High

1054885

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

1064310

SGO1
Shugoshin

1

1

High-throughput

0.479

High

1084513

PSH1
RING finger protein PSH1

1

6

Small-scale

0.479

High

1085043

HTL1
High temperature lethal protein 1

1

1

Small-scale

0.479

High

740772

SRP40
Suppressor protein SRP40

1

2

High-throughput

0.470

High

858157

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.470

High

1084734

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.460

High

745927

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

809449

STM1
Suppressor protein STM1

1

0

Small-scale

0.458

High

1046567

YD514
Uncharacterized protein YDR514C

1

0

Small-scale

0.458

High

1046900

DPB4
DNA polymerase epsilon subunit D

1

0

Small-scale

0.458

High

1054927

VPS74
Vacuolar protein sorting-associated protein 74

1

0

High-throughput

0.458

High

1064499

IES4
Ino eighty subunit 4

1

0

Small-scale

0.458

High

1084264

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.458

High

489021

SWI6
Regulatory protein SWI6

1

7

High-throughput

0.445

High

525682

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

528129

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

548810

MCM1
Pheromone receptor transcription factor

1

2

High-throughput

0.445

High

576029

CYPH
Peptidyl-prolyl cis-trans isomerase

1

1

High-throughput

0.445

High

645656

AFT1
Iron-regulated transcriptional activator AFT1

1

1

High-throughput

0.445

High

664482

MCM3
DNA replication licensing factor MCM3

1

20

High-throughput

0.445

High

671576

SWI4
Regulatory protein SWI4

1

7

High-throughput

0.445

High

676507

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

713320

MCM5
Minichromosome maintenance protein 5

1

20

High-throughput

0.445

High

737435

FKBP2
Peptidyl-prolyl cis-trans isomerase FPR2

1

5

High-throughput

0.445

High

742772

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.445

High

757574

YOX1
Homeobox protein YOX1

1

3

High-throughput

0.445

High

763407

TAF14
Transcription initiation factor TFIID subunit 14

1

7

High-throughput

0.445

High

804016

RSC30
Chromatin structure-remodeling complex protein RSC30

1

4

High-throughput

0.445

High

811445

CAJ1
Protein CAJ1

1

7

High-throughput

0.445

High

816631

EAF5
Chromatin modification-related protein EAF5

1

2

Small-scale

0.445

High

820227

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

850393

IOC3
ISWI one complex protein 3

1

2

High-throughput

0.445

High

858490

TAF1
Transcription initiation factor TFIID subunit 1

1

1

High-throughput

0.445

High

864391

SMC3
Structural maintenance of chromosomes protein 3

1

5

High-throughput

0.445

High

893384

TAF4
Transcription initiation factor TFIID subunit 4

1

3

High-throughput

0.445

High

917084

MCM6
DNA replication licensing factor MCM6

1

20

High-throughput

0.445

High

917411

ITC1
Imitation switch two complex protein 1

1

5

High-throughput

0.445

High

932322

ORC3
Origin recognition complex subunit 3

1

1

High-throughput

0.445

High

1026876

CDC14
Tyrosine-protein phosphatase CDC14

1

2

High-throughput

0.445

High

1036953

TBF1
Protein TBF1

1

1

High-throughput

0.445

High

1043455

YE11B
Transposon Ty1-ER1 Gag-Pol polyprotein

1

1

High-throughput

0.445

High

1043998

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

1

High-throughput

0.445

High

1044178

GIS1
Transcriptional activator/repressor GIS1

1

3

High-throughput

0.445

High

1050608

ARP9
Actin-like protein ARP9

1

12

High-throughput

0.445

High

1056362

RSC3
Chromatin structure-remodeling complex protein RSC3

1

4

High-throughput

0.445

High

1061392

RSC58
Chromatin structure-remodeling complex protein RSC58

1

1

High-throughput

0.445

High

1084856

ARP8
Actin-like protein ARP8

1

12

High-throughput

0.445

High

150029

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.437

High

367281

ATP6
ATP synthase subunit a

1

1

Small-scale

0.437

High

383967

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.437

High

753669

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

410416

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

433920

RL26A
Large ribosomal subunit protein uL24A

1

5

High-throughput

0.437

High

436248

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

442191

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

455336

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.437

High

503318

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

504492

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

512732

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.437

High

513299

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

674914

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.437

High

677640

KRR1
KRR1 small subunit processome component

1

5

High-throughput

0.437

High

682438

SPB4
ATP-dependent rRNA helicase SPB4

1

8

High-throughput

0.437

High

689740

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

745115

AFG2
ATPase family gene 2 protein

1

3

Small-scale

0.437

High

747661

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

778609

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.437

High

786004

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.437

High

802464

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

803976

CIC1
Proteasome-interacting protein CIC1

1

2

High-throughput

0.437

High

812802

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

815292

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.437

High

825791

MAM33
Mitochondrial acidic protein MAM33

1

1

High-throughput

0.437

High

827653

RLP7
Ribosome biogenesis protein RLP7

1

2

High-throughput

0.437

High

923902

GIS2
Zinc finger protein GIS2

1

2

High-throughput

0.437

High

925411

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

1033650

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.437

High

1050007

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

2

High-throughput

0.437

High

1062801

BRX1
Ribosome biogenesis protein BRX1

1

7

High-throughput

0.437

High

1064844

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

645285

GAS1
1,3-beta-glucanosyltransferase GAS1

1

0

High-throughput

0.426

High

863194

YPP1
Cargo-transport protein YPP1

1

0

High-throughput

0.426

High

932287

MOT3
Transcriptional activator/repressor MOT3

1

0

High-throughput

0.426

High

1057436

RAF
Trans-acting factor D

1

0

High-throughput

0.426

High

1061507

CDC45
Cell division control protein 45

1

0

High-throughput

0.426

High

661705

MPCP
Mitochondrial phosphate carrier protein

1

4

High-throughput

0.407

High

755202

GCN1
eIF-2-alpha kinase activator GCN1

1

8

High-throughput

0.407

High

826518

DJP1
DnaJ-like protein 1

1

7

High-throughput

0.407

High

851036

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.407

High

858407

STU2
Protein STU2

1

3

High-throughput

0.407

High

871458

HLJ1
Protein HLJ1

1

3

High-throughput

0.407

High

1056468

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

1

High-throughput

0.407

High

864869

MPS3
Spindle pole body assembly component MPS3

6

0

Small-scale

0.382

High

932645

TMEDA
Endoplasmic reticulum vesicle protein 25

1

0

High-throughput

0.269

Low

514907

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

705239

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

918506

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

1062779

YO075
Uncharacterized ABC transporter ATP-binding protein/permease YOL075C

1

0

Small-scale

0.249

Low

439178

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.232

Low

452543

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.232

Low

618637

FAS2
Fatty acid synthase subunit alpha

1

0

High-throughput

0.232

Low

790239

GLYC
Serine hydroxymethyltransferase, cytosolic

1

0

High-throughput

0.232

Low

863807

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

868467

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025