Protein: EEA1
Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2)

Gene: EEA1
Organism: Homo sapiens
Interactions: 140
UniProt ID: Q15075

Gene Ontology (top 5):
GO:0005516 - calmodulin binding
GO:0005545 - 1-phosphatidylinositol binding
GO:0005769 - early endosome
GO:0005829 - cytosol
GO:0005969 - serine-pyruvate aminotransferase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1067423

EEA1
Early endosome antigen 1

4

17

Small-scale

0.885

High

592265

RAB5A
Ras-related protein Rab-5A

12

9

Small-scale

0.756

High

1067441

ZFY16
Zinc finger FYVE domain-containing protein 16

2

14

Small-scale

0.754

High

844532

RAB5C
Ras-related protein Rab-5C

4

8

Small-scale

0.683

High

241169

TOM1
Target of Myb1 membrane trafficking protein

1

3

Small-scale

0.618

High

313538

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

15

High-throughput

0.618

High

1067461

RUFY1
RUN and FYVE domain-containing protein 1

1

14

High-throughput

0.618

High

1067481

ANFY1
Rabankyrin-5

1

9

High-throughput

0.618

High

1044476

RAB31
Ras-related protein Rab-31

2

10

Small-scale

0.602

High

397031

PAI2
Plasminogen activator inhibitor 2

2

1

High-throughput

0.574

High

876599

AF17
Protein AF-17

2

5

High-throughput

0.574

High

1067464

NUP58
Nucleoporin p58/p45

2

3

High-throughput

0.574

High

164899

SC16A
Protein transport protein Sec16A

2

8

High-throughput

0.571

High

603171

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

2

2

High-throughput

0.571

High

717846

BMI1
Polycomb complex protein BMI-1

2

8

High-throughput

0.571

High

878183

SEC13
Protein SEC13 homolog

2

14

High-throughput

0.571

High

519385

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

2

3

High-throughput

0.558

High

1067451

RUFY2
RUN and FYVE domain-containing protein 2

1

17

High-throughput

0.553

High

895354

RAB5B
Ras-related protein Rab-5B

1

9

Small-scale

0.552

High

1067485

RB22A
Ras-related protein Rab-22A

1

10

Small-scale

0.552

High

267286

HSBP1
Heat shock factor-binding protein 1

1

1

High-throughput

0.536

High

270636

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

4

High-throughput

0.536

High

280880

KRT37
Keratin, type I cuticular Ha7

1

18

High-throughput

0.536

High

280983

KRT38
Keratin, type I cuticular Ha8

1

18

High-throughput

0.536

High

383815

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

4

Small-scale

0.536

High

451442

CLCA
Clathrin light chain A

1

3

High-throughput

0.536

High

455468

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.536

High

472704

FBSP1
F-box/SPRY domain-containing protein 1

1

15

High-throughput

0.536

High

528099

BMP1
Bone morphogenetic protein 1

1

2

High-throughput

0.536

High

796747

RANG
Ran-specific GTPase-activating protein

1

7

High-throughput

0.536

High

1067448

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

1

High-throughput

0.536

High

1067459

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

14

High-throughput

0.536

High

1067463

AIF1L
Allograft inflammatory factor 1-like

1

5

High-throughput

0.536

High

1067476

PDLI7
PDZ and LIM domain protein 7

1

8

High-throughput

0.536

High

1067473

WDR76
WD repeat-containing protein 76

2

20

High-throughput

0.533

High

173033

RT12
Small ribosomal subunit protein uS12m

2

1

High-throughput

0.521

High

880253

MAZ
Myc-associated zinc finger protein

2

1

High-throughput

0.521

High

1067457

RBM33
RNA-binding protein 33

2

9

High-throughput

0.521

High

852935

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

6

High-throughput

0.515

High

1067431

SAMD9
Sterile alpha motif domain-containing protein 9

1

3

Small-scale

0.515

High

58756

FUCM
Fucose mutarotase

1

0

High-throughput

0.513

High

517268

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.513

High

1067449

BRK1
Protein BRICK1

1

0

High-throughput

0.513

High

874368

RAD
GTP-binding protein RAD

1

4

Small-scale

0.501

High

1067443

STX12
Syntaxin-12

1

2

Small-scale

0.501

High

1067455

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

High-throughput

0.501

High

790

A0A087WZU1
protein-tyrosine-phosphatase

1

4

High-throughput

0.489

High

169466

BET1
BET1 homolog

1

1

High-throughput

0.489

High

658678

SMCA1
Probable global transcription activator SNF2L1

1

20

High-throughput

0.489

High

1067428

CEA16
Carcinoembryonic antigen-related cell adhesion molecule 16

1

4

High-throughput

0.489

High

1067450

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

1

High-throughput

0.489

High

1067437

CDC73
Parafibromin

1

3

Small-scale

0.481

High

150999

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

12

High-throughput

0.479

High

178540

STX7
Syntaxin-7

1

2

High-throughput

0.479

High

203373

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

3

High-throughput

0.479

High

212836

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

227500

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.479

High

374257

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

14

High-throughput

0.479

High

375745

GBA1
Lysosomal acid glucosylceramidase

1

2

Small-scale

0.479

High

386765

P53
Cellular tumor antigen p53

1

5

Small-scale

0.479

High

391713

H2A1B
Histone H2A type 1-B/E

1

20

High-throughput

0.479

High

514836

MPRI
Cation-independent mannose-6-phosphate receptor

1

2

High-throughput

0.479

High

527460

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.479

High

591852

RAB4A
Ras-related protein Rab-4A

1

3

High-throughput

0.479

High

609875

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

13

High-throughput

0.479

High

813485

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.479

High

841976

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

13

High-throughput

0.479

High

845493

RAB9A
Ras-related protein Rab-9A

1

4

High-throughput

0.479

High

874954

TERA
Transitional endoplasmic reticulum ATPase

1

5

Small-scale

0.479

High

886112

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.479

High

897733

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

911010

RS29
Small ribosomal subunit protein uS14

1

1

High-throughput

0.479

High

917302

H4
Histone H4

1

11

High-throughput

0.479

High

965675

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.479

High

998727

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

1035760

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

1041611

CUL3
Cullin-3

1

10

High-throughput

0.479

High

1049212

KEAP1
Kelch-like ECH-associated protein 1

1

3

High-throughput

0.479

High

1061918

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

9

High-throughput

0.479

High

1066140

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

1067424

PCM1
Pericentriolar material 1 protein

1

1

High-throughput

0.479

High

1067425

RABE1
Rab GTPase-binding effector protein 1

1

15

Small-scale

0.479

High

1067426

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

5

High-throughput

0.479

High

1067429

FBX43
F-box only protein 43

1

1

Small-scale

0.479

High

1067430

RRP12
RRP12-like protein

1

1

High-throughput

0.479

High

1067433

ECM29
Proteasome adapter and scaffold protein ECM29

1

10

High-throughput

0.479

High

1067434

H2A2A
Histone H2A type 2-A

1

20

High-throughput

0.479

High

1067438

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1067442

HAUS6
HAUS augmin-like complex subunit 6

1

1

High-throughput

0.479

High

1067446

SAM9L
Sterile alpha motif domain-containing protein 9-like

1

3

Small-scale

0.479

High

1067453

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

9

High-throughput

0.479

High

1067454

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

13

High-throughput

0.479

High

1067456

FBXW7
F-box/WD repeat-containing protein 7

1

10

High-throughput

0.479

High

1067460

SNX27
Sorting nexin-27

1

13

High-throughput

0.479

High

1067462

RING2
E3 ubiquitin-protein ligase RING2

1

15

High-throughput

0.479

High

1067465

ACE2
Angiotensin-converting enzyme 2

1

7

High-throughput

0.479

High

1067466

GTPB4
GTP-binding protein 4

1

2

High-throughput

0.479

High

1067468

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

1067470

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

1

High-throughput

0.479

High

1067474

GRPE1
GrpE protein homolog 1, mitochondrial

1

1

High-throughput

0.479

High

1067475

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

5

High-throughput

0.479

High

1067478

PDGFC
Platelet-derived growth factor C

1

4

High-throughput

0.479

High

1067482

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1067483

RABX5
Rab5 GDP/GTP exchange factor

1

2

Small-scale

0.479

High

1067484

DP13A
DCC-interacting protein 13-alpha

1

1

High-throughput

0.479

High

1067488

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.479

High

1067489

RUVB1
RuvB-like 1

1

3

High-throughput

0.479

High

201015

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.458

High

1067435

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1067467

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1067477

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

1067487

PPR3C
Protein phosphatase 1 regulatory subunit 3C

1

0

High-throughput

0.458

High

529140

CFTR
Cystic fibrosis transmembrane conductance regulator

1

13

High-throughput

0.445

High

1060754

IMB1
Importin subunit beta-1

1

6

Small-scale

0.445

High

1067427

H2A2C
Histone H2A type 2-C

1

20

High-throughput

0.445

High

1067432

H2B2F
Histone H2B type 2-F

1

20

High-throughput

0.445

High

117277

PDLI1
PDZ and LIM domain protein 1

1

8

High-throughput

0.437

High

229861

KIF5C
Kinesin heavy chain isoform 5C

1

2

High-throughput

0.437

High

321403

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

4

High-throughput

0.437

High

329730

AGR2
Anterior gradient protein 2 homolog

1

5

High-throughput

0.437

High

390899

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

435647

IGF1R
Insulin-like growth factor 1 receptor

1

11

Small-scale

0.437

High

525937

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.437

High

1067440

MOB3C
MOB kinase activator 3C

1

3

High-throughput

0.437

High

1067444

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

17

High-throughput

0.437

High

1067445

LRC49
Leucine-rich repeat-containing protein 49

1

10

High-throughput

0.437

High

1067452

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.437

High

1067471

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

1067486

MRTFB
Myocardin-related transcription factor B

1

9

High-throughput

0.437

High

1067490

LOXL2
Lysyl oxidase homolog 2

1

5

High-throughput

0.437

High

609293

FGFR3
Fibroblast growth factor receptor 3

1

5

High-throughput

0.407

High

1067447

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.279

Low

1067458

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.279

Low

1067436

GP153
Probable G-protein coupled receptor 153

1

0

High-throughput

0.249

Low

1067439

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.249

Low

1067469

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

0

High-throughput

0.249

Low

1067472

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.249

Low

1067479

VPS45
Vacuolar protein sorting-associated protein 45

1

0

High-throughput

0.249

Low

1067480

F135A
Protein FAM135A

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024