Protein: BDNF
Neurotrophic factor BDNF precursor form (proBDNF) (Abrineurin) (Brain-derived neurotrophic factor) [Cleaved into: Neurotrophic factor BDNF]

Gene: BDNF
Organism: Homo sapiens
Interactions: 85
UniProt ID: P23560

Gene Ontology (top 5):
GO:0005163 - nerve growth factor receptor binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

660293

SORT
Sortilin

5

7

Small-scale

0.918

High

660267

NTRK2
BDNF/NT-3 growth factors receptor

3

9

Small-scale

0.858

High

660248

NTF4
Neurotrophin-4

2

5

Small-scale

0.825

High

634959

NTF3
Neurotrophin-3

2

5

Small-scale

0.806

High

593278

PGFRA
Platelet-derived growth factor receptor alpha

1

2

High-throughput

0.691

High

449592

KLK1
Kallikrein-1

1

0

High-throughput

0.656

High

421522

A4
Amyloid-beta precursor protein

2

5

High-throughput

0.611

High

660250

DNSL1
Deoxyribonuclease-1-like 1

2

0

High-throughput

0.594

High

660306

JAM1
Junctional adhesion molecule A

1

0

High-throughput

0.584

High

660292

SORC2
VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain]

1

7

Small-scale

0.579

High

168378

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

High-throughput

0.578

High

660251

HAP1
Huntingtin-associated protein 1

1

0

Small-scale

0.537

High

388693

C1QB
Complement C1q subcomponent subunit B

1

1

High-throughput

0.536

High

660302

CBLN4
Cerebellin-4

1

1

High-throughput

0.536

High

660295

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.518

High

660301

AGO3
Protein argonaute-3

1

0

High-throughput

0.518

High

660275

ATL4
ADAMTS-like protein 4

1

1

High-throughput

0.515

High

660300

TLE6
Transducin-like enhancer protein 6

1

1

High-throughput

0.515

High

660305

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

1

High-throughput

0.515

High

342511

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.513

High

391185

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

567800

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.513

High

635418

C4BPB
C4b-binding protein beta chain

1

0

High-throughput

0.513

High

660252

MFAP4
Microfibril-associated glycoprotein 4

1

0

High-throughput

0.513

High

660261

PTC1
Protein patched homolog 1

1

0

High-throughput

0.513

High

660268

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.513

High

660272

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.513

High

660274

LYZL1
Lysozyme-like protein 1

1

0

High-throughput

0.513

High

660281

FIBIN
Fin bud initiation factor homolog

1

0

High-throughput

0.513

High

660286

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.513

High

660297

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

0

High-throughput

0.513

High

660253

H2BFS
Histone H2B type F-S

1

0

High-throughput

0.493

High

794

A0A087WZY1
Uncharacterized protein

1

0

High-throughput

0.493

High

137183

EXOC5
Exocyst complex component 5

1

0

High-throughput

0.493

High

244642

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.493

High

276670

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

1

0

High-throughput

0.493

High

440374

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.493

High

483435

ANXA4
Annexin A4

1

0

High-throughput

0.493

High

528190

THIO
Thioredoxin

1

0

High-throughput

0.493

High

605556

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

High-throughput

0.493

High

613890

LBP
Lipopolysaccharide-binding protein

1

0

High-throughput

0.493

High

649173

GALA
Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide

1

0

High-throughput

0.493

High

660249

CTNB1
Catenin beta-1

1

0

High-throughput

0.493

High

660254

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

660255

CDK5
Cyclin-dependent kinase 5

1

0

High-throughput

0.493

High

660263

DPYL1
Dihydropyrimidinase-related protein 1

1

0

High-throughput

0.493

High

660264

RAGE
Advanced glycosylation end product-specific receptor

1

0

High-throughput

0.493

High

660266

CYH1
Cytohesin-1

1

0

High-throughput

0.493

High

660278

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

0

High-throughput

0.493

High

660282

PLPR1
Phospholipid phosphatase-related protein type 1

1

0

High-throughput

0.493

High

660284

PRUN2
Protein prune homolog 2

1

0

High-throughput

0.493

High

660287

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.493

High

660304

KAD3
GTP:AMP phosphotransferase AK3, mitochondrial

1

0

High-throughput

0.493

High

214502

HXA3
Homeobox protein Hox-A3

1

1

High-throughput

0.470

High

217842

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

660257

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

3

Small-scale

0.457

High

230261

CREB3
Cyclic AMP-responsive element-binding protein 3

1

1

High-throughput

0.457

High

660262

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

660270

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

660269

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

660283

GP152
Probable G-protein coupled receptor 152

2

0

High-throughput

0.316

High

603614

JUNB
Transcription factor JunB

1

0

High-throughput

0.282

High

426049

PPB1
Alkaline phosphatase, placental type

1

0

High-throughput

0.279

Low

660259

KLRD1
Natural killer cells antigen CD94

1

0

High-throughput

0.279

Low

660256

H11
Histone H1.1

1

0

High-throughput

0.269

Low

450216

HYEP
Epoxide hydrolase 1

1

0

High-throughput

0.268

Low

660258

FUT2
Galactoside alpha-(1,2)-fucosyltransferase 2

1

0

High-throughput

0.268

Low

660260

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.268

Low

660265

UBE3C
Ubiquitin-protein ligase E3C

1

0

High-throughput

0.268

Low

660271

Q6P514
ZNF468 protein

1

0

High-throughput

0.268

Low

660273

CORO6
Coronin-6

1

0

High-throughput

0.268

Low

660277

SNX20
Sorting nexin-20

1

0

High-throughput

0.268

Low

660279

CTL5
Choline transporter-like protein 5

1

0

High-throughput

0.268

Low

660280

GMCL2
Germ cell-less protein-like 2

1

0

High-throughput

0.268

Low

660285

APH1B
Gamma-secretase subunit APH-1B

1

0

High-throughput

0.268

Low

660288

MRAP2
Melanocortin-2 receptor accessory protein 2

1

0

High-throughput

0.268

Low

660289

RUSF1
RUS family member 1

1

0

High-throughput

0.268

Low

660290

S41A3
Solute carrier family 41 member 3

1

0

High-throughput

0.268

Low

660291

HSFY1
Heat shock transcription factor, Y-linked

1

0

High-throughput

0.268

Low

660294

DHRS9
Dehydrogenase/reductase SDR family member 9

1

0

High-throughput

0.268

Low

660296

CCD32
Coiled-coil domain-containing protein 32

1

0

High-throughput

0.268

Low

660298

BTBD1
BTB/POZ domain-containing protein 1

1

0

High-throughput

0.268

Low

660299

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.268

Low

660303

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.268

Low

660276

RHOU
Rho-related GTP-binding protein RhoU

1

0

High-throughput

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025