HitPredict

Interactor 1: AP1B1 (Q10567)
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
Gene: AP1B1

Interactor 2: ARH (Q5SW96)
Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein)
Gene: LDLRAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005829 - cytosol GO:0030276 - clathrin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 949 Hs			1 308
+	Hs
		925893 AP2B1_HUMAN (1-949): 0: 944: 81.45		ARH_HUMAN (1-308): 1.87e-99: 296: 100.00
+	Hs
		833587 AP1B1_HUMAN (1-949): 0: 978: 100.00		NUMB_HUMAN (11-308): 6.78e-59: 201: 19.94
+	Hs
		957123 AP1B1_HUMAN (1-949): 0: 978: 100.00		SHC2_HUMAN (30-308): 2.08e-50: 177: 18.73
+	Hs
		666090 AP1B1_HUMAN (1-949): 0: 978: 100.00		SHC1_HUMAN (1-308): 6.47e-48: 170: 17.42
+	Hs
		833572 AP2B1_HUMAN (1-949): 0: 944: 81.45		NUMB_HUMAN (11-308): 6.78e-59: 201: 19.94
+	Hs
		926067 AP2B1_HUMAN (1-949): 0: 944: 81.45		NUMBL_HUMAN (5-308): 4.79e-59: 200: 18.03
+	Rn
		923852 AP2B1_RAT (1-949): 0: 944: 81.45		Q3MUI1_RAT (11-308): 3.97e-57: 195: 20.07
+	Hs
		253551 AP2B1_HUMAN (1-949): 0: 944: 81.45		CAPON_HUMAN (15-301): 9.66e-57: 192: 22.44
+	Hs
		925962 AP2B1_HUMAN (1-949): 0: 944: 81.45		ANS1A_HUMAN (18-236): 5.57e-50: 179: 18.30
+	Hs
		666058 AP2B1_HUMAN (1-949): 0: 944: 81.45		SHC1_HUMAN (1-308): 6.47e-48: 170: 17.42
+	Hs
		925851 AP2B1_HUMAN (1-949): 0: 944: 81.45		DAB2_HUMAN (40-304): 2.14e-43: 160: 17.13
+	Ce
		283753 Q9N4F3_CAEEL (1-947): 0: 819: 63.06		CED6_CAEEL (7-300): 4.96e-47: 166: 18.89
+	Hs
		321513 AP2A1_HUMAN (12-943): 0: 677: 18.58		NUMB_HUMAN (11-308): 6.78e-59: 201: 19.94
+	Hs
		321527 AP2A1_HUMAN (12-943): 0: 677: 18.58		SHC2_HUMAN (30-308): 2.08e-50: 177: 18.73
+	Hs
		321492 AP2A1_HUMAN (12-943): 0: 677: 18.58		SHC1_HUMAN (1-308): 6.47e-48: 170: 17.42
+	Hs
		321528 AP2A1_HUMAN (12-943): 0: 677: 18.58		DAB2_HUMAN (40-304): 2.14e-43: 160: 17.13
+	Rn
		577194 AP2A2_RAT (12-945): 0: 635: 17.94		Q3MUI1_RAT (11-308): 3.97e-57: 195: 20.07
+	Mm
		567529 AP2A2_MOUSE (12-945): 0: 634: 17.94		ANS1B_MOUSE (2-236): 7.25e-55: 194: 19.28
+	Rn
		1109842 Q66HM2_RAT (12-945): 0: 631: 17.92		Q3MUI1_RAT (11-308): 3.97e-57: 195: 20.07
+	Hs
		302103 AP2A2_HUMAN (12-945): 0: 625: 18.33		SHC1_HUMAN (1-308): 6.47e-48: 170: 17.42