Protein: SHLB1
Endophilin-B1 (Bax-interacting factor 1) (Bif-1) (SH3 domain-containing GRB2-like protein B1)

Gene: SHLB1, SH3GLB1
Organism: Homo sapiens
Interactions: 232
UniProt ID: Q9Y371

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000421 - autophagosome membrane
GO:0005504 - fatty acid binding
GO:0005737 - cytoplasm
GO:0005741 - mitochondrial outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1447959

SHLB2
Endophilin-B2

12

17

Small-scale

0.985

High

1491061

SHLB1
Endophilin-B1

7

16

Small-scale

0.965

High

1388223

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

3

1

High-throughput

0.675

High

1458255

TFP11
Tuftelin-interacting protein 11

4

0

High-throughput

0.668

High

713485

SPB3
Serpin B3

3

2

High-throughput

0.667

High

1060143

BAX
Apoptosis regulator BAX

3

1

Small-scale

0.664

High

1402418

UBL7
Ubiquitin-like protein 7

1

0

High-throughput

0.663

High

920609

ARFP2
Arfaptin-2

3

3

High-throughput

0.660

High

1380458

MAL2
Protein MAL2

3

2

High-throughput

0.660

High

1446623

RIC8A
Chaperone Ric-8A

3

1

High-throughput

0.660

High

215458

TPD54
Tumor protein D54

3

3

High-throughput

0.654

High

1229262

RHG17
Rho GTPase-activating protein 17

1

19

Small-scale

0.647

High

1384311

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

Small-scale

0.647

High

1414546

HTAI2
Protein HTATIP2

3

0

Small-scale

0.646

High

226499

SNG3
Synaptogyrin-3

3

0

High-throughput

0.632

High

1119084

C1D
Nuclear nucleic acid-binding protein C1D

3

0

High-throughput

0.632

High

937515

CDN2D
Cyclin-dependent kinase 4 inhibitor D

1

14

High-throughput

0.621

High

1434818

ZN576
Zinc finger protein 576

3

6

High-throughput

0.616

High

329868

SNX4
Sorting nexin-4

2

1

High-throughput

0.606

High

938087

TPD52
Tumor protein D52

2

3

High-throughput

0.606

High

1112000

SNX1
Sorting nexin-1

2

3

High-throughput

0.606

High

1460198

PRAF1
Prenylated Rab acceptor protein 1

2

2

High-throughput

0.606

High

1449681

ANKE1
Ankyrin repeat and EF-hand domain-containing protein 1

1

9

High-throughput

0.594

High

1454904

UVRAG
UV radiation resistance-associated gene protein

2

0

Small-scale

0.585

High

409142

G3P
Glyceraldehyde-3-phosphate dehydrogenase

2

1

High-throughput

0.584

High

1247438

ATRAP
Type-1 angiotensin II receptor-associated protein

2

0

High-throughput

0.580

High

1259207

SMIM5
Small integral membrane protein 5

2

0

High-throughput

0.580

High

1355983

ABHD5
1-acylglycerol-3-phosphate O-acyltransferase ABHD5

2

0

High-throughput

0.580

High

1412960

DESI2
Deubiquitinase DESI2

2

0

High-throughput

0.580

High

1429523

CLPB
Mitochondrial disaggregase

1

2

High-throughput

0.575

High

665298

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

2

High-throughput

0.573

High

1126792

BECN1
Beclin-1

2

2

Small-scale

0.571

High

1257317

RHEX
Regulator of hemoglobinization and erythroid cell expansion protein

2

1

High-throughput

0.553

High

681088

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.549

High

1309038

FUND1
FUN14 domain-containing protein 1

1

0

High-throughput

0.549

High

479886

GSTP1
Glutathione S-transferase P

1

1

High-throughput

0.541

High

1291014

TAXB1
Tax1-binding protein 1

1

11

High-throughput

0.541

High

1361944

TITIN
Titin

1

5

High-throughput

0.541

High

210212

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

High-throughput

0.536

High

1113033

CUL2
Cullin-2

1

5

High-throughput

0.536

High

1310549

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1371795

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

High-throughput

0.536

High

1460506

SPB13
Serpin B13

1

2

High-throughput

0.536

High

50006

IRGM
Immunity-related GTPase family M protein

1

0

Small-scale

0.529

High

660901

HAP40
40-kDa huntingtin-associated protein

1

0

High-throughput

0.518

High

921587

PGTB2
Geranylgeranyl transferase type-2 subunit beta

1

0

High-throughput

0.518

High

131540

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

4

High-throughput

0.515

High

178863

SCAM1
Secretory carrier-associated membrane protein 1

1

1

High-throughput

0.515

High

181664

CETN3
Centrin-3

1

3

High-throughput

0.515

High

229376

ZBT14
Zinc finger and BTB domain-containing protein 14

1

1

High-throughput

0.515

High

250905

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

4

High-throughput

0.515

High

253123

PLIN3
Perilipin-3

1

1

High-throughput

0.515

High

373566

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.515

High

387342

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.515

High

445469

APOA4
Apolipoprotein A-IV

1

3

High-throughput

0.515

High

483271

CLCA
Clathrin light chain A

1

4

High-throughput

0.515

High

635102

CAN3
Calpain-3

1

5

High-throughput

0.515

High

652441

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.515

High

690730

AOFB
Amine oxidase [flavin-containing] B

1

5

High-throughput

0.515

High

698220

PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A

1

1

High-throughput

0.515

High

833506

PTGDS
Prostaglandin-H2 D-isomerase

1

1

High-throughput

0.515

High

877450

PIPNB
Phosphatidylinositol transfer protein beta isoform

1

2

High-throughput

0.515

High

928597

TERF1
Telomeric repeat-binding factor 1

1

4

High-throughput

0.515

High

970233

UB2G1
Ubiquitin-conjugating enzyme E2 G1

1

2

High-throughput

0.515

High

998983

H31
Histone H3.1

1

2

High-throughput

0.515

High

1024287

PIPNA
Phosphatidylinositol transfer protein alpha isoform

1

2

High-throughput

0.515

High

1066554

RBBP4
Histone-binding protein RBBP4

1

3

High-throughput

0.515

High

1089171

TM115
Transmembrane protein 115

1

1

High-throughput

0.515

High

1111379

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.515

High

1212141

AKCL1
Aldo-keto reductase family 1 member C8

1

4

High-throughput

0.515

High

1219269

Q5VYH9
Lymphocyte antigen 9

1

5

High-throughput

0.515

High

1231711

LEG9C
Galectin-9C

1

3

High-throughput

0.515

High

1251851

PPR21
Protein phosphatase 1 regulatory subunit 21

1

1

High-throughput

0.515

High

1292754

TRI69
E3 ubiquitin-protein ligase TRIM69

1

3

High-throughput

0.515

High

1322326

SPART
Spartin

1

6

High-throughput

0.515

High

1328701

KCD17
BTB/POZ domain-containing protein KCTD17

1

20

High-throughput

0.515

High

1385156

DOC10
Dedicator of cytokinesis protein 10

1

4

High-throughput

0.515

High

1395999

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.515

High

1397798

MAGBI
Melanoma-associated antigen B18

1

4

High-throughput

0.515

High

1397943

KAD8
Adenylate kinase 8

1

1

High-throughput

0.515

High

1410642

TBA1C
Tubulin alpha-1C chain

1

3

High-throughput

0.515

High

1411437

CAB45
45 kDa calcium-binding protein

1

4

High-throughput

0.515

High

1420580

TRIM5
Tripartite motif-containing protein 5

1

4

High-throughput

0.515

High

1437760

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

3

High-throughput

0.515

High

1446863

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

2

High-throughput

0.515

High

1452420

SPHK1
Sphingosine kinase 1

1

1

High-throughput

0.515

High

1452867

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

1

High-throughput

0.515

High

1460938

JUPI1
Jupiter microtubule associated homolog 1

1

1

High-throughput

0.515

High

155372

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.513

High

1105837

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

17

Small-scale

0.512

High

423501

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

1337328

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

6

Small-scale

0.500

High

389577

FINC
Fibronectin

1

2

High-throughput

0.494

High

1461192

ITBP2
Integrin beta-1-binding protein 2

1

1

High-throughput

0.494

High

90570

C1IDX9
Ubiquitin-like protein ATG12

1

0

High-throughput

0.493

High

325626

YIF1A
Protein YIF1A

1

0

High-throughput

0.493

High

332777

EPM2A
Laforin

1

0

High-throughput

0.493

High

378885

CD4
T-cell surface glycoprotein CD4

1

0

High-throughput

0.493

High

505897

JMJD7
Bifunctional peptidase and

1

0

High-throughput

0.493

High

528927

CP2C8
Cytochrome P450 2C8

1

0

High-throughput

0.493

High

617265

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

High-throughput

0.493

High

663509

PRPH2
Peripherin-2

1

0

High-throughput

0.493

High

852655

ABCG1
ATP-binding cassette sub-family G member 1

1

0

High-throughput

0.493

High

885187

TTPA
Alpha-tocopherol transfer protein

1

0

High-throughput

0.493

High

890180

FLT3L
Fms-related tyrosine kinase 3 ligand

1

0

High-throughput

0.493

High

922798

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.493

High

977422

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.493

High

1120080

BAAT
Bile acid-CoA:amino acid N-acyltransferase

1

0

High-throughput

0.493

High

1122783

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.493

High

1200554

CYBR1
Plasma membrane ascorbate-dependent reductase CYBRD1

1

0

High-throughput

0.493

High

1243147

Q6P7E6
Fucosyltransferase

1

0

High-throughput

0.493

High

1272923

3BP5L
SH3 domain-binding protein 5-like

1

0

High-throughput

0.493

High

1358043

TM171
Transmembrane protein 171

1

0

High-throughput

0.493

High

1359674

GIMA1
GTPase IMAP family member 1

1

0

High-throughput

0.493

High

1361968

BSND
Barttin

1

0

High-throughput

0.493

High

1385363

MID49
Mitochondrial dynamics protein MID49

1

0

High-throughput

0.493

High

1389849

SIM12
Small integral membrane protein 12

1

0

High-throughput

0.493

High

1400602

ALKB3
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

1

0

High-throughput

0.493

High

1409759

SPI2B
Spindlin-2B

1

0

High-throughput

0.493

High

1414832

MTNA
Methylthioribose-1-phosphate isomerase

1

0

High-throughput

0.493

High

1420126

SHP1L
Testicular spindle-associated protein SHCBP1L

1

0

High-throughput

0.493

High

1432457

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.493

High

1432682

GHITM
Growth hormone-inducible transmembrane protein

1

0

High-throughput

0.493

High

1435924

NAA60
N-alpha-acetyltransferase 60

1

0

High-throughput

0.493

High

1446866

FERY3
Ferry endosomal RAB5 effector complex subunit 3

1

0

High-throughput

0.493

High

1449131

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.493

High

1459861

CIDEB
Lipid transferase CIDEB

1

0

High-throughput

0.493

High

1460553

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.493

High

270695

ATP9A
Probable phospholipid-transporting ATPase IIA

1

2

High-throughput

0.489

High

1288398

TLK2
Serine/threonine-protein kinase tousled-like 2

1

4

High-throughput

0.489

High

1491062

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

1491063

RPKL1
Ribosomal protein S6 kinase-like 1

1

7

High-throughput

0.489

High

332188

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

2

High-throughput

0.481

High

1447244

EXOS5
Exosome complex component RRP46

1

2

High-throughput

0.481

High

164139

NDC80
Kinetochore protein NDC80 homolog

1

10

High-throughput

0.479

High

365500

PGK1
Phosphoglycerate kinase 1

1

2

High-throughput

0.479

High

556437

CADH1
Cadherin-1

1

7

High-throughput

0.479

High

631583

RAB5A
Ras-related protein Rab-5A

1

7

Small-scale

0.479

High

831686

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

964085

COPZ1
Coatomer subunit zeta-1

1

1

High-throughput

0.479

High

1025531

CDK5
Cyclin-dependent kinase 5

1

2

High-throughput

0.479

High

1141082

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

1144333

STK38
Serine/threonine-protein kinase 38

1

6

High-throughput

0.479

High

1156440

SEPT7
Septin-7

1

3

High-throughput

0.479

High

1244749

KLD10
Kelch domain-containing protein 10

1

1

High-throughput

0.479

High

1256202

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

1364721

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1394642

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

9

Small-scale

0.479

High

1436725

GORS2
Golgi reassembly-stacking protein 2

1

14

High-throughput

0.479

High

1490811

RRP44
Exosome complex exonuclease RRP44

1

1

High-throughput

0.479

High

116318

H3BQL7
SIN3 transcription regulator family member A

1

1

High-throughput

0.470

High

137348

ELL2
RNA polymerase II elongation factor ELL2

1

7

High-throughput

0.470

High

261326

NSMA
Sphingomyelin phosphodiesterase 2

1

3

High-throughput

0.470

High

353640

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.470

High

369524

AACT
Alpha-1-antichymotrypsin

1

2

High-throughput

0.470

High

387762

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

1

High-throughput

0.470

High

388854

APOH
Beta-2-glycoprotein 1

1

1

High-throughput

0.470

High

666936

CCNC
Cyclin-C

1

3

High-throughput

0.470

High

848592

MAGA8
Melanoma-associated antigen 8

1

4

High-throughput

0.470

High

1185842

ZN829
Zinc finger protein 829

1

3

High-throughput

0.470

High

1232352

Q6FGS1
TPD52L2 protein

1

3

High-throughput

0.470

High

1239493

H3C
Histone H3.3C

1

2

High-throughput

0.470

High

1416646

SUCR1
Succinate receptor 1

1

3

High-throughput

0.470

High

1460930

CCNL1
Cyclin-L1

1

4

High-throughput

0.470

High

249534

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

0

Small-scale

0.458

High

551350

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

1452040

TRM1
tRNA

1

0

High-throughput

0.458

High

1490625

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.458

High

223570

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

1

16

High-throughput

0.445

High

530633

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.445

High

582125

PGAM2
Phosphoglycerate mutase 2

1

2

High-throughput

0.445

High

839113

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

6

High-throughput

0.445

High

894449

MMP14
Matrix metalloproteinase-14

1

1

High-throughput

0.445

High

1105118

TCOF
Treacle protein

1

15

High-throughput

0.445

High

1108305

SQSTM
Sequestosome-1

1

3

High-throughput

0.445

High

1125424

FLNC
Filamin-C

1

14

High-throughput

0.445

High

1380794

RL36L
Ribosomal protein eL42-like

1

2

High-throughput

0.445

High

1392117

TOE1
Target of EGR1 protein 1

1

2

High-throughput

0.445

High

1397023

TRI47
E3 ubiquitin-protein ligase TRIM47

1

4

High-throughput

0.445

High

1431355

ATG5
Autophagy protein 5

1

1

High-throughput

0.445

High

1449934

DDX28
Probable ATP-dependent RNA helicase DDX28

1

4

High-throughput

0.445

High

1403056

SIN3A
Paired amphipathic helix protein Sin3a

1

1

High-throughput

0.439

High

1233599

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.437

High

1242064

SCYL2
SCY1-like protein 2

1

7

High-throughput

0.437

High

1256644

CE128
Centrosomal protein of 128 kDa

1

10

High-throughput

0.437

High

1450367

SEP11
Septin-11

1

3

High-throughput

0.437

High

1459822

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

1

High-throughput

0.437

High

239255

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.426

High

568709

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.426

High

772639

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.426

High

1333376

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.426

High

1383193

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.426

High

330381

VENTX
Homeobox protein VENTX

1

6

High-throughput

0.407

High

954662

GPR85
Probable G-protein coupled receptor 85

1

9

High-throughput

0.407

High

1104171

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

1341174

WDR36
WD repeat-containing protein 36

1

3

High-throughput

0.407

High

1392272

DDX27
Probable ATP-dependent RNA helicase DDX27

1

2

High-throughput

0.407

High

1341353

COQ8A
Atypical kinase COQ8A, mitochondrial

4

0

High-throughput

0.366

High

469574

SYPH
Synaptophysin

3

0

High-throughput

0.344

High

939551

FCGRN
IgG receptor FcRn large subunit p51

2

0

High-throughput

0.328

High

1449016

F1142
Protein FAM114A2

2

0

High-throughput

0.316

High

1459646

FLOWR
Calcium channel flower homolog

2

0

High-throughput

0.316

High

63840

PEDS1
Plasmanylethanolamine desaturase 1

1

0

High-throughput

0.268

Low

168141

TIM23
Mitochondrial import inner membrane translocase subunit Tim23

1

0

High-throughput

0.268

Low

179007

NPFF
Pro-FMRFamide-related neuropeptide FF

1

0

High-throughput

0.268

Low

280971

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.268

Low

299709

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

0

High-throughput

0.268

Low

390348

CXCL7
Platelet basic protein

1

0

High-throughput

0.268

Low

670088

NFYB
Nuclear transcription factor Y subunit beta

1

0

High-throughput

0.268

Low

744693

TF2H1
General transcription factor IIH subunit 1

1

0

High-throughput

0.268

Low

1165358

SYT16
Synaptotagmin-16

1

0

High-throughput

0.268

Low

1198874

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

0

High-throughput

0.268

Low

1200216

Q53NU3
cDNA, FLJ92284

1

0

High-throughput

0.268

Low

1229491

NCAS2
Protein NCBP2AS2

1

0

High-throughput

0.268

Low

1279320

AB12B
Protein ABHD12B

1

0

High-throughput

0.268

Low

1317058

FAM9A
Protein FAM9A

1

0

High-throughput

0.268

Low

1322733

F177A
Protein FAM177A1

1

0

High-throughput

0.268

Low

1323288

CD033
UPF0462 protein C4orf33

1

0

High-throughput

0.268

Low

1324897

MUC15
Mucin-15

1

0

High-throughput

0.268

Low

1340976

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.268

Low

1386095

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

0

High-throughput

0.268

Low

1393463

REEP6
Receptor expression-enhancing protein 6

1

0

High-throughput

0.268

Low

1397077

DHRS1
Dehydrogenase/reductase SDR family member 1

1

0

High-throughput

0.268

Low

1416312

SFXN3
Sideroflexin-3

1

0

High-throughput

0.268

Low

1459585

CRCT1
Cysteine-rich C-terminal protein 1

1

0

High-throughput

0.268

Low

925997

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.249

Low

1013188

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.249

Low

1365537

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.249

Low

1367765

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.249

Low

1332261

KRI1
Protein KRI1 homolog

1

0

High-throughput

0.232

Low

1415201

TM109
Voltage-gated monoatomic cation channel TMEM109

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025