Protein: SH3G3
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)

Gene: SH3G3, SH3GL3
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q99963

Gene Ontology (top 5):
GO:0001669 - acrosomal vesicle
GO:0005737 - cytoplasm
GO:0006897 - endocytosis
GO:0007165 - signal transduction
GO:0007417 - central nervous system development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1408372

SH3G1
Endophilin-A2

7

17

Small-scale

0.971

High

1408389

SH3G2
Endophilin-A1

5

17

Small-scale

0.936

High

1408407

SH3G3
Endophilin-A3

3

16

Small-scale

0.871

High

363778

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

1258041

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

2

19

Small-scale

0.819

High

1017538

RHG08
Rho GTPase-activating protein 8

2

20

High-throughput

0.789

High

436723

KPCB
Protein kinase C beta type

2

6

High-throughput

0.737

High

1394597

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

12

High-throughput

0.737

High

1406472

ATX2
Ataxin-2

3

20

Small-scale

0.688

High

843915

HD
Huntingtin

3

10

Small-scale

0.682

High

177302

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

2

2

High-throughput

0.659

High

931705

RD23B
UV excision repair protein RAD23 homolog B

2

13

High-throughput

0.659

High

1140193

ARHG6
Rho guanine nucleotide exchange factor 6

1

19

High-throughput

0.656

High

1363731

SHC3
SHC-transforming protein 3

1

20

High-throughput

0.656

High

1384253

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

Small-scale

0.649

High

242720

PRKN
E3 ubiquitin-protein ligase parkin

1

10

Small-scale

0.625

High

1408411

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

16

High-throughput

0.625

High

611961

RL35A
Large ribosomal subunit protein eL33

2

2

High-throughput

0.620

High

65927

NCF1B
Putative neutrophil cytosol factor 1B

1

20

High-throughput

0.618

High

85494

B7ZMA4
LOC553158 protein

1

20

High-throughput

0.618

High

572848

NCF1
Neutrophil cytosol factor 1

1

20

High-throughput

0.618

High

1408425

DYN3
Dynamin-3

1

20

Small-scale

0.618

High

1117455

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

High-throughput

0.595

High

440701

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.590

High

72898

B1AHC3
PRR5-ARHGAP8 readthrough

1

20

High-throughput

0.575

High

896873

DYN2
Dynamin-2

1

20

Small-scale

0.575

High

65313

RFOX3
RNA binding protein fox-1 homolog 3

2

7

High-throughput

0.571

High

161077

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

2

20

High-throughput

0.571

High

211405

RFOX2
RNA binding protein fox-1 homolog 2

2

9

High-throughput

0.571

High

359724

DHE3
Glutamate dehydrogenase 1, mitochondrial

2

2

High-throughput

0.571

High

415819

HSPB1
Heat shock protein beta-1

2

3

High-throughput

0.571

High

445248

S10A6
Protein S100-A6

2

6

High-throughput

0.571

High

476188

ANXA5
Annexin A5

2

4

High-throughput

0.571

High

531132

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

5

High-throughput

0.571

High

542806

G6PD
Glucose-6-phosphate 1-dehydrogenase

2

1

High-throughput

0.571

High

566020

EF2
Elongation factor 2

2

5

High-throughput

0.571

High

587786

DESP
Desmoplakin

2

18

High-throughput

0.571

High

646924

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

2

1

High-throughput

0.571

High

647638

UBA1
Ubiquitin-like modifier-activating enzyme 1

2

1

High-throughput

0.571

High

683610

ITA3
Integrin alpha-3

2

3

High-throughput

0.571

High

687294

HMGB2
High mobility group protein B2

2

6

High-throughput

0.571

High

716392

BLVRB
Flavin reductase

2

1

High-throughput

0.571

High

908451

HDGF
Hepatoma-derived growth factor

2

1

High-throughput

0.571

High

953977

IF4A1
Eukaryotic initiation factor 4A-I

2

9

High-throughput

0.571

High

992638

IF5A1
Eukaryotic translation initiation factor 5A-1

2

2

High-throughput

0.571

High

993905

TYB10
Thymosin beta-10

2

1

High-throughput

0.571

High

1039984

AKA12
A-kinase anchor protein 12

2

10

High-throughput

0.571

High

1118146

DX39B
Spliceosome RNA helicase DDX39B

2

7

High-throughput

0.571

High

1144303

STK38
Serine/threonine-protein kinase 38

2

9

High-throughput

0.571

High

1161050

FSCN1
Fascin

2

1

High-throughput

0.571

High

1365220

HS105
Heat shock protein 105 kDa

2

10

High-throughput

0.571

High

1408417

RFOX1
RNA binding protein fox-1 homolog 1

2

7

High-throughput

0.571

High

1380637

FBX32
F-box only protein 32

1

2

Small-scale

0.561

High

717228

KCY
UMP-CMP kinase

2

0

High-throughput

0.547

High

954595

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

0

High-throughput

0.547

High

985535

RL32
Large ribosomal subunit protein eL32

2

0

High-throughput

0.547

High

1142457

PA1B3
Platelet-activating factor acetylhydrolase IB subunit alpha1

2

0

High-throughput

0.547

High

1404886

PARK7
Parkinson disease protein 7

2

0

High-throughput

0.547

High

296863

GABR2
Gamma-aminobutyric acid type B receptor subunit 2

1

1

High-throughput

0.541

High

894309

CRIP1
Cysteine-rich protein 1

1

13

High-throughput

0.541

High

895006

EMD
Emerin

1

1

High-throughput

0.541

High

928533

TERF1
Telomeric repeat-binding factor 1

1

5

High-throughput

0.541

High

991233

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

20

High-throughput

0.541

High

1392097

TOE1
Target of EGR1 protein 1

1

2

High-throughput

0.541

High

1408419

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

13

High-throughput

0.541

High

625583

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.536

High

224351

BUB3
Mitotic checkpoint protein BUB3

2

1

High-throughput

0.521

High

262563

MCE1
mRNA-capping enzyme

2

3

High-throughput

0.521

High

481370

HMGB1
High mobility group protein B1

2

6

High-throughput

0.521

High

487683

PARP1
Poly [ADP-ribose] polymerase 1

2

4

High-throughput

0.521

High

687856

SYVC
Valine--tRNA ligase

2

1

High-throughput

0.521

High

786226

LONM
Lon protease homolog, mitochondrial

2

5

High-throughput

0.521

High

882841

EFTU
Elongation factor Tu, mitochondrial

2

3

High-throughput

0.521

High

883474

DHE4
Glutamate dehydrogenase 2, mitochondrial

2

2

High-throughput

0.521

High

963010

CH10
10 kDa heat shock protein, mitochondrial

2

3

High-throughput

0.521

High

1014028

RL36A
Large ribosomal subunit protein eL42

2

2

High-throughput

0.521

High

1092633

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

2

5

High-throughput

0.521

High

1094249

ACACA
Acetyl-CoA carboxylase 1

2

1

High-throughput

0.521

High

1124296

IF4A2
Eukaryotic initiation factor 4A-II

2

6

High-throughput

0.521

High

1204791

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

2

20

High-throughput

0.521

High

1235214

IF5AL
Eukaryotic translation initiation factor 5A-1-like

2

2

High-throughput

0.521

High

1242036

SCYL2
SCY1-like protein 2

2

7

High-throughput

0.521

High

1380724

RL36L
Ribosomal protein eL42-like

2

2

High-throughput

0.521

High

1408409

SPNDC
Spindlin interactor and repressor of chromatin-binding protein

2

1

High-throughput

0.521

High

1408424

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

2

8

High-throughput

0.521

High

1408426

RCL1
RNA 3'-terminal phosphate cyclase-like protein

2

1

High-throughput

0.521

High

1408427

TR150
Thyroid hormone receptor-associated protein 3

2

9

High-throughput

0.521

High

352727

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.513

High

474932

VIME
Vimentin

1

20

High-throughput

0.508

High

1163804

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

8

High-throughput

0.508

High

1365287

SEPT8
Septin-8

1

4

High-throughput

0.508

High

1408423

CBLC
E3 ubiquitin-protein ligase CBL-C

1

20

High-throughput

0.508

High

869516

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

5

Small-scale

0.501

High

1209569

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

Small-scale

0.501

High

1408415

DNJC5
DnaJ homolog subfamily C member 5

1

8

High-throughput

0.501

High

155873

DPYL4
Dihydropyrimidinase-related protein 4

1

3

High-throughput

0.494

High

912601

GDIR1
Rho GDP-dissociation inhibitor 1

1

2

High-throughput

0.494

High

1061845

TLE5
TLE family member 5

1

1

High-throughput

0.494

High

1271212

DPPA4
Developmental pluripotency-associated protein 4

1

4

High-throughput

0.494

High

1308075

EGFL6
Epidermal growth factor-like protein 6

1

4

High-throughput

0.494

High

1371818

IGSF2
Immunoglobulin superfamily member 2

1

6

High-throughput

0.494

High

1408413

WDR33
pre-mRNA 3' end processing protein WDR33

1

2

High-throughput

0.494

High

1408422

PRAF1
Prenylated Rab acceptor protein 1

1

2

High-throughput

0.481

High

466957

ACM4
Muscarinic acetylcholine receptor M4

1

20

Small-scale

0.479

High

477196

ADA2A
Alpha-2A adrenergic receptor

1

20

Small-scale

0.479

High

651423

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.479

High

1308747

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

20

High-throughput

0.479

High

1027698

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

4

High-throughput

0.470

High

1324588

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.460

High

49691

T120B
Transmembrane protein 120B

1

1

High-throughput

0.439

High

302620

RNF8
E3 ubiquitin-protein ligase RNF8

1

6

High-throughput

0.439

High

1408430

GOT1B
Vesicle transport protein GOT1B

1

1

High-throughput

0.439

High

569046

ADRB3
Beta-3 adrenergic receptor

1

7

Small-scale

0.437

High

770815

HRH1
Histamine H1 receptor

1

20

Small-scale

0.437

High

771645

DRD3
D(3) dopamine receptor

1

18

Small-scale

0.437

High

1229056

RNF43
E3 ubiquitin-protein ligase RNF43

1

17

High-throughput

0.437

High

1233448

LTOR1
Ragulator complex protein LAMTOR1

1

5

High-throughput

0.437

High

1385843

CHM4C
Charged multivesicular body protein 4c

1

4

High-throughput

0.437

High

772053

K1C9
Keratin, type I cytoskeletal 9

1

20

High-throughput

0.417

High

1408429

SNX24
Sorting nexin-24

1

8

High-throughput

0.417

High

73882

HGB1A
High mobility group protein B1-like 1

1

5

High-throughput

0.407

High

469327

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

2

0

High-throughput

0.298

High

644545

PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase

2

0

High-throughput

0.298

High

724797

METK2
S-adenosylmethionine synthase isoform type-2

2

0

High-throughput

0.298

High

728970

PUR9
Bifunctional purine biosynthesis protein ATIC

2

0

High-throughput

0.298

High

904091

BAP31
B-cell receptor-associated protein 31

2

0

High-throughput

0.298

High

1023607

CYC
Cytochrome c

2

0

High-throughput

0.298

High

1095221

MTAP
S-methyl-5'-thioadenosine phosphorylase

2

0

High-throughput

0.298

High

1130965

BMS1
Ribosome biogenesis protein BMS1 homolog

2

0

High-throughput

0.298

High

1162114

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

2

0

High-throughput

0.298

High

1338170

PPHLN
Periphilin-1

2

0

High-throughput

0.298

High

1382280

RM24
Large ribosomal subunit protein uL24m

2

0

High-throughput

0.298

High

1408412

RM32
Large ribosomal subunit protein bL32m

2

0

High-throughput

0.298

High

1408416

RT18A
Large ribosomal subunit protein mL66

2

0

High-throughput

0.298

High

1408418

MAT2B
Methionine adenosyltransferase 2 subunit beta

2

0

High-throughput

0.298

High

1408420

SUN2
SUN domain-containing protein 2

2

0

High-throughput

0.298

High

1408421

DPP2
Dipeptidyl peptidase 2

2

0

High-throughput

0.298

High

1408428

MEMO1
Protein MEMO1

2

0

High-throughput

0.298

High

184219

RER1
Protein RER1

1

0

High-throughput

0.282

High

1198884

CD017
Uncharacterized protein C4orf17

1

0

High-throughput

0.282

High

1408408

ANKMT
Adenine nucleotide translocase lysine N-methyltransferase

1

0

High-throughput

0.282

High

1408410

TGT
Queuine tRNA-ribosyltransferase catalytic subunit 1

1

0

High-throughput

0.282

High

1408414

CK068
UPF0696 protein C11orf68

1

0

High-throughput

0.282

High

1408431

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

1

0

High-throughput

0.282

High

568585

TNNT1
Troponin T, slow skeletal muscle

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025