HitPredict

Interactor 1: AP1B1 (Q10567)
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
Gene: AP1B1

Interactor 2: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.964

Property	Details
Experiments	7593184, 35235311, 26186194, 28514442, 33961781, 19380743, 24189400
Identification Methods	two hybrid, cross-linking study, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Adap_comp_sub~Adaptin_N, Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0005765 - lysosomal membrane GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0016192 - vesicle-mediated transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 949 Hs			1 435
+	Hs
		1014074 AP1B1_HUMAN (1-949): 0: 978: 100.00		AP1M1_HUMAN (2-434): 5.69e-170: 484: 38.85
+	Hs
		925969 AP2B1_HUMAN (1-949): 0: 944: 81.45		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Hs
		1014107 AP1B1_HUMAN (1-949): 0: 978: 100.00		AP1M2_HUMAN (2-434): 5.35e-163: 467: 37.70
+	Hs
		925992 AP2B1_HUMAN (1-949): 0: 944: 81.45		AP1M1_HUMAN (2-434): 5.69e-170: 484: 38.85
+	Hs
		926066 AP2B1_HUMAN (1-949): 0: 944: 81.45		AP1M2_HUMAN (2-434): 5.35e-163: 467: 37.70
+	Dm
		248295 Q24253_DROME (1-949): 0: 851: 72.74		O62530_DROME (1-435): 7.78e-171: 487: 86.56
+	Ce
		725366 Q9N4F3_CAEEL (1-947): 0: 819: 63.06		AP2M_CAEEL (1-435): 3.73e-172: 491: 80.95
+	Ce
		725358 Q9N4F3_CAEEL (1-947): 0: 819: 63.06		AP1M_CAEEL (3-434): 9.63e-161: 461: 39.86
+	At
		187750 APBLC_ARATH (3-948): 0: 788: 57.01		AP2M_ARATH (2-435): 8.67e-160: 459: 47.27
+	At
		187886 APBLB_ARATH (3-948): 0: 774: 56.69		AP2M_ARATH (2-435): 8.67e-160: 459: 47.27
+	Hs
		1014058 AP1B1_HUMAN (1-949): 0: 978: 100.00		STON2_HUMAN (146-433): 1.58e-62: 219: 22.85
+	Hs
		321614 AP2A1_HUMAN (12-943): 0: 677: 18.58		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Hs
		925959 AP2B1_HUMAN (1-949): 0: 944: 81.45		STON2_HUMAN (146-433): 1.58e-62: 219: 22.85
+	Rn
		577193 AP2A2_RAT (12-945): 0: 635: 17.94		AP2M1_RAT (1-435): 1.03e-178: 507: 100.00
+	Hs
		302192 AP2A2_HUMAN (12-945): 0: 625: 18.33		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Dm
		248292 AP2A_DROME (12-943): 0: 608: 16.06		O62530_DROME (1-435): 7.78e-171: 487: 86.56
+	At
		187823 AP2A1_ARATH (13-946): 0: 627: 16.87		AP2M_ARATH (2-435): 8.67e-160: 459: 47.27
+	At
		187822 AP2A2_ARATH (13-946): 0: 621: 16.87		AP2M_ARATH (2-435): 8.67e-160: 459: 47.27
+	Hs
		212655 AP1G1_HUMAN (12-822): 0: 556: 17.29		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Mm
		612130 AP1G1_MOUSE (12-822): 0: 557: 17.17		AP1M1_MOUSE (2-434): 2e-169: 483: 38.62