HitPredict

Interactor 1: AP1B1 (Q10567)
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
Gene: AP1B1

Interactor 2: EP15R (Q9UBC2)
Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)
Gene: EPS15L1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 949 Hs			1 864
+	Hs
		926038 AP2B1_HUMAN (1-949): 0: 944: 81.45		EP15R_HUMAN (1-864): 1.18e-150: 466: 100.00
+	Hs
		787903 AP1B1_HUMAN (1-949): 0: 978: 100.00		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Hs
		787890 AP2B1_HUMAN (1-949): 0: 944: 81.45		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Mm
		788007 AP2B1_MOUSE (1-949): 0: 944: 81.35		EPS15_MOUSE (1-862): 8.21e-97: 325: 41.30
+	Rn
		923853 AP2B1_RAT (1-949): 0: 944: 81.45		Q5JC29_RAT (1-782): 2.53e-93: 313: 42.20
+	Hs
		321661 AP2A1_HUMAN (12-943): 0: 677: 18.58		EP15R_HUMAN (1-864): 1.18e-150: 466: 100.00
+	Hs
		1014017 AP1B1_HUMAN (1-949): 0: 978: 100.00		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Hs
		1014096 AP1B1_HUMAN (1-949): 0: 978: 100.00		ITSN2_HUMAN (2-531): 1.52e-24: 112: 11.86
+	Hs
		925876 AP2B1_HUMAN (1-949): 0: 944: 81.45		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Rn
		923861 AP2B1_RAT (1-949): 0: 944: 81.45		ITSN1_RAT (16-526): 9.71e-29: 126: 12.87
+	Hs
		926031 AP2B1_HUMAN (1-949): 0: 944: 81.45		ITSN2_HUMAN (2-531): 1.52e-24: 112: 11.86
+	Hs
		321504 AP2A1_HUMAN (12-943): 0: 677: 18.58		EPS15_HUMAN (1-862): 3.59e-115: 374: 42.20
+	Rn
		88764 D3ZUY8_RAT (12-943): 0: 670: 18.03		Q5JC29_RAT (1-782): 2.53e-93: 313: 42.20
+	Ce
		1341625 Q9N4F3_CAEEL (1-947): 0: 819: 63.06		Q9U2T9_CAEEL (119-652): 4.86e-35: 146: 17.92
+	Mm
		567515 AP2A2_MOUSE (12-945): 0: 634: 17.94		EPS15_MOUSE (1-862): 8.21e-97: 325: 41.30
+	Rn
		1126749 Q66HM2_RAT (12-945): 0: 631: 17.92		Q5JC29_RAT (1-782): 2.53e-93: 313: 42.20
+	Hs
		321552 AP2A1_HUMAN (12-943): 0: 677: 18.58		ITSN1_HUMAN (1-522): 2.39e-32: 138: 13.31
+	Rn
		88768 D3ZUY8_RAT (12-943): 0: 670: 18.03		ITSN1_RAT (16-526): 9.71e-29: 126: 12.87
+	Hs
		321640 AP2A1_HUMAN (12-943): 0: 677: 18.58		EHD1_HUMAN (198-366): 4.94e-14: 77.8: 25.44
+	Hs
		321600 AP2A1_HUMAN (12-943): 0: 677: 18.58		REPS2_HUMAN (14-99): 3.33e-12: 72.3: 24.42