Protein: CBX5
Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha)

Gene: CBX5
Organism: Mus musculus
Interactions: 70
UniProt ID: Q61686

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000776 - kinetochore
GO:0000781 - chromosome, telomeric region
GO:0000792 - heterochromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1223213

TIF1B
Transcription intermediary factor 1-beta

5

20

Small-scale

0.925

High

1223214

TIF1A
Transcription intermediary factor 1-alpha

2

20

Small-scale

0.808

High

1223236

TRI66
Tripartite motif-containing protein 66

1

20

Small-scale

0.740

High

236521

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

20

Small-scale

0.724

High

1223225

SENP7
Sentrin-specific protease 7

3

8

Small-scale

0.667

High

1017356

H33
Histone H3.3

1

20

Small-scale

0.647

High

1223211

CBX5
Chromobox protein homolog 5

1

19

Small-scale

0.647

High

1223242

CAF1A
Chromatin assembly factor 1 subunit A

3

12

Small-scale

0.640

High

1014252

CBX1
Chromobox protein homolog 1

1

19

High-throughput

0.618

High

1016758

H32
Histone H3.2

1

20

High-throughput

0.618

High

1223216

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

1223240

Q9DCC5
Cbx3 protein

1

19

High-throughput

0.618

High

980651

H4
Histone H4

2

13

Small-scale

0.595

High

1223222

Q6ZQ47
Activity-dependent neuroprotector homeobox protein

2

10

Small-scale

0.584

High

1223239

CAF1B
Chromatin assembly factor 1 subunit B

2

11

Small-scale

0.584

High

1223237

HDAC9
Histone deacetylase 9

1

3

Small-scale

0.573

High

846994

H14
Histone H1.4

1

15

Small-scale

0.561

High

872999

SOX2
Transcription factor SOX-2

1

16

High-throughput

0.561

High

1189957

LBR
Delta(14)-sterol reductase LBR

1

3

Small-scale

0.501

High

59078

A2A7F4
Rearranged L-myc fusion sequence

1

20

High-throughput

0.479

High

73072

ZN462
Zinc finger protein 462

1

20

High-throughput

0.479

High

73952

Z518A
Zinc finger protein 518A

1

20

High-throughput

0.479

High

117096

J3QPN0
Zinc finger protein 518B

1

20

High-throughput

0.479

High

847017

H11
Histone H1.1

1

15

High-throughput

0.479

High

876528

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C]

1

7

Small-scale

0.479

High

881004

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

6

High-throughput

0.479

High

945963

EF2
Elongation factor 2

1

2

High-throughput

0.479

High

947436

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

18

High-throughput

0.479

High

973648

RS11
Small ribosomal subunit protein uS17

1

2

High-throughput

0.479

High

977439

RS4X
Small ribosomal subunit protein eS4

1

1

High-throughput

0.479

High

978809

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

981760

RAN
GTP-binding nuclear protein Ran

1

4

High-throughput

0.479

High

982903

RS24
Small ribosomal subunit protein eS24

1

2

High-throughput

0.479

High

989974

1433Z
14-3-3 protein zeta/delta

1

8

High-throughput

0.479

High

995517

RL22
Large ribosomal subunit protein eL22

1

2

High-throughput

0.479

High

1015170

ERH
Enhancer of rudimentary homolog

1

2

High-throughput

0.479

High

1222062

RBBP4
Histone-binding protein RBBP4

1

16

High-throughput

0.479

High

1222425

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

Small-scale

0.479

High

1223212

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

1

1

Small-scale

0.479

High

1223215

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

20

High-throughput

0.479

High

1223217

RBL2
Retinoblastoma-like protein 2

1

10

Small-scale

0.479

High

1223218

Z280D
Zinc finger protein 280D

1

20

High-throughput

0.479

High

1223219

Z280C
Zinc finger protein 280C

1

20

High-throughput

0.479

High

1223220

AHDC1
Transcription factor Gibbin

1

6

High-throughput

0.479

High

1223226

POGZ
Pogo transposable element with ZNF domain

1

20

High-throughput

0.479

High

1223229

SCAI
Protein SCAI

1

4

High-throughput

0.479

High

1223230

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

6

High-throughput

0.479

High

1223231

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

9

High-throughput

0.479

High

1223232

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.479

High

1223233

REST
RE1-silencing transcription factor

1

20

High-throughput

0.479

High

1223234

GLYR1
Cytokine-like nuclear factor N-PAC

1

14

High-throughput

0.479

High

1223235

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

6

Small-scale

0.479

High

1223238

PCGF6
Polycomb group RING finger protein 6

1

20

High-throughput

0.479

High

1223243

INCE
Inner centromere protein

1

20

High-throughput

0.479

High

1223244

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

20

Small-scale

0.479

High

1223245

MECP2
Methyl-CpG-binding protein 2

1

18

Small-scale

0.479

High

1223246

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

8

High-throughput

0.479

High

390

AUTS2
Autism susceptibility gene 2 protein homolog

1

11

Small-scale

0.445

High

915611

HMGA2
High mobility group protein HMGI-C

1

3

High-throughput

0.445

High

59867

MGAP
MAX gene-associated protein

1

9

High-throughput

0.437

High

893590

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

1

3

High-throughput

0.437

High

1223224

M18BP
Mis18-binding protein 1

1

3

High-throughput

0.437

High

1223227

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.437

High

1223228

Q8C1L2
Zinc finger protein 998

1

20

High-throughput

0.437

High

999082

1433F
14-3-3 protein eta

1

8

High-throughput

0.407

High

985107

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.249

Low

1223221

PAQR6
Membrane progestin receptor delta

1

0

Small-scale

0.249

Low

1223223

RIMS3
Regulating synaptic membrane exocytosis protein 3

1

0

Small-scale

0.249

Low

1223241

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025