HitPredict

Interactor 1: F8VWT9 (F8VWT9)
HECT domain E3 ubiquitin protein ligase 4
Gene: HECTD4

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4284 Hs			1 245
+	Hs
		101690 F8VWT9_HUMAN (1-4284): 0: 8395: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		101682 F8VWT9_HUMAN (1-4284): 0: 8395: 100.00		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		101693 F8VWT9_HUMAN (1-4284): 0: 8395: 100.00		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		101685 F8VWT9_HUMAN (1-4284): 0: 8395: 100.00		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		647414 HECD4_HUMAN (251-4284): 0: 7779: 99.03		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		927699 HECD4_HUMAN (251-4284): 0: 7779: 99.03		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		683849 HECD4_HUMAN (251-4284): 0: 7779: 99.03		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		982656 HECD4_HUMAN (251-4284): 0: 7779: 99.03		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		905299 HECD4_HUMAN (251-4284): 0: 7779: 99.03		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		125318 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		125169 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		125351 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		647267 WWP1_HUMAN (3745-4279): 2.28e-141: 470: 17.98		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Mm
		910302 NED4L_MOUSE (3770-4279): 1.17e-137: 462: 17.97		1433E_MOUSE (2-243): 1.31e-144: 406: 63.53
+	Hs
		647191 ITCH_HUMAN (3745-4279): 8.27e-141: 467: 18.22		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Mm
		1208289 NED4L_MOUSE (3770-4279): 1.17e-137: 462: 17.97		1433B_MOUSE (1-242): 2.84e-124: 354: 80.99
+	Mm
		935540 UBE3C_MOUSE (3700-4276): 9.92e-147: 491: 21.21		1433F_MOUSE (2-242): 4.62e-106: 308: 71.43
+	Hs
		125183 WWP2_HUMAN (3639-4279): 6.76e-146: 481: 16.52		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		684266 ITCH_HUMAN (3745-4279): 8.27e-141: 467: 18.22		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		904987 ITCH_HUMAN (3745-4279): 8.27e-141: 467: 18.22		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33