Protein: LST8
Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8)

Gene: LST8, MLST8
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q9BVC4

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol
GO:0006974 - DNA damage response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

839354

MTOR
Serine/threonine-protein kinase mTOR

33

14

Small-scale

0.993

High

1322642

RPTOR
Regulatory-associated protein of mTOR

17

20

Small-scale

0.983

High

1409781

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

5

3

Small-scale

0.906

High

1007246

TCPB
T-complex protein 1 subunit beta

4

20

High-throughput

0.903

High

1363689

TCPW
T-complex protein 1 subunit zeta-2

3

20

High-throughput

0.861

High

1407544

TCPH
T-complex protein 1 subunit eta

3

20

High-throughput

0.861

High

882131

TCPG
T-complex protein 1 subunit gamma

2

20

High-throughput

0.811

High

1246965

RICTR
Rapamycin-insensitive companion of mTOR

18

5

Small-scale

0.763

High

1347997

DPTOR
DEP domain-containing mTOR-interacting protein

2

1

Small-scale

0.737

High

1415158

CLMP
CXADR-like membrane protein

2

2

High-throughput

0.726

High

610866

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.691

High

773621

COPB2
Coatomer subunit beta'

1

16

High-throughput

0.691

High

821545

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.691

High

876152

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.691

High

899209

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.691

High

899560

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.691

High

1415155

PDCL3
Phosducin-like protein 3

1

7

High-throughput

0.691

High

1337796

DP13B
DCC-interacting protein 13-beta

2

12

High-throughput

0.686

High

1137498

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.665

High

638512

FPR1
fMet-Leu-Phe receptor

1

0

High-throughput

0.656

High

1147501

RHEB
GTP-binding protein Rheb

3

3

Small-scale

0.640

High

1121510

KEAP1
Kelch-like ECH-associated protein 1

2

2

Small-scale

0.620

High

182753

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.618

High

262295

SCN2B
Sodium channel regulatory subunit beta-2

1

3

High-throughput

0.618

High

333510

MPZL1
Myelin protein zero-like protein 1

1

3

High-throughput

0.618

High

1255344

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.618

High

1380130

FBXW7
F-box/WD repeat-containing protein 7

1

17

Small-scale

0.618

High

1415157

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.618

High

832567

ETV3
ETS translocation variant 3

2

9

High-throughput

0.611

High

1007601

PRAME
Melanoma antigen preferentially expressed in tumors

2

2

High-throughput

0.611

High

1091078

FOXF2
Forkhead box protein F2

2

6

High-throughput

0.611

High

1259472

TBA1A
Tubulin alpha-1A chain

2

16

High-throughput

0.611

High

1415152

THIC
Acetyl-CoA acetyltransferase, cytosolic

2

4

High-throughput

0.611

High

166404

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

2

1

High-throughput

0.601

High

334633

LYPA2
Acyl-protein thioesterase 2

2

0

High-throughput

0.585

High

841077

HELZ
Probable helicase with zinc finger domain

1

4

High-throughput

0.575

High

1415151

LST8
Target of rapamycin complex subunit LST8

1

15

High-throughput

0.575

High

1415162

SCN3B
Sodium channel regulatory subunit beta-3

1

3

High-throughput

0.575

High

1129979

MELK
Maternal embryonic leucine zipper kinase

2

2

High-throughput

0.558

High

1017560

PRR5
Proline-rich protein 5

1

2

Small-scale

0.554

High

845780

MUC18
Cell surface glycoprotein MUC18

1

2

Small-scale

0.553

High

50681

HACL2
2-hydroxyacyl-CoA lyase 2

2

1

High-throughput

0.549

High

927524

ATX1
Ataxin-1

1

3

High-throughput

0.541

High

443502

CDK1
Cyclin-dependent kinase 1

1

7

Small-scale

0.536

High

174395

ZN609
Zinc finger protein 609

1

8

High-throughput

0.536

High

347908

BAG3
BAG family molecular chaperone regulator 3

1

3

High-throughput

0.536

High

537823

HSP7C
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.536

High

600918

HSP76
Heat shock 70 kDa protein 6

1

10

High-throughput

0.536

High

913575

KIF11
Kinesin-like protein KIF11

1

4

High-throughput

0.536

High

931090

HSP72
Heat shock-related 70 kDa protein 2

1

10

High-throughput

0.536

High

997105

TBA4A
Tubulin alpha-4A chain

1

13

High-throughput

0.536

High

1007538

KRT85
Keratin, type II cuticular Hb5

1

5

High-throughput

0.536

High

1112452

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

3

Small-scale

0.536

High

1415156

SAV1
Protein salvador homolog 1

1

2

High-throughput

0.536

High

1415160

TF7L2
Transcription factor 7-like 2

1

18

High-throughput

0.536

High

1415165

BAG5
BAG family molecular chaperone regulator 5

1

3

High-throughput

0.536

High

1415167

CHIP
E3 ubiquitin-protein ligase CHIP

1

10

High-throughput

0.536

High

1415168

RUVB1
RuvB-like 1

1

9

High-throughput

0.536

High

1415170

PKHM1
Pleckstrin homology domain-containing family M member 1

1

1

Small-scale

0.536

High

1395283

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

1258176

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.517

High

1125635

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

13

Small-scale

0.515

High

1316060

TRM2A
tRNA

1

0

High-throughput

0.513

High

1383631

VOPP1
WW domain binding protein VOPP1

1

0

High-throughput

0.513

High

1415166

TPC2L
Trafficking protein particle complex subunit 2-like protein

1

0

High-throughput

0.513

High

1407843

ANM1
Protein arginine N-methyltransferase 1

1

5

High-throughput

0.508

High

668016

CDK2
Cyclin-dependent kinase 2

1

8

Small-scale

0.501

High

908167

KS6A3
Ribosomal protein S6 kinase alpha-3

1

3

Small-scale

0.501

High

1109566

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

1

Small-scale

0.501

High

1236095

PRR5L
Proline-rich protein 5-like

1

2

Small-scale

0.500

High

209103

CYB5B
Cytochrome b5 type B

1

1

High-throughput

0.489

High

1358257

ANR49
Ankyrin repeat domain-containing protein 49

1

5

High-throughput

0.489

High

1415172

NPTN
Neuroplastin

1

2

High-throughput

0.489

High

1357371

NAT14
Probable N-acetyltransferase 14

1

0

High-throughput

0.481

High

167968

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

10

Small-scale

0.479

High

173298

XPO1
Exportin-1

1

12

High-throughput

0.479

High

177938

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

9

Small-scale

0.479

High

279213

ULK1
Serine/threonine-protein kinase ULK1

1

5

Small-scale

0.479

High

889330

NUMB
Protein numb homolog

1

3

Small-scale

0.479

High

890882

TSC2
Tuberin

1

1

Small-scale

0.479

High

942853

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

8

High-throughput

0.479

High

965205

WDR5
WD repeat-containing protein 5

1

17

Small-scale

0.479

High

1067671

EP300
Histone acetyltransferase p300

1

11

High-throughput

0.479

High

1108104

SQSTM
Sequestosome-1

1

2

Small-scale

0.479

High

1232984

OTU7B
OTU domain-containing protein 7B

1

4

Small-scale

0.479

High

1245721

LARP1
La-related protein 1

1

8

High-throughput

0.479

High

1275964

SETX
Probable helicase senataxin

1

4

High-throughput

0.479

High

1340068

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

1

Small-scale

0.479

High

1358514

DC2I1
Cytoplasmic dynein 2 intermediate chain 1

1

16

High-throughput

0.479

High

1364983

TSC1
Hamartin

1

20

Small-scale

0.479

High

1404657

PFD5
Prefoldin subunit 5

1

8

High-throughput

0.479

High

1415153

XPO4
Exportin-4

1

13

High-throughput

0.479

High

1415159

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1415164

XPO7
Exportin-7

1

13

High-throughput

0.479

High

1415169

NUDC
Nuclear migration protein nudC

1

12

High-throughput

0.479

High

1415171

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

17

Small-scale

0.479

High

369742

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.464

High

1128819

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

1383397

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

1401073

XPO6
Exportin-6

1

0

High-throughput

0.458

High

1415154

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

Small-scale

0.458

High

1415161

S38A7
Sodium-coupled neutral amino acid transporter 7

1

0

Small-scale

0.458

High

516211

HS71B
Heat shock 70 kDa protein 1B

1

9

High-throughput

0.445

High

860345

RS9
Small ribosomal subunit protein uS4

1

4

Small-scale

0.445

High

1243657

S27A1
Long-chain fatty acid transport protein 1

1

2

High-throughput

0.445

High

66371

ARGFX
Arginine-fifty homeobox

1

3

High-throughput

0.437

High

291700

XRP2
Protein XRP2

1

0

High-throughput

0.426

High

683329

TNR5
Tumor necrosis factor receptor superfamily member 5

2

0

High-throughput

0.313

High

755511

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.279

Low

1329662

SERP2
Stress-associated endoplasmic reticulum protein 2

1

0

High-throughput

0.279

Low

1333442

XXLT1
Xyloside xylosyltransferase 1

1

0

High-throughput

0.279

Low

1415163

CC167
Coiled-coil domain-containing protein 167

1

0

High-throughput

0.279

Low

1251554

THADA
tRNA

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025