HitPredict

Interactor 1: H33 (P84243)
Histone H3.3
Gene: H3-3A

Interactor 2: SMC1A (Q14683)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
Gene: SMC1A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	36089195, 29044188
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046982 - protein heterodimerization activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 136 Hs			1 1233
+	Hs
		998318 H31_HUMAN (1-136): 3.09e-60: 183: 96.32		SMC1A_HUMAN (1-1233): 1.05e-127: 425: 100.00
+	Hs
		334037 H32_HUMAN (1-136): 5.34e-59: 180: 97.06		SMC2_HUMAN (3-1214): 4.82e-78: 283: 18.14
+	Sc
		864364 H3_YEAST (1-136): 3.63e-54: 168: 90.44		SMC3_YEAST (3-1215): 5.41e-79: 286: 18.20
+	Hs
		998954 H31_HUMAN (1-136): 3.09e-60: 183: 96.32		SMC3_HUMAN (3-1229): 5.78e-69: 255: 15.78
+	Hs
		1017306 H33_HUMAN (1-136): 1.13e-59: 182: 100.00		SMC3_HUMAN (3-1229): 5.78e-69: 255: 15.78
+	Sc
		808599 H3_YEAST (1-136): 3.63e-54: 168: 90.44		SMC2_YEAST (3-1213): 4.18e-73: 268: 16.75
+	Hs
		1258983 H32_HUMAN (1-136): 5.34e-59: 180: 97.06		SMC3_HUMAN (3-1229): 5.78e-69: 255: 15.78
+	Sc
		779277 CENPA_YEAST (41-134): 2.79e-31: 112: 67.01		SMC3_YEAST (3-1215): 5.41e-79: 286: 18.20