Protein: SMC3
Structural maintenance of chromosomes protein 3 (DA-box protein SMC3)

Gene: SMC3
Organism: Saccharomyces cerevisiae S288C
Interactions: 125
UniProt ID: P47037

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0003690 - double-stranded DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0007064 - mitotic sister chromatid cohesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

864383

SCC1
Sister chromatid cohesion protein 1

36

20

Small-scale

0.994

High

747737

SMC1
Structural maintenance of chromosomes protein 1

24

18

Small-scale

0.992

High

864369

SCC2
Sister chromatid cohesion protein 2

5

7

Small-scale

0.909

High

808594

SMC2
Structural maintenance of chromosomes protein 2

2

15

Small-scale

0.775

High

864388

SMC4
Structural maintenance of chromosomes protein 4

2

19

Small-scale

0.775

High

864355

SMC3
Structural maintenance of chromosomes protein 3

2

19

Small-scale

0.767

High

864384

REC8
Meiotic recombination protein REC8

2

1

Small-scale

0.754

High

826162

SCC3
Cohesin subunit SCC3

9

20

Small-scale

0.748

High

739982

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

4

5

Small-scale

0.699

High

864370

PDS5
Sister chromatid cohesion protein PDS5

5

20

Small-scale

0.699

High

850520

ECO1
N-acetyltransferase ECO1

3

1

Small-scale

0.655

High

382190

H4
Histone H4

3

6

High-throughput

0.643

High

779277

CENPA
Histone H3-like centromeric protein CSE4

3

11

Small-scale

0.640

High

864357

TCPQ
T-complex protein 1 subunit theta

2

1

High-throughput

0.621

High

864392

SMC6
Structural maintenance of chromosomes protein 6

1

16

High-throughput

0.618

High

545392

SSB1
Ribosome-associated molecular chaperone SSB1

2

11

High-throughput

0.601

High

755125

GCN1
eIF-2-alpha kinase activator GCN1

2

3

High-throughput

0.588

High

813291

FHP
Flavohemoprotein

2

3

High-throughput

0.588

High

864389

RUVB2
RuvB-like protein 2

2

2

High-throughput

0.588

High

864387

HOS1
Histone deacetylase HOS1

2

12

Small-scale

0.584

High

381157

H2B1
Histone H2B.1

2

20

High-throughput

0.571

High

864364

H3
Histone H3

2

11

High-throughput

0.571

High

864379

NOP12
Nucleolar protein 12

2

1

High-throughput

0.567

High

677688

MRC1
Mediator of replication checkpoint protein 1

1

1

Small-scale

0.561

High

864362

TOF1
Topoisomerase 1-associated factor 1

1

1

Small-scale

0.561

High

527045

HSP72
Heat shock protein SSA2

2

9

High-throughput

0.552

High

864365

NUM1
Nuclear migration protein NUM1

2

20

High-throughput

0.548

High

646459

RAD53
Serine/threonine-protein kinase RAD53

1

9

High-throughput

0.536

High

818503

SCC4
MAU2 chromatid cohesion factor homolog

1

1

High-throughput

0.515

High

365097

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.513

High

755261

NUF2
Kinetochore protein NUF2

1

6

High-throughput

0.508

High

864215

YJ41B
Transposon Ty4-J Gag-Pol polyprotein

1

2

High-throughput

0.508

High

864376

BRE1
E3 ubiquitin-protein ligase BRE1

1

17

High-throughput

0.508

High

864373

CSM3
Chromosome segregation in meiosis protein 3

1

1

Small-scale

0.501

High

734140

EF2
Elongation factor 2

1

6

High-throughput

0.489

High

864378

LUC7
Protein LUC7

1

0

High-throughput

0.486

High

722054

XPO1
Exportin-1

1

1

Small-scale

0.481

High

864393

RAD61
Protein RAD61

1

0

Small-scale

0.480

High

381554

H2B2
Histone H2B.2

1

20

High-throughput

0.479

High

392966

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.479

High

419453

H2A1
Histone H2A.1

1

5

High-throughput

0.479

High

419793

H2A2
Histone H2A.2

1

5

High-throughput

0.479

High

435194

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

594446

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

670876

SIS1
Protein SIS1

1

4

High-throughput

0.479

High

694581

SPT5
Transcription elongation factor SPT5

1

4

High-throughput

0.479

High

707500

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

709415

HRR25
Casein kinase I homolog HRR25

1

8

Small-scale

0.479

High

735050

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

743108

STH1
Nuclear protein STH1/NPS1

1

10

Small-scale

0.479

High

747924

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

763933

SPT10
Protein SPT10

1

2

High-throughput

0.479

High

792122

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.479

High

800662

KPR2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.479

High

815488

RSP5
E3 ubiquitin-protein ligase RSP5

1

5

Small-scale

0.479

High

822999

ATAD2
ATPase histone chaperone YTA7

1

3

Small-scale

0.479

High

864363

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.479

High

864375

CND3
Condensin complex subunit 3

1

10

Small-scale

0.479

High

864380

SGO1
Shugoshin

1

3

High-throughput

0.479

High

864382

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

864385

RIO1
Serine/threonine-protein kinase RIO1

1

5

High-throughput

0.479

High

864390

CMR1
DNA damage-binding protein CMR1

1

5

High-throughput

0.479

High

864212

YJ41A
Transposon Ty4-J Gag polyprotein

1

1

High-throughput

0.464

High

864374

KAR5
Nuclear fusion protein KAR5

1

1

High-throughput

0.464

High

738756

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

0

Small-scale

0.458

High

764107

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

805824

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.458

High

864356

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

394685

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

403561

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

4

High-throughput

0.445

High

453666

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

486234

TBA1
Tubulin alpha-1 chain

1

10

High-throughput

0.445

High

579653

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.445

High

592340

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.445

High

676122

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

741873

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.445

High

752444

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

805554

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

7

High-throughput

0.445

High

864368

HMO1
High mobility group protein 1

1

8

Small-scale

0.445

High

864391

H2AZ
Histone H2A.Z

1

5

High-throughput

0.445

High

405109

LEU3
3-isopropylmalate dehydrogenase

1

1

Small-scale

0.437

High

433719

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

503123

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

504291

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

512521

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

513091

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

674704

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

747450

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

753452

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

812443

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

864358

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

864367

BUL2
Ubiquitin ligase-binding protein BUL2

1

1

Small-scale

0.437

High

864377

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

864381

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

566512

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

High-throughput

0.426

High

684771

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

864359

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.426

High

433043

RL6B
Large ribosomal subunit protein eL6B

1

1

High-throughput

0.407

High

655482

RS3A2
Small ribosomal subunit protein eS1B

1

2

High-throughput

0.407

High

826446

DJP1
DnaJ-like protein 1

1

5

High-throughput

0.407

High

863627

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

864360

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

1

High-throughput

0.407

High

570062

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.279

Low

820912

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.279

Low

836767

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.279

Low

864361

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.279

Low

743871

YEF3
Uncharacterized protein YEL043W

1

0

High-throughput

0.265

Low

812239

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.265

Low

818522

PEA2
Protein PEA2

1

0

High-throughput

0.265

Low

813411

PO152
Nucleoporin POM152

1

0

High-throughput

0.251

Low

149842

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

511225

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

514708

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

561688

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.249

Low

689539

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

778407

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

790422

GLY1
Low specificity L-threonine aldolase

1

0

Small-scale

0.249

Low

802254

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

864366

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

864372

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

864371

GYL1
Probable GTPase-activating protein GYL1

1

0

High-throughput

0.238

Low

427340

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

569812

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.232

Low

864386

RL7B
Large ribosomal subunit protein uL30B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025