Protein: SMC2
Structural maintenance of chromosomes protein 2 (DA-box protein SMC2)

Gene: SMC2
Organism: Saccharomyces cerevisiae S288C
Interactions: 58
UniProt ID: P38989

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000217 - DNA secondary structure binding
GO:0000785 - chromatin
GO:0000793 - condensed chromosome
GO:0000796 - condensin complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

808614

SMC4
Structural maintenance of chromosomes protein 4

6

15

Small-scale

0.950

High

794841

CND2
Condensin complex subunit 2

5

8

Small-scale

0.916

High

808605

CND1
Condensin complex subunit 1

3

19

Small-scale

0.848

High

808594

SMC3
Structural maintenance of chromosomes protein 3

2

15

Small-scale

0.775

High

808606

CND3
Condensin complex subunit 3

7

10

Small-scale

0.742

High

808610

SGO1
Shugoshin

4

3

Small-scale

0.692

High

747722

SMC1
Structural maintenance of chromosomes protein 1

1

18

High-throughput

0.656

High

808603

SCC2
Sister chromatid cohesion protein 2

1

7

High-throughput

0.618

High

808612

SCC1
Sister chromatid cohesion protein 1

1

20

High-throughput

0.618

High

808616

SMC6
Structural maintenance of chromosomes protein 6

1

14

High-throughput

0.618

High

808592

NDC80
Kinetochore protein NDC80

1

12

Small-scale

0.573

High

523945

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.536

High

544871

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.536

High

808601

NU100
Nucleoporin NUP100/NSP100

2

2

Small-scale

0.533

High

808597

PAP2
Poly(A) RNA polymerase protein 2

1

1

Small-scale

0.515

High

808604

KAR5
Nuclear fusion protein KAR5

1

1

High-throughput

0.508

High

808607

BRE1
E3 ubiquitin-protein ligase BRE1

1

14

High-throughput

0.508

High

808611

SLK19
Kinetochore protein SLK19

1

14

High-throughput

0.508

High

486175

TBA1
Tubulin alpha-1 chain

1

10

Small-scale

0.501

High

592250

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.500

High

753022

SPC29
Spindle pole component 29

1

0

High-throughput

0.486

High

408324

GAL1
Galactokinase

1

0

High-throughput

0.479

High

808609

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.479

High

461024

MOD5
tRNA dimethylallyltransferase

1

1

Small-scale

0.479

High

694549

SPT5
Transcription elongation factor SPT5

1

4

High-throughput

0.479

High

707093

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

708735

TF3B
Transcription factor IIIB 70 kDa subunit

1

4

Small-scale

0.479

High

734981

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

Small-scale

0.479

High

745740

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

3

High-throughput

0.479

High

763886

SPT10
Protein SPT10

1

2

High-throughput

0.479

High

808593

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

808595

BIR1
Chromosomal passenger complex protein BIR1

1

1

Small-scale

0.479

High

808596

VID30
GID complex subunit 1

1

5

High-throughput

0.479

High

808598

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.479

High

808599

H3
Histone H3

1

9

High-throughput

0.479

High

808602

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

808613

RIO1
Serine/threonine-protein kinase RIO1

1

5

High-throughput

0.479

High

585622

STI1
Heat shock protein STI1

1

5

High-throughput

0.470

High

557709

SRS2
ATP-dependent DNA helicase SRS2

1

0

Small-scale

0.460

High

386707

TBB
Tubulin beta chain

1

5

Small-scale

0.457

High

808600

UBC7
Ubiquitin-conjugating enzyme E2 7

1

5

High-throughput

0.457

High

381102

H2B1
Histone H2B.1

1

15

High-throughput

0.445

High

392728

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.445

High

526694

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

590624

HSP26
Heat shock protein 26

1

2

High-throughput

0.445

High

670704

SIS1
Protein SIS1

1

4

High-throughput

0.445

High

675999

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

741580

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.445

High

742850

HSP79
Heat shock protein homolog SSE2

1

15

High-throughput

0.445

High

808589

CAJ1
Protein CAJ1

1

5

High-throughput

0.445

High

808590

HSP7E
Heat shock protein SSC3, mitochondrial

1

7

High-throughput

0.445

High

808591

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

808608

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

808588

TCPD
T-complex protein 1 subunit delta

1

0

High-throughput

0.426

High

808615

HSP42
Heat shock protein 42

1

2

High-throughput

0.407

High

801189

HIS9
Histidinol-phosphatase

1

0

High-throughput

0.269

Low

796860

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.249

Low

808617

EFG1P
rRNA-processing protein EFG1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025