HitPredict

Interactor 1: FBLN3 (Q12805)
EGF-containing fibulin-like extracellular matrix protein 1 (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3)
Gene: EFEMP1

Interactor 2: E4F1 (Q66K89)
Transcription factor E4F1 (EC 2.3.2.27) (E4F transcription factor 1) (Putative E3 ubiquitin-protein ligase E4F1) (RING-type E3 ubiquitin transferase E4F1) (Transcription factor E4F) (p120E4F) (p50E4F)
Gene: E4F1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 493 Hs			1 784
+	Hs
		1146279 LTBP4_HUMAN (16-293): 9.63e-18: 89: 19.00		E4F1_HUMAN (1-784): 0: 590: 100.00
+	Hs
		980401 NOTC2_HUMAN (5-386): 1.07e-16: 85.7: 10.63		E4F1_HUMAN (1-784): 0: 590: 100.00
+	Hs
		565090 NOTC2_HUMAN (5-386): 1.07e-16: 85.7: 10.63		ZNF7_HUMAN (194-615): 5.25e-119: 376: 24.48
+	Hs
		980435 NOTC2_HUMAN (5-386): 1.07e-16: 85.7: 10.63		ZN761_HUMAN (2-298): 3.8e-105: 341: 17.69
+	Hs
		477789 NOTC2_HUMAN (5-386): 1.07e-16: 85.7: 10.63		ZN888_HUMAN (24-345): 1.28e-91: 304: 16.72
+	Hs
		1016965 FBLN3_HUMAN (1-493): 4.37e-74: 243: 100.00		GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00
+	Hs
		980570 NOTC2_HUMAN (5-386): 1.07e-16: 85.7: 10.63		ZN107_HUMAN (2-172): 4.29e-52: 196: 9.44
+	Hs
		980500 NOTC2_HUMAN (5-386): 1.07e-16: 85.7: 10.63		ZN594_HUMAN (3-125): 9.43e-30: 128: 10.00
+	Hs
		957284 FBLN2_HUMAN (29-449): 5.23e-13: 73.7: 19.00		ZN594_HUMAN (3-125): 9.43e-30: 128: 10.00
+	Hs
		980558 NOTC2_HUMAN (5-386): 1.07e-16: 85.7: 10.63		RBAK_HUMAN (192-269): 2.29e-13: 75.9: 42.31
+	Hs
		254234 MEGF6_HUMAN (173-347): 3.34e-19: 93.2: 35.91		GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00
+	Hs
		1138062 LTBP4_HUMAN (16-293): 9.63e-18: 89: 19.00		GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00
+	Hs
		980498 NOTC2_HUMAN (5-386): 1.07e-16: 85.7: 10.63		ZN419_HUMAN (192-271): 1.48e-10: 66.2: 41.25
+	Hs
		980560 NOTC2_HUMAN (5-386): 1.07e-16: 85.7: 10.63		ZN624_HUMAN (2-55): 1.11e-09: 64: 12.96
+	Hs
		980396 NOTC2_HUMAN (5-386): 1.07e-16: 85.7: 10.63		ZN766_HUMAN (194-268): 2.82e-09: 62.4: 41.33
+	Hs
		328061 FBLN4_HUMAN (2-224): 1.75e-12: 71: 18.22		RBAK_HUMAN (192-269): 2.29e-13: 75.9: 42.31
+	Hs
		980511 NOTC2_HUMAN (5-386): 1.07e-16: 85.7: 10.63		ZN317_HUMAN (192-268): 9.82e-09: 60.8: 36.36
+	Hs
		612865 FBLN1_HUMAN (256-434): 1.35e-12: 72.1: 25.00		GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00
+	Hs
		328002 FBLN4_HUMAN (2-224): 1.75e-12: 71: 18.22		GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00
+	Hs
		1138087 FBLN5_HUMAN (2-227): 4.17e-11: 66.8: 18.34		GFI1B_HUMAN (192-266): 2.9e-10: 64.3: 36.00