Protein: PPIL2
RING-type E3 ubiquitin-protein ligase PPIL2 (EC 2.3.2.27) (CYC4) (Cyclophilin-60) (Cyclophilin-like protein Cyp-60) (Cyp60) (hCyP-60) (Probable inactive peptidyl-prolyl cis-trans isomerase-like 2) (PPIase) (Rotamase PPIL2)

Gene: PPIL2
Organism: Homo sapiens
Interactions: 81
UniProt ID: Q13356

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005796 - Golgi lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

276684

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

3

7

High-throughput

0.861

High

1103058

ZN830
Zinc finger protein 830

5

0

Small-scale

0.692

High

1103047

MK14
Mitogen-activated protein kinase 14

3

2

High-throughput

0.667

High

1103040

PPIL2
RING-type E3 ubiquitin-protein ligase PPIL2

1

6

Small-scale

0.621

High

1103050

PRP8
Pre-mRNA-processing-splicing factor 8

1

6

High-throughput

0.618

High

1103076

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

9

High-throughput

0.618

High

1049256

1433F
14-3-3 protein eta

2

10

High-throughput

0.601

High

1103046

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.586

High

371943

MYC
Myc proto-oncogene protein

2

8

High-throughput

0.584

High

385712

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

7

High-throughput

0.584

High

980742

H2B1C
Histone H2B type 1-C/E/F/G/I

2

1

High-throughput

0.584

High

1103043

TNIP1
TNFAIP3-interacting protein 1

2

6

High-throughput

0.584

High

919932

PLK1
Serine/threonine-protein kinase PLK1

1

6

Small-scale

0.561

High

349983

SNAI1
Zinc finger protein SNAI1

1

0

Small-scale

0.549

High

783260

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.549

High

574249

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

5

High-throughput

0.536

High

1036647

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

3

High-throughput

0.536

High

1103041

CUL4B
Cullin-4B

1

1

High-throughput

0.536

High

1103049

DCA10
DDB1- and CUL4-associated factor 10

1

4

High-throughput

0.536

High

1103051

KLC3
Kinesin light chain 3

1

2

High-throughput

0.536

High

1103065

KLC2
Kinesin light chain 2

1

2

High-throughput

0.536

High

1103072

PIM2
Serine/threonine-protein kinase pim-2

1

1

High-throughput

0.536

High

1103077

BAIP2
BAR/IMD domain-containing adapter protein 2

1

1

High-throughput

0.536

High

886823

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.527

High

593357

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.513

High

1103067

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

422053

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

1103068

KANL2
KAT8 regulatory NSL complex subunit 2

1

0

High-throughput

0.493

High

1103055

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.486

High

190896

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

4

High-throughput

0.479

High

345762

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

411869

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

413763

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

461439

HS90A
Heat shock protein HSP 90-alpha

1

3

Small-scale

0.479

High

558100

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

613022

EGR1
Early growth response protein 1

1

1

Small-scale

0.479

High

634426

LMNB1
Lamin-B1

1

7

High-throughput

0.479

High

714087

PML
Protein PML

1

4

High-throughput

0.479

High

774329

BASI
Basigin

1

1

Small-scale

0.479

High

776066

SOX5
Transcription factor SOX-5

1

2

High-throughput

0.479

High

776186

SOX6
Transcription factor SOX-6

1

5

High-throughput

0.479

High

830678

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

881517

CDK8
Cyclin-dependent kinase 8

1

2

High-throughput

0.479

High

883235

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.479

High

883530

CENPA
Histone H3-like centromeric protein A

1

6

High-throughput

0.479

High

904672

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

998281

H31
Histone H3.1

1

6

High-throughput

0.479

High

1016829

H33
Histone H3.3

1

6

High-throughput

0.479

High

1047966

TLE3
Transducin-like enhancer protein 3

1

4

High-throughput

0.479

High

1067275

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1097269

CBX3
Chromobox protein homolog 3

1

3

High-throughput

0.479

High

1103042

DHX8
ATP-dependent RNA helicase DHX8

1

2

High-throughput

0.479

High

1103044

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

1103045

RBBP5
Retinoblastoma-binding protein 5

1

4

High-throughput

0.479

High

1103054

SLX4
Structure-specific endonuclease subunit SLX4

1

4

High-throughput

0.479

High

1103056

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

6

High-throughput

0.479

High

1103059

CDC5L
Cell division cycle 5-like protein

1

5

High-throughput

0.479

High

1103061

DDX23
Probable ATP-dependent RNA helicase DDX23

1

2

High-throughput

0.479

High

1103063

ACE2
Angiotensin-converting enzyme 2

1

1

Small-scale

0.479

High

1103064

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

1103066

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1103071

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1103073

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1103078

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

799874

COIL
Coilin

1

0

High-throughput

0.458

High

984743

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

1103052

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1103060

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.458

High

1103062

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1103070

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.458

High

1103074

XPO7
Exportin-7

1

0

High-throughput

0.458

High

690974

1433T
14-3-3 protein theta

1

10

High-throughput

0.445

High

729803

1433B
14-3-3 protein beta/alpha

1

10

High-throughput

0.445

High

1103053

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

2

High-throughput

0.445

High

1064981

FGL1
Fibrinogen-like protein 1

4

0

High-throughput

0.360

High

1103075

NAGK
N-acetyl-D-glucosamine kinase

2

0

High-throughput

0.328

High

1103048

VP26B
Vacuolar protein sorting-associated protein 26B

1

0

High-throughput

0.279

Low

1103069

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.279

Low

1103057

SNX27
Sorting nexin-27

1

0

High-throughput

0.249

Low

733843

CDD
Cytidine deaminase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025