Protein: PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1 (PPIase) (EC 5.2.1.8) (Rotamase PPIL1)

Gene: PPIL1
Organism: Homo sapiens
Interactions: 115
UniProt ID: Q9Y3C6

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000413 - protein peptidyl-prolyl isomerization
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1160353

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

2

High-throughput

0.831

High

1127274

RBM39
RNA-binding protein 39

2

3

High-throughput

0.789

High

1111383

SNW1
SNW domain-containing protein 1

7

3

Small-scale

0.754

High

1241865

PRP8
Pre-mRNA-processing-splicing factor 8

2

5

High-throughput

0.754

High

250907

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.691

High

478267

SNRPA
U1 small nuclear ribonucleoprotein A

1

3

High-throughput

0.691

High

685786

U2AF2
Splicing factor U2AF 65 kDa subunit

1

6

High-throughput

0.691

High

775388

FUS
RNA-binding protein FUS

1

5

High-throughput

0.691

High

1451089

RBM22
Pre-mRNA-splicing factor RBM22

1

1

High-throughput

0.691

High

1461667

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

1

High-throughput

0.691

High

1462373

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

6

High-throughput

0.691

High

485532

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.656

High

1413429

RBM42
RNA-binding protein 42

1

5

High-throughput

0.656

High

351367

SYF2
Pre-mRNA-splicing factor SYF2

1

0

High-throughput

0.656

High

1453666

CWC15
Spliceosome-associated protein CWC15 homolog

1

0

High-throughput

0.656

High

587267

ITF2
Transcription factor 4

3

0

High-throughput

0.646

High

1412059

WDR83
WD repeat domain-containing protein 83

2

4

High-throughput

0.644

High

1033325

EWS
RNA-binding protein EWS

1

4

High-throughput

0.618

High

1404534

CDC5L
Cell division cycle 5-like protein

2

4

High-throughput

0.611

High

895825

LHX2
LIM/homeobox protein Lhx2

2

1

High-throughput

0.606

High

1008006

PO6F2
POU domain, class 6, transcription factor 2

2

1

High-throughput

0.606

High

1368840

N42L2
NEDD4-binding protein 2-like 2

2

1

High-throughput

0.606

High

1491035

DEOC
Deoxyribose-phosphate aldolase

2

0

High-throughput

0.602

High

373577

MYC
Myc proto-oncogene protein

2

7

High-throughput

0.584

High

1312870

GPAM1
GPALPP motifs-containing protein 1

2

2

High-throughput

0.574

High

1459110

RIM3A
RIMS-binding protein 3A

1

4

High-throughput

0.573

High

1209823

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

5

High-throughput

0.571

High

1462037

COHA1
Collagen alpha-1(XVII) chain

2

1

High-throughput

0.553

High

1006816

SRPK2
SRSF protein kinase 2

1

4

High-throughput

0.550

High

1402650

SRPK1
SRSF protein kinase 1

1

4

High-throughput

0.550

High

245175

AQR
RNA helicase aquarius

1

1

High-throughput

0.536

High

251052

PRP17
Pre-mRNA-processing factor 17

1

4

High-throughput

0.536

High

480361

RU1C
U1 small nuclear ribonucleoprotein C

1

2

High-throughput

0.536

High

542294

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

574528

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

3

High-throughput

0.536

High

833569

BUD31
Protein BUD31 homolog

1

3

High-throughput

0.536

High

854398

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.536

High

974089

RUXF
Small nuclear ribonucleoprotein F

1

7

High-throughput

0.536

High

1065509

SSRP1
FACT complex subunit SSRP1

1

4

High-throughput

0.536

High

1149235

SF3A1
Splicing factor 3A subunit 1

1

2

High-throughput

0.536

High

1180523

C19L2
CWF19-like protein 2

1

1

High-throughput

0.536

High

1229518

C19L1
CWF19-like protein 1

1

1

High-throughput

0.536

High

1411677

GPTC1
G patch domain-containing protein 1

1

1

High-throughput

0.536

High

1419987

CRNL1
Crooked neck-like protein 1

1

4

High-throughput

0.536

High

1434798

DHX35
Probable ATP-dependent RNA helicase DHX35

1

1

High-throughput

0.536

High

1439444

SYF1
Pre-mRNA-splicing factor SYF1

1

4

High-throughput

0.536

High

1458259

TFP11
Tuftelin-interacting protein 11

1

1

High-throughput

0.536

High

619964

VCAM1
Vascular cell adhesion protein 1

2

2

High-throughput

0.521

High

286122

SF3B1
Splicing factor 3B subunit 1

1

0

High-throughput

0.513

High

298124

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.513

High

594867

GCFC2
Intron Large complex component GCFC2

1

0

High-throughput

0.513

High

1356588

CCD12
Coiled-coil domain-containing protein 12

1

0

High-throughput

0.513

High

1389634

SAAL1
Protein SAAL1

1

0

High-throughput

0.513

High

1325778

LNX2
Ligand of Numb protein X 2

1

5

High-throughput

0.512

High

1091799

PP1R8
Nuclear inhibitor of protein phosphatase 1

1

1

High-throughput

0.508

High

1410412

MEP50
Methylosome protein WDR77

1

3

High-throughput

0.508

High

1414366

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

1

High-throughput

0.508

High

1117229

THOC5
THO complex subunit 5

1

0

High-throughput

0.486

High

1148093

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.486

High

332191

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

0

High-throughput

0.480

High

129586

MEN1
Menin

1

2

High-throughput

0.479

High

223442

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

386392

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

4

High-throughput

0.479

High

401745

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

406833

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.479

High

590099

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

696939

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

766041

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.479

High

769584

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

831691

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

854964

RECQ1
ATP-dependent DNA helicase Q1

1

2

High-throughput

0.479

High

879653

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

887369

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.479

High

920389

PLK1
Serine/threonine-protein kinase PLK1

1

6

High-throughput

0.479

High

937993

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.479

High

971336

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

998989

H31
Histone H3.1

1

3

High-throughput

0.479

High

1096872

RFA4
Replication protein A 30 kDa subunit

1

4

High-throughput

0.479

High

1141087

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1277010

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1314739

SRRM1
Serine/arginine repetitive matrix protein 1

1

1

High-throughput

0.479

High

1347002

SNIP1
Smad nuclear-interacting protein 1

1

1

High-throughput

0.479

High

1352857

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1367661

ESR2
Estrogen receptor beta

1

14

High-throughput

0.479

High

1370488

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.479

High

1416969

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.479

High

1417536

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

1459413

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1461930

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

1462665

SRRM2
Serine/arginine repetitive matrix protein 2

1

1

High-throughput

0.479

High

1491046

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

6

High-throughput

0.479

High

1491181

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.479

High

1491182

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

6

High-throughput

0.479

High

320174

UFL1
E3 UFM1-protein ligase 1

1

0

Small-scale

0.460

High

134924

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

1211574

ZN362
Zinc finger protein 362

1

0

High-throughput

0.458

High

1235581

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.458

High

1405580

TBX5
T-box transcription factor TBX5

1

0

High-throughput

0.458

High

344377

PTBP3
Polypyrimidine tract-binding protein 3

1

1

High-throughput

0.445

High

530641

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

1203303

ODFP2
Outer dense fiber protein 2

1

1

High-throughput

0.445

High

294567

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.437

High

346543

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.437

High

389580

FINC
Fibronectin

1

2

High-throughput

0.437

High

565497

ITA4
Integrin alpha-4

1

1

High-throughput

0.437

High

900610

GRAM
Granzyme M

1

2

High-throughput

0.437

High

1256214

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1290850

ZCH18
Zinc finger CCCH domain-containing protein 18

1

5

High-throughput

0.437

High

66910

SPDE4
Speedy protein E4

2

0

High-throughput

0.316

High

506776

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

1213864

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.316

High

1386915

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.316

High

1390235

SAT2
Thialysine N-epsilon-acetyltransferase

1

0

High-throughput

0.279

Low

1316031

PRR22
Proline-rich protein 22

1

0

High-throughput

0.251

Low

1386809

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025