HitPredict

Interactor 1: MERTK (Q12866)
Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)
Gene: MERTK

Interactor 2: FBX2 (Q9UK22)
F-box only protein 2
Gene: FBXO2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 999 Hs			1 296
+	Hs
		872501 EPHA5_HUMAN (29-967): 0: 639: 17.50		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		872590 EPHB4_HUMAN (48-980): 0: 582: 17.29		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		600701 EPHA1_HUMAN (2-965): 2.9e-165: 512: 18.03		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		435799 IGF1R_HUMAN (318-859): 5.21e-138: 449: 28.34		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		411522 INSR_HUMAN (326-864): 3.29e-136: 445: 29.84		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		435773 IGF1R_HUMAN (318-859): 5.21e-138: 449: 28.34		FBX6_HUMAN (40-296): 2.4e-133: 381: 49.81
+	Hs
		441579 MET_HUMAN (568-901): 1.17e-67: 249: 40.88		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		441570 MET_HUMAN (568-901): 1.17e-67: 249: 40.88		FBX6_HUMAN (40-296): 2.4e-133: 381: 49.81
+	Hs
		601610 FGFR2_HUMAN (1-295): 4.46e-53: 201: 14.21		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		981927 RON_HUMAN (535-861): 1.17e-59: 225: 37.95		FBX6_HUMAN (40-296): 2.4e-133: 381: 49.81
+	Hs
		609600 FGFR3_HUMAN (2-295): 1.33e-41: 166: 13.41		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00
+	Hs
		609560 FGFR3_HUMAN (2-295): 1.33e-41: 166: 13.41		FBX6_HUMAN (40-296): 2.4e-133: 381: 49.81
+	Hs
		674561 UFO_HUMAN (16-405): 5.47e-13: 75.2: 10.75		FBX2_HUMAN (1-296): 5.13e-147: 416: 100.00