Protein: AGO4
Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4)

Gene: AGO4
Organism: Homo sapiens
Interactions: 127
UniProt ID: Q9HCK5

Gene Ontology (top 5):
GO:0000932 - P-body
GO:0003725 - double-stranded RNA binding
GO:0003727 - single-stranded RNA binding
GO:0004521 - RNA endonuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1437064

AGO3
Protein argonaute-3

3

12

High-throughput

0.861

High

1439216

DICER
Endoribonuclease Dicer

2

20

Small-scale

0.789

High

1336852

TNR6A
Trinucleotide repeat-containing gene 6A protein

5

17

Small-scale

0.723

High

1150700

TRBP2
RISC-loading complex subunit TARBP2

1

15

High-throughput

0.691

High

1439212

AGO2
Protein argonaute-2

1

12

High-throughput

0.691

High

1439215

TNR6B
Trinucleotide repeat-containing gene 6B protein

3

17

Small-scale

0.678

High

1439099

TNR6C
Trinucleotide repeat-containing gene 6C protein

2

20

Small-scale

0.646

High

623550

RO52
E3 ubiquitin-protein ligase TRIM21

2

3

Small-scale

0.639

High

1144175

TEBP
Prostaglandin E synthase 3

2

10

High-throughput

0.628

High

535560

BIP
Endoplasmic reticulum chaperone BiP

2

3

Small-scale

0.619

High

423224

A4
Amyloid-beta precursor protein

2

1

High-throughput

0.602

High

189285

IPO8
Importin-8

1

5

High-throughput

0.586

High

1439213

AGO1
Protein argonaute-1

1

12

High-throughput

0.575

High

1308405

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

2

6

High-throughput

0.574

High

67508

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

1

High-throughput

0.536

High

162705

ANM5
Protein arginine N-methyltransferase 5

1

3

High-throughput

0.536

High

225337

HTSF1
17S U2 SnRNP complex component HTATSF1

1

13

High-throughput

0.536

High

259124

DNJA2
DnaJ homolog subfamily A member 2

1

8

High-throughput

0.536

High

425045

ADT2
ADP/ATP translocase 2

1

8

High-throughput

0.536

High

457721

TBB5
Tubulin beta chain

1

7

High-throughput

0.536

High

461951

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.536

High

462652

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

5

High-throughput

0.536

High

468825

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.536

High

537943

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.536

High

539420

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

4

High-throughput

0.536

High

612311

ARF4
ADP-ribosylation factor 4

1

1

High-throughput

0.536

High

658778

JAK1
Tyrosine-protein kinase JAK1

1

2

High-throughput

0.536

High

660735

IF4B
Eukaryotic translation initiation factor 4B

1

13

High-throughput

0.536

High

684400

DDX6
Probable ATP-dependent RNA helicase DDX6

1

18

High-throughput

0.536

High

688162

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.536

High

727979

DNJA1
DnaJ homolog subfamily A member 1

1

8

High-throughput

0.536

High

784736

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

2

High-throughput

0.536

High

842548

RL35
Large ribosomal subunit protein uL29

1

2

High-throughput

0.536

High

859078

RL27A
Large ribosomal subunit protein uL15

1

4

High-throughput

0.536

High

860367

RS9
Small ribosomal subunit protein uS4

1

3

High-throughput

0.536

High

860616

RS5
Small ribosomal subunit protein uS7

1

4

High-throughput

0.536

High

876183

TCPE
T-complex protein 1 subunit epsilon

1

4

High-throughput

0.536

High

882902

EFTU
Elongation factor Tu, mitochondrial

1

4

High-throughput

0.536

High

895076

EMD
Emerin

1

1

High-throughput

0.536

High

916353

TXTP
Tricarboxylate transport protein, mitochondrial

1

9

High-throughput

0.536

High

953117

ACTB
Actin, cytoplasmic 1

1

2

High-throughput

0.536

High

961410

RL27
Large ribosomal subunit protein eL27

1

2

High-throughput

0.536

High

972969

RS18
Small ribosomal subunit protein uS13

1

4

High-throughput

0.536

High

981974

RL23
Large ribosomal subunit protein uL14

1

5

High-throughput

0.536

High

983210

RS26
Small ribosomal subunit protein eS26

1

2

High-throughput

0.536

High

985899

RL11
Large ribosomal subunit protein uL5

1

4

High-throughput

0.536

High

992086

RL38
Large ribosomal subunit protein eL38

1

3

High-throughput

0.536

High

994813

YBOX1
Y-box-binding protein 1

1

8

High-throughput

0.536

High

997524

TBB4B
Tubulin beta-4B chain

1

7

High-throughput

0.536

High

1013875

RL24
Large ribosomal subunit protein eL24

1

3

High-throughput

0.536

High

1024471

S25A3
Solute carrier family 25 member 3

1

12

High-throughput

0.536

High

1057268

PRDX1
Peroxiredoxin-1

1

1

High-throughput

0.536

High

1102105

PABP4
Polyadenylate-binding protein 4

1

9

High-throughput

0.536

High

1105419

SF3B2
Splicing factor 3B subunit 2

1

2

High-throughput

0.536

High

1106084

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

15

High-throughput

0.536

High

1135114

CUL7
Cullin-7

1

3

High-throughput

0.536

High

1137164

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

14

High-throughput

0.536

High

1257950

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

1

High-throughput

0.536

High

1310793

CUL9
Cullin-9

1

4

High-throughput

0.536

High

1330571

PAF1
RNA polymerase II-associated factor 1 homolog

1

1

High-throughput

0.536

High

1339589

KBTB8
Kelch repeat and BTB domain-containing protein 8

1

2

High-throughput

0.536

High

1357764

TRI41
E3 ubiquitin-protein ligase TRIM41

1

3

High-throughput

0.536

High

1388744

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

High-throughput

0.536

High

1398224

ZFP42
Zinc finger protein 42 homolog

1

2

High-throughput

0.536

High

1404061

MYCBP
c-Myc-binding protein

1

1

High-throughput

0.536

High

1409646

DHB14
L-fucose dehydrogenase

1

1

High-throughput

0.536

High

1410378

MEP50
Methylosome protein WDR77

1

7

High-throughput

0.536

High

1434912

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

1

4

High-throughput

0.536

High

1439203

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

14

High-throughput

0.536

High

1439206

DJB11
DnaJ homolog subfamily B member 11

1

8

High-throughput

0.536

High

1439207

DIC
Mitochondrial dicarboxylate carrier

1

8

High-throughput

0.536

High

532985

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.515

High

340680

STABP
STAM-binding protein

1

0

High-throughput

0.513

High

351174

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.513

High

540095

BCR
Breakpoint cluster region protein

1

0

High-throughput

0.513

High

903643

GALK1
Galactokinase

1

0

High-throughput

0.513

High

1042597

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

1

0

High-throughput

0.513

High

1048708

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.513

High

1199838

AGK
Acylglycerol kinase, mitochondrial

1

0

High-throughput

0.513

High

1234712

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

1

0

High-throughput

0.513

High

1357912

LEO1
RNA polymerase-associated protein LEO1

1

0

High-throughput

0.513

High

1439210

CTNA3
Catenin alpha-3

1

0

High-throughput

0.513

High

1439214

TBX20
T-box transcription factor TBX20

1

0

High-throughput

0.513

High

1239173

PR40B
Pre-mRNA-processing factor 40 homolog B

1

1

High-throughput

0.489

High

1243861

CTR9
RNA polymerase-associated protein CTR9 homolog

1

1

High-throughput

0.489

High

1436755

GHC1
Mitochondrial glutamate carrier 1

1

9

High-throughput

0.489

High

1439211

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

8

High-throughput

0.489

High

66053

WTIP
Wilms tumor protein 1-interacting protein

1

7

Small-scale

0.479

High

180934

TIF1A
Transcription intermediary factor 1-alpha

1

14

Small-scale

0.479

High

331339

KI20A
Kinesin-like protein KIF20A

1

9

High-throughput

0.479

High

409092

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

4

High-throughput

0.479

High

692140

MARK3
MAP/microtubule affinity-regulating kinase 3

1

11

High-throughput

0.479

High

1140894

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1252395

MEX3B
RNA-binding protein MEX3B

1

6

High-throughput

0.479

High

1270531

MARK2
Serine/threonine-protein kinase MARK2

1

11

High-throughput

0.479

High

1439201

RNF12
E3 ubiquitin-protein ligase RLIM

1

4

High-throughput

0.479

High

1439204

MARK1
Serine/threonine-protein kinase MARK1

1

11

High-throughput

0.479

High

1439208

LIMD1
LIM domain-containing protein 1

1

7

Small-scale

0.479

High

1439200

MYO5C
Unconventional myosin-Vc

1

0

High-throughput

0.458

High

419216

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.445

High

550476

PABP1
Polyadenylate-binding protein 1

1

9

High-throughput

0.445

High

716979

RL12
Large ribosomal subunit protein uL11

1

2

High-throughput

0.445

High

942900

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

6

High-throughput

0.445

High

959976

RS3A
Small ribosomal subunit protein eS1

1

3

High-throughput

0.445

High

986228

RL8
Large ribosomal subunit protein uL2

1

2

High-throughput

0.445

High

996348

EF1A1
Elongation factor 1-alpha 1

1

3

High-throughput

0.445

High

1023177

RBM10
RNA-binding protein 10

1

13

High-throughput

0.445

High

1202011

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.445

High

1202077

HS905
Putative heat shock protein HSP 90-alpha A5

1

20

High-throughput

0.445

High

1259519

TBA1A
Tubulin alpha-1A chain

1

6

High-throughput

0.445

High

1401876

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1439202

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

1

High-throughput

0.445

High

162282

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.426

High

673965

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.426

High

974671

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.426

High

983061

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.426

High

665942

IBP6
Insulin-like growth factor-binding protein 6

1

0

High-throughput

0.279

Low

871489

LEPR
Leptin receptor

1

0

High-throughput

0.279

Low

940692

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

0

High-throughput

0.279

Low

1206251

PREP
Presequence protease, mitochondrial

1

0

High-throughput

0.279

Low

1228330

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.279

Low

1340421

RASF8
Ras association domain-containing protein 8

1

0

High-throughput

0.279

Low

1393504

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.279

Low

1439205

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.279

Low

1439209

PCS1N
ProSAAS

1

0

High-throughput

0.279

Low

1439217

PPME1
Protein phosphatase methylesterase 1

1

0

High-throughput

0.279

Low

1439199

RS10L
Putative ribosomal protein eS10-like

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025