Protein: PAF1
RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2)

Gene: PAF1
Organism: Homo sapiens
Interactions: 186
UniProt ID: Q8N7H5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000993 - RNA polymerase II complex binding
GO:0001650 - fibrillar center
GO:0001711 - endodermal cell fate commitment
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1240657

CDC73
Parafibromin

16

3

Small-scale

0.985

High

1330543

LEO1
RNA polymerase-associated protein LEO1

15

10

Small-scale

0.984

High

1243826

CTR9
RNA polymerase-associated protein CTR9 homolog

12

6

Small-scale

0.981

High

1244354

SKI3
Superkiller complex protein 3

2

5

Small-scale

0.789

High

1330562

SKI8
Superkiller complex protein 8

7

5

Small-scale

0.745

High

667370

RPB1
DNA-directed RNA polymerase II subunit RPB1

5

2

Small-scale

0.711

High

1330547

RTF1
RNA polymerase-associated protein RTF1 homolog

5

2

Small-scale

0.709

High

654658

TCEA1
Transcription elongation factor A protein 1

3

1

Small-scale

0.676

High

941810

ARL4C
ADP-ribosylation factor-like protein 4C

3

0

High-throughput

0.634

High

1314019

YAF2
YY1-associated factor 2

3

0

High-throughput

0.634

High

130544

SPT5H
Transcription elongation factor SPT5

2

2

High-throughput

0.628

High

131069

TULP2
Tubby-related protein 2

2

1

High-throughput

0.628

High

1040739

ENL
Protein ENL

2

2

Small-scale

0.624

High

900419

FXR2
RNA-binding protein FXR2

2

0

High-throughput

0.613

High

1217883

BRE1A
E3 ubiquitin-protein ligase BRE1A

2

2

Small-scale

0.611

High

1314310

SLX4
Structure-specific endonuclease subunit SLX4

2

2

High-throughput

0.601

High

1041558

KMT2A
Histone-lysine N-methyltransferase 2A

1

1

Small-scale

0.597

High

897902

CDK9
Cyclin-dependent kinase 9

2

2

Small-scale

0.594

High

775201

FUS
RNA-binding protein FUS

2

0

High-throughput

0.585

High

260182

BRD4
Bromodomain-containing protein 4

2

2

Small-scale

0.584

High

302896

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

2

3

High-throughput

0.584

High

372584

MYC
Myc proto-oncogene protein

2

2

High-throughput

0.584

High

487535

PARP1
Poly [ADP-ribose] polymerase 1

2

3

High-throughput

0.584

High

1053701

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

1

Small-scale

0.584

High

1330584

SP16H
FACT complex subunit SPT16

2

1

Small-scale

0.584

High

959001

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

0

Small-scale

0.576

High

1330546

MYLIP
E3 ubiquitin-protein ligase MYLIP

2

1

High-throughput

0.574

High

908215

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

1

High-throughput

0.571

High

909348

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

0

Small-scale

0.561

High

596236

H12
Histone H1.2

1

1

Small-scale

0.561

High

998546

H31
Histone H3.1

1

2

Small-scale

0.561

High

242288

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

415725

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.558

High

1102346

GRB10
Growth factor receptor-bound protein 10

2

0

High-throughput

0.547

High

279422

TULP3
Tubby-related protein 3

1

1

High-throughput

0.541

High

445968

ENOA
Alpha-enolase

1

1

High-throughput

0.541

High

360040

NB5R3
NADH-cytochrome b5 reductase 3

1

1

High-throughput

0.536

High

431190

LA
Lupus La protein

1

1

High-throughput

0.536

High

449755

H2B1J
Histone H2B type 1-J

1

2

High-throughput

0.536

High

481333

HMGB1
High mobility group protein B1

1

5

High-throughput

0.536

High

542118

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

547169

PYC
Pyruvate carboxylase, mitochondrial

1

4

High-throughput

0.536

High

625494

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.536

High

766693

PHB1
Prohibitin 1

1

2

High-throughput

0.536

High

872533

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.536

High

1006919

KC1G2
Casein kinase I isoform gamma-2

1

1

High-throughput

0.536

High

1065305

SSRP1
FACT complex subunit SSRP1

1

4

High-throughput

0.536

High

1094213

ACACA
Acetyl-CoA carboxylase 1

1

4

High-throughput

0.536

High

1163059

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

1330553

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1330564

SENP3
Sentrin-specific protease 3

1

2

High-throughput

0.536

High

1330571

AGO4
Protein argonaute-4

1

1

High-throughput

0.536

High

1330572

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

5

High-throughput

0.536

High

1330583

NGN3
Neurogenin-3

1

1

High-throughput

0.536

High

887027

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.527

High

130166

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.513

High

244265

NUAK1
NUAK family SNF1-like kinase 1

1

0

High-throughput

0.513

High

478120

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

480227

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

574375

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

640956

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

High-throughput

0.513

High

973979

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

976115

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.513

High

979062

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.513

High

1092592

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.513

High

1160209

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

1204374

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

1280989

PXK
PX domain-containing protein kinase-like protein

1

0

High-throughput

0.513

High

1330541

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1330544

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

0

High-throughput

0.513

High

1330559

SERC2
Serine incorporator 2

1

0

High-throughput

0.513

High

1330567

CB39L
Calcium-binding protein 39-like

1

0

High-throughput

0.513

High

964372

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

1042892

ERCC6
DNA excision repair protein ERCC-6

1

8

High-throughput

0.501

High

1328602

MS3L1
MSL complex subunit 3

1

1

Small-scale

0.501

High

251621

CCNT1
Cyclin-T1

1

1

Small-scale

0.500

High

297014

CCNK
Cyclin-K

1

1

Small-scale

0.500

High

1330574

CDK12
Cyclin-dependent kinase 12

1

2

Small-scale

0.500

High

425825

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

3

High-throughput

0.489

High

425928

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.489

High

1330558

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

4

High-throughput

0.489

High

1330569

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.489

High

1228904

MSL1
Male-specific lethal 1 homolog

1

0

Small-scale

0.480

High

1330566

KAT8
Histone acetyltransferase KAT8

1

0

Small-scale

0.480

High

1330570

MSL2
E3 ubiquitin-protein ligase MSL2

1

0

Small-scale

0.480

High

47009

PNT87
Transcriptional regulator PINT87aa

1

0

Small-scale

0.479

High

129257

MEN1
Menin

1

1

High-throughput

0.479

High

141001

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

160109

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

5

Small-scale

0.479

High

173076

XPO1
Exportin-1

1

2

High-throughput

0.479

High

190995

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

3

High-throughput

0.479

High

269967

AUXI
Auxilin

1

2

High-throughput

0.479

High

346073

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

414215

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

522786

NR2F6
Nuclear receptor subfamily 2 group F member 6

1

2

High-throughput

0.479

High

589166

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

606916

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

695948

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

711155

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

1

Small-scale

0.479

High

714271

PML
Protein PML

1

1

Small-scale

0.479

High

768650

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

839905

AF9
Protein AF-9

1

1

Small-scale

0.479

High

855476

ATRX
Transcriptional regulator ATRX

1

6

Small-scale

0.479

High

879272

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

881565

CDK8
Cyclin-dependent kinase 8

1

2

High-throughput

0.479

High

942747

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

979992

H4
Histone H4

1

2

High-throughput

0.479

High

1037270

H11
Histone H1.1

1

1

Small-scale

0.479

High

1067511

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1094706

CAF1A
Chromatin assembly factor 1 subunit A

1

2

Small-scale

0.479

High

1124375

ELOA1
Elongin-A

1

1

Small-scale

0.479

High

1128059

DHX8
ATP-dependent RNA helicase DHX8

1

1

High-throughput

0.479

High

1129650

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

1132832

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

5

High-throughput

0.479

High

1136274

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.479

High

1161542

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

1194219

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

1235469

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

1254649

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1313261

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1330542

NUP43
Nucleoporin Nup43

1

5

High-throughput

0.479

High

1330548

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.479

High

1330549

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1330550

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

1330551

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.479

High

1330554

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

4

High-throughput

0.479

High

1330556

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1330557

CIC
Protein capicua homolog

1

3

High-throughput

0.479

High

1330561

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1330565

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1330577

DNM3B
DNA

1

1

Small-scale

0.479

High

1330578

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1330580

AGO2
Protein argonaute-2

1

1

Small-scale

0.479

High

1330585

DNM3A
DNA

1

1

Small-scale

0.479

High

157614

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

247998

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

315777

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

681445

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

697180

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

703962

DUS1
Dual specificity protein phosphatase 1

1

0

Small-scale

0.458

High

786726

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.458

High

799984

COIL
Coilin

1

0

High-throughput

0.458

High

862302

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

984852

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

995141

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1040852

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

1042648

UPAR
Urokinase plasminogen activator surface receptor

1

0

Small-scale

0.458

High

1054744

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

1138398

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1213453

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

1289455

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1326833

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

1330552

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1330560

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

1330573

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1330575

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1330582

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

943992

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

1054125

BTK
Tyrosine-protein kinase BTK

1

1

High-throughput

0.445

High

1209391

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

106273

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

412259

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

970783

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

1149444

SKI2
Superkiller complex protein 2

1

1

High-throughput

0.437

High

1244704

TTC33
Tetratricopeptide repeat protein 33

1

1

High-throughput

0.437

High

1276488

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1330545

ASB11
Ankyrin repeat and SOCS box protein 11

1

4

High-throughput

0.437

High

1330563

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.437

High

316414

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

Small-scale

0.426

High

1239877

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.426

High

1330555

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.426

High

1330568

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1330581

AKP8L
A-kinase anchor protein 8-like

1

0

High-throughput

0.426

High

74548

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.279

Low

298203

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.279

Low

572371

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

0

High-throughput

0.279

Low

617548

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.279

Low

634134

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.279

Low

884162

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.279

Low

931405

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.279

Low

1330540

SYT2
Synaptotagmin-2

1

0

High-throughput

0.279

Low

64889

RCCD1
RCC1 domain-containing protein 1

1

0

High-throughput

0.249

Low

1324508

FA43A
Protein FAM43A

1

0

Small-scale

0.249

Low

1330579

TES
Testin

1

0

High-throughput

0.249

Low

337180

APOM
Apolipoprotein M

1

0

High-throughput

0.232

Low

1330576

VSX1
Visual system homeobox 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025