HitPredict

Interactor 1: TP53B (Q12888)
TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Gene: TP53BP1

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29509190
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051091 - positive regulation of DNA-binding transcription factor activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1972 Hs			1 530
+	Hs
		369495 TP53B_HUMAN (1-1972): 0: 766: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377284 TP53B_HUMAN (1-1972): 0: 766: 100.00		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		370263 MINT_HUMAN (2-1787): 6.67e-46: 185: 7.93		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1264774 TITIN_HUMAN (6-1527): 2.77e-31: 137: 9.47		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1056909 MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		370105 TITIN_HUMAN (6-1527): 2.77e-31: 137: 9.47		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1269948 SRRM2_HUMAN (18-1418): 1.61e-14: 82.2: 9.78		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1186078 MICA3_HUMAN (254-923): 1.94e-14: 81.7: 14.49		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269667 MUC5B_HUMAN (991-1688): 7.1e-10: 66.8: 9.19		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369607 MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1270066 PCLO_HUMAN (14-1588): 6.21e-09: 63.7: 7.38		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		782640 MINT_HUMAN (2-1787): 6.67e-46: 185: 7.93		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		377624 MINT_HUMAN (2-1787): 6.67e-46: 185: 7.93		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		370728 SRRM2_HUMAN (18-1418): 1.61e-14: 82.2: 9.78		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377539 TITIN_HUMAN (6-1527): 2.77e-31: 137: 9.47		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		377537 MUC16_HUMAN (4-1716): 5.43e-31: 136: 8.48		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		377720 MXRA5_HUMAN (459-1506): 1.7e-21: 105: 9.83		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Mm
		1142665 RIF1_MOUSE (65-1352): 5.43e-18: 93.6: 12.69		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Hs
		487431 MDC1_HUMAN (10-773): 2.05e-23: 111: 10.33		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59