HitPredict

Interactor 1: GRIK2 (Q13002)
Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)
Gene: GRIK2

Interactor 2: GRIK5 (Q16478)
Glutamate receptor ionotropic, kainate 5 (GluK5) (Excitatory amino acid receptor 2) (EAA2) (Glutamate receptor KA-2) (KA2)
Gene: GRIK5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.912

The method score is based on:

Property Details
Experiments 15583001, 8288598, 9466455, 29058671, 21791290
Identification Methods affinity chromatography technology, pull down, biochemical, x-ray crystallography
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ANF_receptor~ANF_receptor, ANF_receptor~Lig_chan, ANF_receptor~Lig_chan-Glu_bd, Lig_chan~Lig_chan, Lig_chan~Lig_chan-Glu_bd, Lig_chan-Glu_bd~Lig_chan-Glu_bd
Common GO terms GO:0005886 - plasma membrane
GO:0015277 - kainate selective glutamate receptor activity
GO:0032983 - kainate selective glutamate receptor complex
GO:0035249 - synaptic transmission, glutamatergic
GO:0042734 - presynaptic membrane
and 5 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 908
Hs

1 980
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Last updated: 15 Jul 2024