Protein: LSM2
U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)

Gene: LSM2
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q9Y333

Gene Ontology (top 5):
GO:0000244 - spliceosomal tri-snRNP complex assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0000932 - P-body
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

974295

LSM3
U6 snRNA-associated Sm-like protein LSm3

17

20

Small-scale

0.990

High

1460917

LSM7
U6 snRNA-associated Sm-like protein LSm7

7

20

Small-scale

0.965

High

926249

ICLN
Methylosome subunit pICln

6

11

High-throughput

0.953

High

974347

LSM6
U6 snRNA-associated Sm-like protein LSm6

6

19

High-throughput

0.949

High

1137203

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

5

20

High-throughput

0.927

High

973852

RUXE
Small nuclear ribonucleoprotein E

5

14

Small-scale

0.925

High

178058

LSM1
U6 snRNA-associated Sm-like protein LSm1

5

20

High-throughput

0.925

High

574526

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

5

16

High-throughput

0.925

High

974699

SMD2
Small nuclear ribonucleoprotein Sm D2

5

20

Small-scale

0.921

High

1491049

LSM4
U6 snRNA-associated Sm-like protein LSm4

5

16

Small-scale

0.912

High

974087

RUXF
Small nuclear ribonucleoprotein F

4

19

High-throughput

0.903

High

344579

LSM8
U6 snRNA-associated Sm-like protein LSm8

4

20

Small-scale

0.886

High

215213

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

3

7

High-throughput

0.861

High

1287160

PATL1
Protein PAT1 homolog 1

3

6

High-throughput

0.843

High

991274

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

18

High-throughput

0.811

High

1491048

LSM5
U6 snRNA-associated Sm-like protein LSm5

2

20

High-throughput

0.811

High

480359

RU1C
U1 small nuclear ribonucleoprotein C

2

6

High-throughput

0.789

High

1293329

DAA11
Dynein axonemal assembly factor 11

2

14

High-throughput

0.783

High

473202

RU17
U1 small nuclear ribonucleoprotein 70 kDa

2

13

High-throughput

0.754

High

1138792

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

11

High-throughput

0.754

High

1241862

PRP8
Pre-mRNA-processing-splicing factor 8

2

7

High-throughput

0.754

High

848453

MAGA6
Melanoma-associated antigen 6

3

2

High-throughput

0.675

High

209358

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

3

20

High-throughput

0.667

High

1459961

DDX20
Probable ATP-dependent RNA helicase DDX20

2

15

Small-scale

0.624

High

167140

GEMI2
Gem-associated protein 2

1

4

High-throughput

0.618

High

485767

RU2A
U2 small nuclear ribonucleoprotein A'

1

13

High-throughput

0.618

High

974222

RUXG
Small nuclear ribonucleoprotein G

1

20

High-throughput

0.618

High

974495

SMD1
Small nuclear ribonucleoprotein Sm D1

1

14

High-throughput

0.618

High

478265

SNRPA
U1 small nuclear ribonucleoprotein A

2

19

High-throughput

0.611

High

1127270

RBM39
RNA-binding protein 39

2

10

High-throughput

0.611

High

1491047

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

4

Small-scale

0.611

High

848310

MAGA3
Melanoma-associated antigen 3

2

2

High-throughput

0.606

High

1438673

CBX8
Chromobox protein homolog 8

2

1

High-throughput

0.606

High

1490491

LZTS1
Leucine zipper putative tumor suppressor 1

2

2

High-throughput

0.606

High

1367764

PRCC
Proline-rich protein PRCC

2

1

High-throughput

0.600

High

1160625

SMN
Survival motor neuron protein

2

9

Small-scale

0.595

High

1194476

LARP7
La-related protein 7

2

12

High-throughput

0.584

High

1271926

MEPCE
7SK snRNA methylphosphate capping enzyme

2

5

High-throughput

0.584

High

868800

LEG7
Galectin-7

2

0

High-throughput

0.580

High

1187098

LSM12
Protein LSM12

2

0

High-throughput

0.580

High

894259

MEOX2
Homeobox protein MOX-2

1

2

High-throughput

0.573

High

1049068

REL
Proto-oncogene c-Rel

1

3

High-throughput

0.573

High

1348588

LNX1
E3 ubiquitin-protein ligase LNX

1

2

High-throughput

0.573

High

1419273

TRI54
Tripartite motif-containing protein 54

1

6

High-throughput

0.573

High

728029

DNJA1
DnaJ homolog subfamily A member 1

2

0

Small-scale

0.565

High

1437022

ZN408
Zinc finger protein 408

2

0

Small-scale

0.565

High

1061925

TLE5
TLE family member 5

1

0

High-throughput

0.549

High

1332069

BANP
Protein BANP

1

0

High-throughput

0.549

High

1394568

RSRC1
Serine/Arginine-related protein 53

1

1

High-throughput

0.541

High

1336512

PNMA1
Paraneoplastic antigen Ma1

1

0

High-throughput

0.536

High

483270

CLCA
Clathrin light chain A

1

3

High-throughput

0.536

High

483421

CLCB
Clathrin light chain B

1

3

High-throughput

0.536

High

542293

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

651036

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

5

High-throughput

0.536

High

854395

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.536

High

872917

SOX2
Transcription factor SOX-2

1

7

High-throughput

0.536

High

1005520

RBM6
RNA-binding protein 6

1

9

High-throughput

0.536

High

1065508

SSRP1
FACT complex subunit SSRP1

1

7

High-throughput

0.536

High

1094661

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

4

High-throughput

0.536

High

1149232

SF3A1
Splicing factor 3A subunit 1

1

6

High-throughput

0.536

High

1160349

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

10

High-throughput

0.536

High

1360536

PSPC1
Paraspeckle component 1

1

3

High-throughput

0.536

High

1413426

RBM42
RNA-binding protein 42

1

12

High-throughput

0.536

High

1447869

DDX21
Nucleolar RNA helicase 2

1

10

High-throughput

0.536

High

736932

GBP2
Guanylate-binding protein 2

1

0

High-throughput

0.518

High

1051443

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

High-throughput

0.518

High

1123243

DPYL1
Dihydropyrimidinase-related protein 1

1

0

High-throughput

0.518

High

1105447

SF3B2
Splicing factor 3B subunit 2

1

4

High-throughput

0.508

High

1032272

EXOSX
Exosome complex component 10

1

0

High-throughput

0.486

High

566324

K1C13
Keratin, type I cytoskeletal 13

1

1

High-throughput

0.481

High

158018

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

162743

ANM5
Protein arginine N-methyltransferase 5

1

4

High-throughput

0.479

High

216297

PPIH
Peptidyl-prolyl cis-trans isomerase H

1

6

High-throughput

0.479

High

222550

PLRG1
Pleiotropic regulator 1

1

15

High-throughput

0.479

High

245174

AQR
RNA helicase aquarius

1

5

High-throughput

0.479

High

248158

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

251050

PRP17
Pre-mRNA-processing factor 17

1

20

High-throughput

0.479

High

257286

PQBP1
Polyglutamine-binding protein 1

1

1

High-throughput

0.479

High

289735

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

20

High-throughput

0.479

High

316193

RECQ4
ATP-dependent DNA helicase Q4

1

13

High-throughput

0.479

High

321701

PRP6
Pre-mRNA-processing factor 6

1

15

High-throughput

0.479

High

325181

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

335942

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

3

High-throughput

0.479

High

430544

JUN
Transcription factor Jun

1

5

High-throughput

0.479

High

607250

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

800184

COIL
Coilin

1

2

High-throughput

0.479

High

867542

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.479

High

895172

EMD
Emerin

1

1

Small-scale

0.479

High

914005

RBM5
RNA-binding protein 5

1

4

High-throughput

0.479

High

935325

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

944598

GEMI4
Gem-associated protein 4

1

1

High-throughput

0.479

High

965353

WDR5
WD repeat-containing protein 5

1

20

High-throughput

0.479

High

980579

H4
Histone H4

1

4

High-throughput

0.479

High

1013505

LSM11
U7 snRNA-associated Sm-like protein LSm11

1

2

High-throughput

0.479

High

1091797

PP1R8
Nuclear inhibitor of protein phosphatase 1

1

5

High-throughput

0.479

High

1095199

RED
Protein Red

1

1

High-throughput

0.479

High

1111378

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.479

High

1229261

RHG17
Rho GTPase-activating protein 17

1

4

High-throughput

0.479

High

1241526

EDC4
Enhancer of mRNA-decapping protein 4

1

1

High-throughput

0.479

High

1256201

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1290842

ZCH18
Zinc finger CCCH domain-containing protein 18

1

6

High-throughput

0.479

High

1324931

RHG18
Rho GTPase-activating protein 18

1

5

High-throughput

0.479

High

1327484

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

7

Small-scale

0.479

High

1331138

PDCD7
Programmed cell death protein 7

1

2

High-throughput

0.479

High

1335093

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1336337

LS14A
Protein LSM14 homolog A

1

6

Small-scale

0.479

High

1359960

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

8

High-throughput

0.479

High

1360315

GEMI6
Gem-associated protein 6

1

4

High-throughput

0.479

High

1361548

CTBL1
Beta-catenin-like protein 1

1

1

High-throughput

0.479

High

1365276

HS105
Heat shock protein 105 kDa

1

3

High-throughput

0.479

High

1367650

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1385658

DCPS
m7GpppX diphosphatase

1

3

High-throughput

0.479

High

1387658

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

14

High-throughput

0.479

High

1390428

EDC3
Enhancer of mRNA-decapping protein 3

1

2

High-throughput

0.479

High

1404532

CDC5L
Cell division cycle 5-like protein

1

8

High-throughput

0.479

High

1411768

RIOK1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

1414628

DDX23
Probable ATP-dependent RNA helicase DDX23

1

13

High-throughput

0.479

High

1419986

CRNL1
Crooked neck-like protein 1

1

20

High-throughput

0.479

High

1431354

ATG5
Autophagy protein 5

1

2

High-throughput

0.479

High

1437826

BRF2
Transcription factor IIIB 50 kDa subunit

1

3

Small-scale

0.479

High

1439241

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

4

Small-scale

0.479

High

1447705

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

3

High-throughput

0.479

High

1451087

RBM22
Pre-mRNA-splicing factor RBM22

1

8

High-throughput

0.479

High

1451592

GEMI8
Gem-associated protein 8

1

3

High-throughput

0.479

High

1459399

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1461925

FZR1
Fizzy-related protein homolog

1

14

High-throughput

0.479

High

1490966

WBP11
WW domain-binding protein 11

1

1

High-throughput

0.479

High

1491046

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

6

High-throughput

0.479

High

1491050

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

1

3

High-throughput

0.479

High

49916

A1A4E9
Keratin 13

1

1

High-throughput

0.470

High

1143603

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.460

High

648256

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.458

High

913911

ZN143
Zinc finger protein 143

1

0

Small-scale

0.458

High

1339898

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

0

High-throughput

0.458

High

3682

NBDY
Negative regulator of P-body association

1

1

Small-scale

0.445

High

328200

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

12

High-throughput

0.445

High

1119385

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

2

High-throughput

0.445

High

1430369

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

12

High-throughput

0.445

High

539858

RALA
Ras-related protein Ral-A

1

1

Small-scale

0.439

High

344376

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

887365

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.408

High

1315009

TEX11
Testis-expressed protein 11

1

0

High-throughput

0.292

High

1461201

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.282

High

418529

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025