HitPredict

Interactor 1: PRDM2 (Q13029)
PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ)
Gene: PRDM2

Interactor 2: CTBP1 (Q13363)
C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)
Gene: CTBP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.712

Property	Details
Experiments	26186194, 28514442, 33961781, 35016035, 31041561
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1718 Hs			1 440
+	Hs
		974550 MECOM_HUMAN (1131-1241): 9.31e-12: 72.5: 21.17		CTBP1_HUMAN (1-440): 0: 547: 100.00
+	Mm
		56925 PRD16_MOUSE (1134-1379): 2.1e-11: 71.4: 18.44		CTBP1_MOUSE (1-440): 0: 545: 98.64
+	Hs
		881146 MECOM_HUMAN (1131-1241): 9.31e-12: 72.5: 21.17		CTBP2_HUMAN (10-439): 0: 538: 80.23
+	Hs
		1032624 PRD16_HUMAN (18-138): 7.86e-09: 62.8: 33.09		CTBP1_HUMAN (1-440): 0: 547: 100.00
+	Hs
		881300 PRD16_HUMAN (18-138): 7.86e-09: 62.8: 33.09		CTBP2_HUMAN (10-439): 0: 538: 80.23
+	Hs
		1343654 PRDM7_HUMAN (19-150): 3.01e-51: 191: 34.59		GRHPR_HUMAN (12-348): 1.18e-111: 333: 24.78
+	Hs
		197281 MECOM_HUMAN (1131-1241): 9.31e-12: 72.5: 21.17		SERA_HUMAN (29-404): 9.81e-121: 363: 29.23
+	Hs
		1343652 PRDM9_HUMAN (302-412): 1.68e-14: 81.4: 23.14		GRHPR_HUMAN (12-348): 1.18e-111: 333: 24.78