Protein: RNF26
E3 ubiquitin-protein ligase RNF26 (EC 2.3.2.27) (RING finger protein 26)

Gene: RNF26
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q9BY78

Gene Ontology (top 5):
GO:0005789 - endoplasmic reticulum membrane
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0007032 - endosome organization
GO:0008270 - zinc ion binding
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

957184

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

High-throughput

0.801

High

982305

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

High-throughput

0.801

High

1383928

UBE2W
Ubiquitin-conjugating enzyme E2 W

2

20

High-throughput

0.801

High

906768

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

20

High-throughput

0.781

High

1417844

RNF26
E3 ubiquitin-protein ligase RNF26

2

15

Small-scale

0.778

High

952465

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

High-throughput

0.698

High

913902

ZN143
Zinc finger protein 143

3

1

High-throughput

0.667

High

909385

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.656

High

1417857

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.656

High

987194

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

8

Small-scale

0.647

High

295874

FACE1
CAAX prenyl protease 1 homolog

3

0

High-throughput

0.638

High

1218754

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

1281071

UB2Q1
Ubiquitin-conjugating enzyme E2 Q1

1

4

High-throughput

0.625

High

1292872

STING
Stimulator of interferon genes protein

2

4

Small-scale

0.624

High

1417858

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

20

Small-scale

0.618

High

1108112

SQSTM
Sequestosome-1

2

4

Small-scale

0.595

High

1290961

TAXB1
Tax1-binding protein 1

2

6

Small-scale

0.595

High

1417847

TOLIP
Toll-interacting protein

2

2

Small-scale

0.595

High

1417853

PSME2
Proteasome activator complex subunit 2

2

2

High-throughput

0.574

High

976773

ERF1
Eukaryotic peptide chain release factor subunit 1

2

1

High-throughput

0.558

High

1054641

PSME1
Proteasome activator complex subunit 1

2

2

High-throughput

0.558

High

839817

EPS15
Epidermal growth factor receptor substrate 15

2

4

Small-scale

0.543

High

1164547

MIC60
MICOS complex subunit MIC60

2

1

Small-scale

0.543

High

1417859

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

11

Small-scale

0.543

High

1384220

LDAF1
Lipid droplet assembly factor 1

1

0

High-throughput

0.513

High

474953

VIME
Vimentin

1

6

Small-scale

0.512

High

248240

NDK8
Putative nucleoside diphosphate kinase

2

1

High-throughput

0.504

High

273579

DJC13
DnaJ homolog subfamily C member 13

1

4

Small-scale

0.501

High

294795

CAN15
Calpain-15

1

7

Small-scale

0.501

High

535491

BIP
Endoplasmic reticulum chaperone BiP

1

8

Small-scale

0.501

High

1121513

KEAP1
Kelch-like ECH-associated protein 1

1

1

Small-scale

0.501

High

1157907

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.501

High

1389369

RNF31
E3 ubiquitin-protein ligase RNF31

1

7

Small-scale

0.501

High

1402244

WRIP1
ATPase WRNIP1

1

6

Small-scale

0.501

High

1417845

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

4

Small-scale

0.501

High

1417848

SHRPN
Sharpin

1

4

Small-scale

0.501

High

1364985

TSC1
Hamartin

1

7

Small-scale

0.489

High

1417851

ANM8
Protein arginine N-methyltransferase 8

1

2

High-throughput

0.489

High

133792

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

2

High-throughput

0.479

High

360103

NB5R3
NADH-cytochrome b5 reductase 3

1

1

High-throughput

0.479

High

367611

CAH2
Carbonic anhydrase 2

1

1

High-throughput

0.479

High

627703

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

2

High-throughput

0.479

High

631691

RAB6A
Ras-related protein Rab-6A

1

5

High-throughput

0.479

High

698014

CALR
Calreticulin

1

5

Small-scale

0.479

High

699077

CALX
Calnexin

1

5

Small-scale

0.479

High

944321

TMM33
Transmembrane protein 33

1

1

High-throughput

0.479

High

956471

RAB2A
Ras-related protein Rab-2A

1

6

High-throughput

0.479

High

1051848

EF1A2
Elongation factor 1-alpha 2

1

6

High-throughput

0.479

High

1105871

TMED1
Transmembrane emp24 domain-containing protein 1

1

1

High-throughput

0.479

High

1208114

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

2

High-throughput

0.479

High

1214668

RBM26
RNA-binding protein 26

1

3

High-throughput

0.479

High

1413692

TMM43
Transmembrane protein 43

1

1

High-throughput

0.479

High

1417849

RAB1B
Ras-related protein Rab-1B

1

5

High-throughput

0.479

High

1417862

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

1

High-throughput

0.479

High

916193

BIEA
Biliverdin reductase A

1

0

High-throughput

0.458

High

1417854

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.458

High

254217

CTND1
Catenin delta-1

1

7

Small-scale

0.457

High

360214

GSHR
Glutathione reductase, mitochondrial

1

2

Small-scale

0.457

High

407519

K2C1
Keratin, type II cytoskeletal 1

1

2

Small-scale

0.457

High

425018

ADT2
ADP/ATP translocase 2

1

4

Small-scale

0.457

High

457988

TRY1
Serine protease 1

1

3

Small-scale

0.457

High

479862

GSTP1
Glutathione S-transferase P

1

1

Small-scale

0.457

High

537844

HSP7C
Heat shock cognate 71 kDa protein

1

7

Small-scale

0.457

High

566204

K1C10
Keratin, type I cytoskeletal 10

1

2

Small-scale

0.457

High

566444

K2C5
Keratin, type II cytoskeletal 5

1

2

Small-scale

0.457

High

592896

CBR1
Carbonyl reductase [NADPH] 1

1

3

Small-scale

0.457

High

688133

EF1G
Elongation factor 1-gamma

1

2

Small-scale

0.457

High

777548

K22E
Keratin, type II cytoskeletal 2 epidermal

1

3

Small-scale

0.457

High

801508

HSPA9
Stress-70 protein, mitochondrial

1

12

Small-scale

0.457

High

876498

K2C6C
Keratin, type II cytoskeletal 6C

1

2

Small-scale

0.457

High

892503

GUAA
GMP synthase [glutamine-hydrolyzing]

1

2

Small-scale

0.457

High

913034

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

10

Small-scale

0.457

High

965862

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

10

Small-scale

0.457

High

996838

TBA1B
Tubulin alpha-1B chain

1

5

Small-scale

0.457

High

1199183

PAR10
Protein mono-ADP-ribosyltransferase PARP10

1

2

Small-scale

0.457

High

1256902

TM1L2
TOM1-like protein 2

1

2

Small-scale

0.457

High

1295711

HORN
Hornerin

1

3

Small-scale

0.457

High

1324999

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

8

Small-scale

0.457

High

1403225

MA7D2
MAP7 domain-containing protein 2

1

3

Small-scale

0.457

High

1417852

RCC2
Protein RCC2

1

3

Small-scale

0.457

High

1417855

MYO6
Unconventional myosin-VI

1

2

Small-scale

0.457

High

221658

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

1

High-throughput

0.437

High

322057

ENDD1
Endonuclease domain-containing 1 protein

1

1

High-throughput

0.437

High

549230

CDK4
Cyclin-dependent kinase 4

1

5

Small-scale

0.437

High

690370

STOM
Stomatin

1

6

High-throughput

0.437

High

1015107

ARF5
ADP-ribosylation factor 5

1

5

High-throughput

0.437

High

1029031

TIAR
Nucleolysin TIAR

1

1

High-throughput

0.437

High

1229859

CYTSA
Cytospin-A

1

3

High-throughput

0.437

High

1250829

RFIP1
Rab11 family-interacting protein 1

1

5

High-throughput

0.437

High

1386356

FAF2
FAS-associated factor 2

1

5

High-throughput

0.437

High

1394189

LRCH3
DISP complex protein LRCH3

1

2

High-throughput

0.437

High

1417860

SAM50
Sorting and assembly machinery component 50 homolog

1

1

High-throughput

0.437

High

1417861

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

1

High-throughput

0.437

High

1417856

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.426

High

190254

MOT4
Monocarboxylate transporter 4

1

1

High-throughput

0.407

High

1199092

CTL4
Choline transporter-like protein 4

1

1

High-throughput

0.407

High

1359494

CTL1
Choline transporter-like protein 1

1

1

High-throughput

0.407

High

1417850

CUED2
CUE domain-containing protein 2

3

0

High-throughput

0.347

High

1417846

NAA50
N-alpha-acetyltransferase 50

2

0

High-throughput

0.328

High

1081472

INCA1
Protein INCA1

1

0

Small-scale

0.288

High

1131223

MESD
LRP chaperone MESD

1

0

High-throughput

0.279

Low

1308878

CCD50
Coiled-coil domain-containing protein 50

1

0

Small-scale

0.261

Low

1398829

DOCK7
Dedicator of cytokinesis protein 7

1

0

Small-scale

0.261

Low

1403717

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

Small-scale

0.261

Low

281655

MTX2
Metaxin-2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025