HitPredict

Interactor 1: CDC16 (Q13042)
Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6)
Gene: CDC16

Interactor 2: MD2L1 (Q13257)
Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1)
Gene: MAD2L1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	33961781, 9356466, 20360068
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0051301 - cell division GO:0072686 - mitotic spindle
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 620 Hs			1 205
+	Sc
		454914 CDC16_YEAST (3-581): 1.58e-77: 265: 30.17		MAD2_YEAST (9-200): 6.6e-76: 228: 43.15
+	Sp
		145600 CUT9_SCHPO (3-598): 2.2e-72: 247: 31.33		MAD2_SCHPO (3-201): 9.71e-83: 245: 45.50
+	Hs
		1029248 Q4KMX6_HUMAN (75-607): 2.94e-19: 93.7: 12.73		MD2L1_HUMAN (1-205): 1.58e-99: 288: 100.00
+	Hs
		1029346 APC7_HUMAN (75-607): 2.88e-19: 93.7: 12.73		MD2L1_HUMAN (1-205): 1.58e-99: 288: 100.00
+	Hs
		1029345 CDC23_HUMAN (9-383): 2.3e-15: 81.4: 9.71		MD2L1_HUMAN (1-205): 1.58e-99: 288: 100.00
+	Hs
		672824 CDC27_HUMAN (4-194): 3.68e-15: 81: 17.80		MD2L1_HUMAN (1-205): 1.58e-99: 288: 100.00
+	Sp
		145598 APC8_SCHPO (3-180): 1.31e-09: 62.9: 11.46		MAD2_SCHPO (3-201): 9.71e-83: 245: 45.50
+	Hs
		672915 CDC27_HUMAN (4-194): 3.68e-15: 81: 17.80		MD2L2_HUMAN (17-203): 6e-62: 193: 22.73