Protein: BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1)

Gene: BIG1, ARFGEF1
Organism: Homo sapiens
Interactions: 131
UniProt ID: Q9Y6D6

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1491832

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

5

9

Small-scale

0.924

High

1404079

MYCBP
c-Myc-binding protein

4

1

Small-scale

0.703

High

1351837

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

3

1

High-throughput

0.667

High

1462797

LAMP3
Lysosome-associated membrane glycoprotein 3

3

7

High-throughput

0.667

High

1278706

KI21A
Kinesin-like protein KIF21A

2

2

Small-scale

0.621

High

1420492

DPY30
Protein dpy-30 homolog

2

1

Small-scale

0.619

High

827291

ARL1
ADP-ribosylation factor-like protein 1

1

20

High-throughput

0.618

High

975352

ARF6
ADP-ribosylation factor 6

1

16

High-throughput

0.618

High

531188

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

5

Small-scale

0.594

High

620679

NUCL
Nucleolin

2

0

Small-scale

0.585

High

789258

NUP62
Nuclear pore glycoprotein p62

2

0

Small-scale

0.585

High

976704

RB11A
Ras-related protein Rab-11A

2

7

High-throughput

0.584

High

665332

EDNRB
Endothelin receptor type B

2

9

High-throughput

0.574

High

879823

NPY2R
Neuropeptide Y receptor type 2

2

5

High-throughput

0.574

High

1330766

SIGL1
SIGLEC family-like protein 1

2

3

High-throughput

0.574

High

212516

SPIT2
Kunitz-type protease inhibitor 2

2

3

High-throughput

0.571

High

1129933

KANK1
KN motif and ankyrin repeat domain-containing protein 1

1

8

Small-scale

0.569

High

1101327

SLAF1
Signaling lymphocytic activation molecule

2

10

High-throughput

0.558

High

1434369

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

765159

CTNB1
Catenin beta-1

1

3

Small-scale

0.552

High

380212

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

6

High-throughput

0.552

High

139369

UPK2
Uroplakin-2

2

4

High-throughput

0.549

High

1037928

HEN2
Helix-loop-helix protein 2

2

3

High-throughput

0.549

High

1101719

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

17

High-throughput

0.549

High

1446731

TMM9B
Transmembrane protein 9B

2

6

High-throughput

0.549

High

1448680

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

2

6

High-throughput

0.549

High

1490562

VSIG4
V-set and immunoglobulin domain-containing protein 4

2

7

High-throughput

0.549

High

1106252

MYO9B
Unconventional myosin-IXb

1

2

Small-scale

0.536

High

220646

AKA10
A-kinase anchor protein 10, mitochondrial

1

2

High-throughput

0.536

High

273603

DJC13
DnaJ homolog subfamily C member 13

1

7

High-throughput

0.536

High

431290

LA
Lupus La protein

1

1

Small-scale

0.536

High

774740

BASI
Basigin

1

9

High-throughput

0.536

High

846706

MSH2
DNA mismatch repair protein Msh2

1

1

High-throughput

0.536

High

868031

GLR
Glucagon receptor

1

3

High-throughput

0.536

High

913435

MSH6
DNA mismatch repair protein Msh6

1

1

High-throughput

0.536

High

1159255

SGCA
Alpha-sarcoglycan

1

1

High-throughput

0.536

High

1324893

LRC25
Leucine-rich repeat-containing protein 25

1

2

High-throughput

0.536

High

1399658

OPALI
Opalin

1

2

High-throughput

0.536

High

1454034

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

6

High-throughput

0.536

High

1491495

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

4

High-throughput

0.536

High

1491517

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

4

High-throughput

0.536

High

437406

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.515

High

1027886

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.515

High

644167

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

Small-scale

0.513

High

1244424

BORA
Protein aurora borealis

1

0

High-throughput

0.513

High

1292427

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.513

High

1316742

AGRG2
Adhesion G-protein coupled receptor G2

1

0

High-throughput

0.513

High

689913

FKBP2
Peptidyl-prolyl cis-trans isomerase FKBP2

1

1

Small-scale

0.504

High

1126263

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

3

Small-scale

0.500

High

1333801

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.493

High

182862

GP182
G-protein coupled receptor 182

1

18

High-throughput

0.489

High

634822

GRAH
Granzyme H

1

4

High-throughput

0.489

High

638564

FPR1
fMet-Leu-Phe receptor

1

10

High-throughput

0.489

High

683382

TNR5
Tumor necrosis factor receptor superfamily member 5

1

8

High-throughput

0.489

High

700812

DMB
HLA class II histocompatibility antigen, DM beta chain

1

6

High-throughput

0.489

High

922855

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

2

High-throughput

0.489

High

1022997

EFNB1
Ephrin-B1

1

2

High-throughput

0.489

High

1090121

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

7

High-throughput

0.489

High

1132599

FXYD3
FXYD domain-containing ion transport regulator 3

1

1

High-throughput

0.489

High

1158333

RM23
Large ribosomal subunit protein uL23m

1

1

High-throughput

0.489

High

1165214

TATD3
Deoxyribonuclease TATDN3

1

1

High-throughput

0.489

High

1286759

CLC14
C-type lectin domain family 14 member A

1

1

High-throughput

0.489

High

1291930

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

20

High-throughput

0.489

High

1325968

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

3

High-throughput

0.489

High

1350931

HUMMR
Protein MGARP

1

3

High-throughput

0.489

High

1387015

ORAI1
Calcium release-activated calcium channel protein 1

1

1

High-throughput

0.489

High

1430713

F234A
Protein FAM234A

1

2

High-throughput

0.489

High

1460043

CLC2D
C-type lectin domain family 2 member D

1

5

High-throughput

0.489

High

1462648

KCNH4
Voltage-gated delayed rectifier potassium channel KCNH4

1

3

High-throughput

0.489

High

1491775

GPR45
Probable G-protein coupled receptor 45

1

5

High-throughput

0.489

High

1491801

NPTN
Neuroplastin

1

11

High-throughput

0.489

High

140046

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.479

High

180124

BET1
BET1 homolog

1

7

High-throughput

0.479

High

219033

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

226286

STX6
Syntaxin-6

1

7

High-throughput

0.479

High

364100

EGFR
Epidermal growth factor receptor

1

9

High-throughput

0.479

High

375055

RASH
GTPase HRas

1

11

High-throughput

0.479

High

412903

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.479

High

538189

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

562523

LAMP2
Lysosome-associated membrane glycoprotein 2

1

7

High-throughput

0.479

High

590162

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

604296

CXA1
Gap junction alpha-1 protein

1

6

High-throughput

0.479

High

631050

RAB4A
Ras-related protein Rab-4A

1

17

High-throughput

0.479

High

769647

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

786962

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

Small-scale

0.479

High

799620

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

901722

RAB7A
Ras-related protein Rab-7a

1

19

High-throughput

0.479

High

902172

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.479

High

956562

RAB2A
Ras-related protein Rab-2A

1

12

High-throughput

0.479

High

1142050

EEA1
Early endosome antigen 1

1

2

High-throughput

0.479

High

1247071

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1294873

STX12
Syntaxin-12

1

3

High-throughput

0.479

High

1356424

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

1

High-throughput

0.479

High

1356487

TB22A
TBC1 domain family member 22A

1

2

High-throughput

0.479

High

1454878

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

129605

MEN1
Menin

1

0

High-throughput

0.458

High

616249

PGAM1
Phosphoglycerate mutase 1

1

0

High-throughput

0.458

High

906228

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

1106770

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1310066

DEN6A
Protein DENND6A

1

0

High-throughput

0.458

High

1333388

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1448606

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

171626

S27A2
Long-chain fatty acid transport protein 2

1

6

High-throughput

0.445

High

1227802

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.445

High

1234039

S35E4
Solute carrier family 35 member E4

1

3

High-throughput

0.445

High

1332343

NLS1
Sodium-dependent lysophosphatidylcholine symporter 1

1

1

High-throughput

0.445

High

1449702

TB22B
TBC1 domain family member 22B

1

2

Small-scale

0.445

High

1449968

S39A9
Zinc transporter ZIP9

1

3

High-throughput

0.445

High

1210140

SNP47
Synaptosomal-associated protein 47

1

0

Small-scale

0.438

High

277446

TP4A3
Protein tyrosine phosphatase type IVA 3

1

3

High-throughput

0.437

High

294610

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.437

High

516790

SCHI1
Schwannomin-interacting protein 1

1

1

High-throughput

0.437

High

1233621

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.437

High

1249380

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1256309

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1323064

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.437

High

1420335

CD244
Natural killer cell receptor 2B4

1

8

High-throughput

0.437

High

1431809

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.437

High

1452743

ELOV5
Very long chain fatty acid elongase 5

1

3

High-throughput

0.437

High

704099

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.407

High

1010991

BAT1
b(0,+)-type amino acid transporter 1

1

5

High-throughput

0.407

High

1053094

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.407

High

1397207

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

9

High-throughput

0.407

High

1431310

DJC25
DnaJ homolog subfamily C member 25

1

4

High-throughput

0.407

High

1462630

XCT
Cystine/glutamate transporter

1

5

High-throughput

0.407

High

352658

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

1231725

PVRIG
Transmembrane protein PVRIG

3

0

High-throughput

0.347

High

1022508

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.279

Low

1420869

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

1490688

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.249

Low

379591

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025