Protein: EFNA4
Ephrin-A4 (EPH-related receptor tyrosine kinase ligand 4) (LERK-4)

Gene: EFNA4
Organism: Homo sapiens
Interactions: 234
UniProt ID: P52798

Gene Ontology (top 5):
GO:0005005 - transmembrane-ephrin receptor activity
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0007267 - cell-cell signaling
GO:0007411 - axon guidance

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

914227

EPHA4
Ephrin type-A receptor 4

3

20

Small-scale

0.853

High

710134

EPHA2
Ephrin type-A receptor 2

2

20

High-throughput

0.789

High

914367

EPHA6
Ephrin type-A receptor 6

2

20

High-throughput

0.789

High

710689

EPHA8
Ephrin type-A receptor 8

1

20

High-throughput

0.691

High

710609

EPHA3
Ephrin type-A receptor 3

1

20

Small-scale

0.647

High

914264

EPHA7
Ephrin type-A receptor 7

1

20

Small-scale

0.647

High

914226

EFNA4
Ephrin-A4

1

5

High-throughput

0.618

High

914337

TM147
BOS complex subunit TMEM147

2

0

High-throughput

0.580

High

125883

ARVC
Splicing regulator ARVCF

1

3

High-throughput

0.536

High

291071

UTP20
Small subunit processome component 20 homolog

1

1

High-throughput

0.536

High

637867

NF1
Neurofibromin

1

4

High-throughput

0.536

High

896709

DYN2
Dynamin-2

1

6

High-throughput

0.536

High

897559

KNTC1
Kinetochore-associated protein 1

1

1

High-throughput

0.536

High

914230

CXCR4
C-X-C chemokine receptor type 4

1

3

High-throughput

0.536

High

914247

DYN1
Dynamin-1

1

6

High-throughput

0.536

High

914248

SOS1
Son of sevenless homolog 1

1

1

High-throughput

0.536

High

914267

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

1

High-throughput

0.536

High

914305

CIP2A
Protein CIP2A

1

5

High-throughput

0.536

High

914330

XPO6
Exportin-6

1

1

High-throughput

0.536

High

914340

TTYH3
Protein tweety homolog 3

1

1

High-throughput

0.536

High

914364

S53A1
Solute carrier family 53 member 1

1

1

High-throughput

0.536

High

914374

MINP1
Multiple inositol polyphosphate phosphatase 1

1

3

High-throughput

0.536

High

914376

DYN3
Dynamin-3

1

6

High-throughput

0.536

High

297178

PRAF3
PRA1 family protein 3

1

0

High-throughput

0.513

High

898060

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

0

High-throughput

0.513

High

914294

EXOC8
Exocyst complex component 8

1

0

High-throughput

0.513

High

914296

DOCK4
Dedicator of cytokinesis protein 4

1

0

High-throughput

0.513

High

914303

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.513

High

914310

THEM6
Protein THEM6

1

0

High-throughput

0.513

High

914316

SYMPK
Symplekin

1

0

High-throughput

0.513

High

914323

COQ8B
Atypical kinase COQ8B, mitochondrial

1

0

High-throughput

0.513

High

914325

COG3
Conserved oligomeric Golgi complex subunit 3

1

0

High-throughput

0.513

High

914355

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.513

High

60316

NBAS
NBAS subunit of NRZ tethering complex

1

1

High-throughput

0.489

High

135554

DNM1L
Dynamin-1-like protein

1

6

High-throughput

0.489

High

164550

TNPO2
Transportin-2

1

7

High-throughput

0.489

High

173684

BTAF1
TATA-binding protein-associated factor 172

1

1

High-throughput

0.489

High

208034

TTI1
TELO2-interacting protein 1 homolog

1

2

High-throughput

0.489

High

211762

ZW10
Centromere/kinetochore protein zw10 homolog

1

1

High-throughput

0.489

High

220888

XPOT
Exportin-T

1

9

High-throughput

0.489

High

243913

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

5

High-throughput

0.489

High

914242

PRKDC
DNA-dependent protein kinase catalytic subunit

1

4

High-throughput

0.489

High

914251

ATM
Serine-protein kinase ATM

1

5

High-throughput

0.489

High

914255

ATR
Serine/threonine-protein kinase ATR

1

5

High-throughput

0.489

High

914261

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.489

High

914282

THADA
tRNA

1

2

High-throughput

0.489

High

914285

5MP2
eIF5-mimic protein 2

1

4

High-throughput

0.489

High

914286

DYM
Dymeclin

1

1

High-throughput

0.489

High

914287

HEAT3
HEAT repeat-containing protein 3

1

2

High-throughput

0.489

High

914292

DAAF5
Dynein axonemal assembly factor 5

1

1

High-throughput

0.489

High

914295

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

1

High-throughput

0.489

High

914300

STAG2
Cohesin subunit SA-2

1

1

High-throughput

0.489

High

914309

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

1

High-throughput

0.489

High

914312

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.489

High

914319

UPP
Uracil phosphoribosyltransferase homolog

1

1

High-throughput

0.489

High

914322

GCP3
Gamma-tubulin complex component 3

1

2

High-throughput

0.489

High

914327

VPS50
Syndetin

1

1

High-throughput

0.489

High

914329

COG8
Conserved oligomeric Golgi complex subunit 8

1

1

High-throughput

0.489

High

914347

XPO5
Exportin-5

1

7

High-throughput

0.489

High

914353

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

1

High-throughput

0.489

High

914357

UCKL1
Uridine-cytidine kinase-like 1

1

1

High-throughput

0.489

High

914361

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

2

High-throughput

0.489

High

914369

XPO7
Exportin-7

1

8

High-throughput

0.489

High

914370

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

3

High-throughput

0.489

High

914371

KDIS
Kinase D-interacting substrate of 220 kDa

1

1

High-throughput

0.489

High

914383

TNPO3
Transportin-3

1

10

High-throughput

0.489

High

914385

5MP1
eIF5-mimic protein 1

1

4

High-throughput

0.489

High

914293

TARG1
Trafficking regulator of GLUT4 1

1

1

High-throughput

0.481

High

389994

ALBU
Albumin

1

2

High-throughput

0.479

High

407417

K2C1
Keratin, type II cytoskeletal 1

1

19

High-throughput

0.479

High

452210

PDIA1
Protein disulfide-isomerase

1

4

High-throughput

0.479

High

456211

CATD
Cathepsin D

1

1

High-throughput

0.479

High

457325

TBB5
Tubulin beta chain

1

15

High-throughput

0.479

High

470424

ITA2B
Integrin alpha-IIb

1

3

High-throughput

0.479

High

474567

VIME
Vimentin

1

20

High-throughput

0.479

High

534818

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

536803

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

538833

GTR3
Solute carrier family 2, facilitated glucose transporter member 3

1

1

High-throughput

0.479

High

551775

CO6A1

1

1

High-throughput

0.479

High

573398

ENPL
Endoplasmin

1

2

High-throughput

0.479

High

577674

PLAK
Junction plakoglobin

1

1

High-throughput

0.479

High

582561

PPAP
Prostatic acid phosphatase

1

3

High-throughput

0.479

High

584956

GNS
N-acetylglucosamine-6-sulfatase

1

2

High-throughput

0.479

High

587594

DESP
Desmoplakin

1

5

High-throughput

0.479

High

658050

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

680287

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

683590

ITA3
Integrin alpha-3

1

3

High-throughput

0.479

High

702178

LYOX
Protein-lysine 6-oxidase

1

4

High-throughput

0.479

High

914229

ACTB
Actin, cytoplasmic 1

1

4

High-throughput

0.479

High

914232

LYSC
Lysozyme C

1

1

High-throughput

0.479

High

914238

RAC1
Ras-related C3 botulinum toxin substrate 1

1

15

High-throughput

0.479

High

914239

EF1A1
Elongation factor 1-alpha 1

1

2

High-throughput

0.479

High

914245

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

914249

LG3BP
Galectin-3-binding protein

1

4

High-throughput

0.479

High

914254

TBB3
Tubulin beta-3 chain

1

15

High-throughput

0.479

High

914262

PDIA6
Protein disulfide-isomerase A6

1

4

High-throughput

0.479

High

914270

TB10B
TBC1 domain family member 10B

1

3

High-throughput

0.479

High

914283

NEK10
Serine/threonine-protein kinase Nek10

1

1

High-throughput

0.479

High

914284

TBA1A
Tubulin alpha-1A chain

1

12

High-throughput

0.479

High

914288

CNTRL
Centriolin

1

6

High-throughput

0.479

High

914290

CCD25
Coiled-coil domain-containing protein 25

1

1

High-throughput

0.479

High

914313

PXDN
Peroxidasin homolog

1

1

High-throughput

0.479

High

914324

RSPRY
RING finger and SPRY domain-containing protein 1

1

1

High-throughput

0.479

High

914331

PKP4
Plakophilin-4

1

3

High-throughput

0.479

High

914382

HYOU1
Hypoxia up-regulated protein 1

1

3

High-throughput

0.479

High

63647

A5PKU2
TUSC5 protein

1

1

High-throughput

0.470

High

720449

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.458

High

914243

DCD
Dermcidin

1

0

High-throughput

0.458

High

914268

BLTP1
Bridge-like lipid transfer protein family member 1

1

0

High-throughput

0.458

High

914307

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.458

High

914332

DPYL5
Dihydropyrimidinase-related protein 5

1

0

High-throughput

0.458

High

137048

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

6

High-throughput

0.437

High

251871

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

6

High-throughput

0.437

High

300325

KRT34
Keratin, type I cuticular Ha4

1

20

High-throughput

0.437

High

300558

KRT36
Keratin, type I cuticular Ha6

1

19

High-throughput

0.437

High

385072

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.437

High

385252

K2C6A
Keratin, type II cytoskeletal 6A

1

20

High-throughput

0.437

High

407265

K2C6B
Keratin, type II cytoskeletal 6B

1

20

High-throughput

0.437

High

476286

K1C16
Keratin, type I cytoskeletal 16

1

20

High-throughput

0.437

High

550192

PABP1
Polyadenylate-binding protein 1

1

2

High-throughput

0.437

High

566120

K1C10
Keratin, type I cytoskeletal 10

1

20

High-throughput

0.437

High

566348

K2C5
Keratin, type II cytoskeletal 5

1

20

High-throughput

0.437

High

570389

GFAP
Glial fibrillary acidic protein

1

20

High-throughput

0.437

High

650660

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

High-throughput

0.437

High

694998

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

698511

CALX
Calnexin

1

2

High-throughput

0.437

High

716797

RL12
Large ribosomal subunit protein uL11

1

2

High-throughput

0.437

High

771972

K1C9
Keratin, type I cytoskeletal 9

1

20

High-throughput

0.437

High

777430

K22E
Keratin, type II cytoskeletal 2 epidermal

1

20

High-throughput

0.437

High

876455

K2C6C
Keratin, type II cytoskeletal 6C

1

19

High-throughput

0.437

High

914234

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.437

High

914235

RL23
Large ribosomal subunit protein uL14

1

2

High-throughput

0.437

High

914236

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.437

High

914237

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.437

High

914240

KRT83
Keratin, type II cuticular Hb3

1

20

High-throughput

0.437

High

914241

KRT85
Keratin, type II cuticular Hb5

1

20

High-throughput

0.437

High

914246

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.437

High

914256

TBB2A
Tubulin beta-2A chain

1

15

High-throughput

0.437

High

914257

KT33B
Keratin, type I cuticular Ha3-II

1

20

High-throughput

0.437

High

914258

K1H2
Keratin, type I cuticular Ha2

1

20

High-throughput

0.437

High

914263

K1H1
Keratin, type I cuticular Ha1

1

20

High-throughput

0.437

High

914273

MYOME
Myomegalin

1

7

High-throughput

0.437

High

914274

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.437

High

914291

K2C73
Keratin, type II cytoskeletal 73

1

20

High-throughput

0.437

High

914302

GT251
Procollagen galactosyltransferase 1

1

6

High-throughput

0.437

High

914315

KRT35
Keratin, type I cuticular Ha5

1

20

High-throughput

0.437

High

914328

NBPF4
NBPF family member NBPF4

1

1

High-throughput

0.437

High

914336

TMED9
Transmembrane emp24 domain-containing protein 9

1

1

High-throughput

0.437

High

914339

KRA22
Keratin-associated protein 2-2

1

2

High-throughput

0.437

High

914352

KRT82
Keratin, type II cuticular Hb2

1

20

High-throughput

0.437

High

914358

KCTD5
BTB/POZ domain-containing protein KCTD5

1

2

High-throughput

0.437

High

914359

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

1

High-throughput

0.437

High

914365

DJB11
DnaJ homolog subfamily B member 11

1

2

High-throughput

0.437

High

914373

TIM
Protein timeless homolog

1

1

High-throughput

0.437

High

212560

GPAA1
GPI-anchor transamidase component GPAA1

1

0

High-throughput

0.279

Low

244340

NPA1P
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.279

Low

253749

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.279

Low

301376

WFS1
Wolframin

1

0

High-throughput

0.279

Low

319553

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.279

Low

325476

CCNB2
G2/mitotic-specific cyclin-B2

1

0

High-throughput

0.279

Low

841115

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.279

Low

914228

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.279

Low

914244

COG7
Conserved oligomeric Golgi complex subunit 7

1

0

High-throughput

0.279

Low

914250

WASC5
WASH complex subunit 5

1

0

High-throughput

0.279

Low

914252

TARB1
tRNA

1

0

High-throughput

0.279

Low

914253

MTX1
Metaxin-1

1

0

High-throughput

0.279

Low

914259

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.279

Low

914260

SPCS2
Signal peptidase complex subunit 2

1

0

High-throughput

0.279

Low

914265

NR6A1
Nuclear receptor subfamily 6 group A member 1

1

0

High-throughput

0.279

Low

914272

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.279

Low

914275

RINT1
RAD50-interacting protein 1

1

0

High-throughput

0.279

Low

914276

TM214
Transmembrane protein 214

1

0

High-throughput

0.279

Low

914277

TTI2
TELO2-interacting protein 2

1

0

High-throughput

0.279

Low

914279

MZT2B
Mitotic-spindle organizing protein 2B

1

0

High-throughput

0.279

Low

914280

EDC4
Enhancer of mRNA-decapping protein 4

1

0

High-throughput

0.279

Low

914281

INT5
Integrator complex subunit 5

1

0

High-throughput

0.279

Low

914289

TEDC1
Tubulin epsilon and delta complex protein 1

1

0

High-throughput

0.279

Low

914297

INT1
Integrator complex subunit 1

1

0

High-throughput

0.279

Low

914299

KDM8
Bifunctional peptidase and arginyl-hydroxylase JMJD5

1

0

High-throughput

0.279

Low

914304

SPC24
Kinetochore protein Spc24

1

0

High-throughput

0.279

Low

914306

DMXL2
DmX-like protein 2

1

0

High-throughput

0.279

Low

914308

COG1
Conserved oligomeric Golgi complex subunit 1

1

0

High-throughput

0.279

Low

914311

ATRIP
ATR-interacting protein

1

0

High-throughput

0.279

Low

914314

CENPI
Centromere protein I

1

0

High-throughput

0.279

Low

914317

GLMN
Glomulin

1

0

High-throughput

0.279

Low

914318

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.279

Low

914320

RUND1
RUN domain-containing protein 1

1

0

High-throughput

0.279

Low

914321

INT12
Integrator complex subunit 12

1

0

High-throughput

0.279

Low

914326

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.279

Low

914334

CENPK
Centromere protein K

1

0

High-throughput

0.279

Low

914335

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.279

Low

914338

B2L13
Bcl-2-like protein 13

1

0

High-throughput

0.279

Low

914341

INT2
Integrator complex subunit 2

1

0

High-throughput

0.279

Low

914342

TM245
Transmembrane protein 245

1

0

High-throughput

0.279

Low

914343

CENPH
Centromere protein H

1

0

High-throughput

0.279

Low

914345

ZWILC
Protein zwilch homolog

1

0

High-throughput

0.279

Low

914346

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.279

Low

914349

SPC25
Kinetochore protein Spc25

1

0

High-throughput

0.279

Low

914350

K1586
E3 SUMO-protein ligase KIAA1586

1

0

High-throughput

0.279

Low

914356

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.279

Low

914360

VPS54
Vacuolar protein sorting-associated protein 54

1

0

High-throughput

0.279

Low

914363

HTR5B
HEAT repeat-containing protein 5B

1

0

High-throughput

0.279

Low

914366

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

0

High-throughput

0.279

Low

914368

CS025
UPF0449 protein C19orf25

1

0

High-throughput

0.279

Low

914372

TPC1
Two pore channel protein 1

1

0

High-throughput

0.279

Low

914375

COG5
Conserved oligomeric Golgi complex subunit 5

1

0

High-throughput

0.279

Low

914377

PLAP
Phospholipase A-2-activating protein

1

0

High-throughput

0.279

Low

914378

UST
Uronyl 2-sulfotransferase

1

0

High-throughput

0.279

Low

914379

COG6
Conserved oligomeric Golgi complex subunit 6

1

0

High-throughput

0.279

Low

914380

NOP58
Nucleolar protein 58

1

0

High-throughput

0.279

Low

914381

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

High-throughput

0.279

Low

914384

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

276088

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.249

Low

346918

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.249

Low

415451

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.249

Low

591550

H2AX
Histone H2AX

1

0

High-throughput

0.249

Low

595716

H13
Histone H1.3

1

0

High-throughput

0.249

Low

770111

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.249

Low

809541

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.249

Low

914231

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.249

Low

914233

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.249

Low

914266

PROL4
Proline-rich protein 4

1

0

High-throughput

0.249

Low

914269

ZN699
Zinc finger protein 699

1

0

High-throughput

0.249

Low

914271

DMRTC
Doublesex- and mab-3-related transcription factor C1

1

0

High-throughput

0.249

Low

914278

H3C
Histone H3.3C

1

0

High-throughput

0.249

Low

914298

ELMD1
ELMO domain-containing protein 1

1

0

High-throughput

0.249

Low

914301

MARHA
Probable E3 ubiquitin-protein ligase MARCHF10

1

0

High-throughput

0.249

Low

914333

PSF3
DNA replication complex GINS protein PSF3

1

0

High-throughput

0.249

Low

914344

SFR19
Splicing factor, arginine/serine-rich 19

1

0

High-throughput

0.249

Low

914348

BEX1
Protein BEX1

1

0

High-throughput

0.249

Low

914351

DPOLM
DNA-directed DNA/RNA polymerase mu

1

0

High-throughput

0.249

Low

914354

ACOXL
Acyl-coenzyme A oxidase-like protein

1

0

High-throughput

0.249

Low

914362

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025