HitPredict

Interactor 1: CDC16 (Q13042)
Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6)
Gene: CDC16

Interactor 2: TTC8 (Q8TAM2)
Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein)
Gene: TTC8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ANAPC3~TPR_8, TPR_12~TPR_8
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 620 Hs			1 541
+	Hs
		672822 CDC16_HUMAN (1-620): 1.68e-124: 382: 100.00		CDC27_HUMAN (177-489): 2.34e-35: 143: 9.84
+	Xl
		1150241 Q6DFI7_XENLA (1-620): 1.03e-120: 372: 88.60		Q6GQ04_XENLA (64-493): 1.87e-33: 137: 12.70
+	Sc
		454909 CDC16_YEAST (3-581): 1.58e-77: 265: 30.17		CDC27_YEAST (196-399): 1.09e-22: 104: 12.62
+	Sc
		561118 CDC23_YEAST (30-501): 5.8e-73: 248: 15.39		CDC27_YEAST (196-399): 1.09e-22: 104: 12.62
+	At
		71745 APC7_ARATH (14-553): 1.82e-64: 223: 14.26		CDC16_ARATH (196-470): 1.78e-25: 112: 14.24
+	Hs
		174451 OGT1_HUMAN (371-616): 3.19e-26: 116: 16.67		OGT1_HUMAN (7-492): 6.79e-60: 215: 16.60
+	Sp
		489650 CUT9_SCHPO (3-598): 2.2e-72: 247: 31.33		APC3_SCHPO (346-540): 3.92e-13: 74.1: 14.21
+	Hs
		175291 APC7_HUMAN (75-607): 2.88e-19: 93.7: 12.73		OGT1_HUMAN (7-492): 6.79e-60: 215: 16.60
+	Dm
		1363028 Q9VCN6_DROME (1-599): 7.82e-45: 171: 20.18		Q9VS37_DROME (18-455): 4.72e-31: 130: 14.81
+	Sc
		743211 CDC27_YEAST (234-522): 1.52e-44: 171: 18.49		CDC27_YEAST (196-399): 1.09e-22: 104: 12.62
+	Mm
		56872 APC7_MOUSE (75-607): 9.31e-19: 92.2: 12.55		CDC27_MOUSE (199-533): 2.28e-48: 181: 15.04
+	Hs
		1024250 IFT88_HUMAN (1-433): 1.35e-35: 145: 9.27		IFT88_HUMAN (155-458): 1.02e-22: 104: 13.03
+	Hs
		672917 APC7_HUMAN (75-607): 2.88e-19: 93.7: 12.73		CDC27_HUMAN (177-489): 2.34e-35: 143: 9.84
+	Xl
		1150214 Q6DDX5_XENLA (75-607): 7.74e-19: 92.2: 13.11		Q6GQ04_XENLA (64-493): 1.87e-33: 137: 12.70
+	Hs
		672916 CDC23_HUMAN (9-383): 2.3e-15: 81.4: 9.71		CDC27_HUMAN (177-489): 2.34e-35: 143: 9.84
+	Hs
		672772 CDC27_HUMAN (4-194): 3.68e-15: 81: 17.80		CDC27_HUMAN (177-489): 2.34e-35: 143: 9.84
+	Xl
		1151584 Q7T0N9_XENLA (9-385): 1.08e-16: 85.6: 10.76		Q6GQ04_XENLA (64-493): 1.87e-33: 137: 12.70
+	Xl
		1151586 Q8AVF0_XENLA (9-336): 1.36e-15: 81.7: 10.35		Q6GQ04_XENLA (64-493): 1.87e-33: 137: 12.70
+	Sp
		489649 APC3_SCHPO (4-578): 2.69e-33: 137: 12.04		APC3_SCHPO (346-540): 3.92e-13: 74.1: 14.21
+	Sc
		542092 CYC8_YEAST (445-611): 4.83e-15: 81: 11.98		CYC8_YEAST (452-541): 2.42e-09: 62.2: 14.44