Protein: EFNB2
Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L)

Gene: EFNB2
Organism: Homo sapiens
Interactions: 181
UniProt ID: P52799

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0001945 - lymph vessel development
GO:0002042 - cell migration involved in sprouting angiogenesis
GO:0005886 - plasma membrane
GO:0005912 - adherens junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

914388

EPHB4
Ephrin type-B receptor 4

6

20

Small-scale

0.949

High

710796

EPHB2
Ephrin type-B receptor 2

6

20

Small-scale

0.944

High

914386

EPHB3
Ephrin type-B receptor 3

4

20

High-throughput

0.892

High

914387

EPHA5
Ephrin type-A receptor 5

4

20

High-throughput

0.892

High

914407

EFNB1
Ephrin-B1

4

5

High-throughput

0.892

High

710610

EPHA3
Ephrin type-A receptor 3

2

20

Small-scale

0.778

High

914389

EPHA4
Ephrin type-A receptor 4

1

20

Small-scale

0.761

High

136344

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

3

9

High-throughput

0.667

High

247266

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

3

1

High-throughput

0.667

High

714598

TYK2
Non-receptor tyrosine-protein kinase TYK2

3

7

High-throughput

0.667

High

839140

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

3

5

High-throughput

0.667

High

914413

MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1

3

5

High-throughput

0.667

High

914415

DIP2A
Disco-interacting protein 2 homolog A

3

3

High-throughput

0.667

High

914417

KIF14
Kinesin-like protein KIF14

3

2

High-throughput

0.667

High

914426

PKHG4
Puratrophin-1

3

1

High-throughput

0.667

High

914456

P4K2B
Phosphatidylinositol 4-kinase type 2-beta

3

1

High-throughput

0.667

High

914496

DIP2B
Disco-interacting protein 2 homolog B

3

3

High-throughput

0.667

High

914506

DYN3
Dynamin-3

3

6

High-throughput

0.667

High

914408

AT2B2
Plasma membrane calcium-transporting ATPase 2

3

0

High-throughput

0.638

High

914459

LMBR1
Limb region 1 protein homolog

3

0

High-throughput

0.638

High

252669

TSN3
Tetraspanin-3

2

3

High-throughput

0.628

High

890642

RGS3
Regulator of G-protein signaling 3

2

4

High-throughput

0.628

High

710135

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

760416

SDC2
Syndecan-2

2

3

High-throughput

0.611

High

838969

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

2

5

High-throughput

0.611

High

914473

PKP2
Plakophilin-2

2

3

High-throughput

0.611

High

914485

PICK1
PRKCA-binding protein

2

2

High-throughput

0.611

High

71303

F1712
Protein FAM171A2

3

2

High-throughput

0.609

High

255777

USO1
General vesicular transport factor p115

3

4

High-throughput

0.609

High

273178

CAND2
Cullin-associated NEDD8-dissociated protein 2

3

6

High-throughput

0.609

High

331726

MTMR5
Myotubularin-related protein 5

3

5

High-throughput

0.609

High

890105

EI2BB
Translation initiation factor eIF2B subunit beta

3

5

High-throughput

0.609

High

914425

TIGD5
Tigger transposable element-derived protein 5

3

1

High-throughput

0.609

High

914433

PKN3
Serine/threonine-protein kinase N3

3

3

High-throughput

0.609

High

914439

PKHH3
Pleckstrin homology domain-containing family H member 3

3

1

High-throughput

0.609

High

914446

DEN6A
Protein DENND6A

3

2

High-throughput

0.609

High

914471

MA7D2
MAP7 domain-containing protein 2

3

4

High-throughput

0.609

High

870637

MAOX
NADP-dependent malic enzyme

3

1

High-throughput

0.593

High

375317

RASK
GTPase KRas

2

14

High-throughput

0.584

High

914400

ARF6
ADP-ribosylation factor 6

2

1

High-throughput

0.584

High

637868

NF1
Neurofibromin

2

4

High-throughput

0.571

High

222041

NCK2
Cytoplasmic protein NCK2

2

12

Small-scale

0.570

High

914469

RADIL
Ras-associating and dilute domain-containing protein

2

6

High-throughput

0.558

High

914500

EI2BD
Translation initiation factor eIF2B subunit delta

2

5

High-throughput

0.558

High

914441

ANR46
Ankyrin repeat domain-containing protein 46

2

3

High-throughput

0.553

High

269913

SDC3
Syndecan-3

1

4

High-throughput

0.536

High

532165

CD28
T-cell-specific surface glycoprotein CD28

1

1

High-throughput

0.536

High

914450

S39AB
Zinc transporter ZIP11

1

3

High-throughput

0.536

High

914412

EI2BE
Translation initiation factor eIF2B subunit epsilon

2

6

High-throughput

0.521

High

914419

UBE3C
Ubiquitin-protein ligase E3C

2

2

High-throughput

0.521

High

914405

RELN
Reelin

1

4

Small-scale

0.501

High

189474

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

341008

DIRA3
GTP-binding protein Di-Ras3

1

3

High-throughput

0.479

High

373853

RASN
GTPase NRas

1

14

High-throughput

0.479

High

374489

RASH
GTPase HRas

1

10

High-throughput

0.479

High

440005

LCK
Tyrosine-protein kinase Lck

1

5

High-throughput

0.479

High

463415

LYN
Tyrosine-protein kinase Lyn

1

5

High-throughput

0.479

High

540372

LAMP1
Lysosome-associated membrane glycoprotein 1

1

5

High-throughput

0.479

High

561963

LAMP2
Lysosome-associated membrane glycoprotein 2

1

5

High-throughput

0.479

High

582723

EZRI
Ezrin

1

3

High-throughput

0.479

High

601218

RHOQ
Rho-related GTP-binding protein RhoQ

1

17

High-throughput

0.479

High

603903

CXA1
Gap junction alpha-1 protein

1

7

High-throughput

0.479

High

631136

RAB5A
Ras-related protein Rab-5A

1

5

High-throughput

0.479

High

699659

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

6

High-throughput

0.479

High

715499

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

767406

RADI
Radixin

1

2

High-throughput

0.479

High

900738

RAB5C
Ras-related protein Rab-5C

1

5

High-throughput

0.479

High

914391

AFAD
Afadin

1

8

High-throughput

0.479

High

914392

ARL4C
ADP-ribosylation factor-like protein 4C

1

7

High-throughput

0.479

High

914394

RAC3
Ras-related C3 botulinum toxin substrate 3

1

15

High-throughput

0.479

High

914395

CDC42
Cell division control protein 42 homolog

1

16

High-throughput

0.479

High

914397

RHOA
Transforming protein RhoA

1

14

High-throughput

0.479

High

914398

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

914401

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

914402

RHOB
Rho-related GTP-binding protein RhoB

1

16

High-throughput

0.479

High

914403

RAC1
Ras-related C3 botulinum toxin substrate 1

1

15

High-throughput

0.479

High

914404

CXAR
Coxsackievirus and adenovirus receptor

1

3

High-throughput

0.479

High

914409

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

914411

STX4
Syntaxin-4

1

3

High-throughput

0.479

High

914418

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.479

High

914420

RHOH
Rho-related GTP-binding protein RhoH

1

17

High-throughput

0.479

High

914421

OCLN
Occludin

1

1

High-throughput

0.479

High

914429

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

914434

RHDF2
Inactive rhomboid protein 2

1

2

High-throughput

0.479

High

914449

CXD3
Gap junction delta-3 protein

1

7

High-throughput

0.479

High

914451

ARL14
ADP-ribosylation factor-like protein 14

1

3

High-throughput

0.479

High

914458

PARD3
Partitioning defective 3 homolog

1

5

High-throughput

0.479

High

914460

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

9

High-throughput

0.479

High

914477

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.479

High

914478

RHOJ
Rho-related GTP-binding protein RhoJ

1

17

High-throughput

0.479

High

914480

RHOF
Rho-related GTP-binding protein RhoF

1

18

High-throughput

0.479

High

914493

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

1

High-throughput

0.479

High

914507

LAMP3
Lysosome-associated membrane glycoprotein 3

1

5

High-throughput

0.479

High

225972

STX6
Syntaxin-6

1

0

High-throughput

0.458

High

914490

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

Small-scale

0.458

High

914502

UBQL1
Ubiquilin-1

1

0

High-throughput

0.458

High

65340

TCAF2
TRPM8 channel-associated factor 2

1

1

High-throughput

0.445

High

484085

PGFRB
Platelet-derived growth factor receptor beta

1

16

High-throughput

0.445

High

616731

SDC1
Syndecan-1

1

3

High-throughput

0.445

High

726645

SDC4
Syndecan-4

1

2

High-throughput

0.445

High

839442

PI4KA
Phosphatidylinositol 4-kinase alpha

1

4

High-throughput

0.445

High

914390

S12A2
Solute carrier family 12 member 2

1

1

High-throughput

0.445

High

914410

ATP7A
Copper-transporting ATPase 1

1

2

High-throughput

0.445

High

914414

EI2BA
Translation initiation factor eIF2B subunit alpha

1

5

High-throughput

0.445

High

914427

F1711
Protein FAM171A1

1

2

High-throughput

0.445

High

914430

TEN4
Teneurin-4

1

5

High-throughput

0.445

High

914432

S39A4
Zinc transporter ZIP4

1

3

High-throughput

0.445

High

914479

EVA1A
Protein eva-1 homolog A

1

1

High-throughput

0.445

High

914487

TEN2
Teneurin-2

1

5

High-throughput

0.445

High

914494

SACS
Sacsin

1

1

High-throughput

0.445

High

914497

TEN3
Teneurin-3

1

5

High-throughput

0.445

High

914499

S53A1
Solute carrier family 53 member 1

1

1

High-throughput

0.445

High

914503

PCDB8
Protocadherin beta-8

1

8

High-throughput

0.445

High

914504

PCDGK
Protocadherin gamma-C3

1

6

High-throughput

0.445

High

914505

PCDGG
Protocadherin gamma-B4

1

9

High-throughput

0.445

High

914509

PLXD1
Plexin-D1

1

1

High-throughput

0.445

High

914510

PCDB2
Protocadherin beta-2

1

8

High-throughput

0.445

High

914511

PCDBE
Protocadherin beta-14

1

8

High-throughput

0.445

High

914512

PCDBC
Protocadherin beta-12

1

8

High-throughput

0.445

High

914513

PCDBB
Protocadherin beta-11

1

8

High-throughput

0.445

High

914514

PCDGH
Protocadherin gamma-B5

1

9

High-throughput

0.445

High

914515

PCDGD
Protocadherin gamma-B1

1

9

High-throughput

0.445

High

914517

ROBO1
Roundabout homolog 1

1

1

High-throughput

0.445

High

177526

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

1

High-throughput

0.437

High

327204

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.437

High

790879

TAGL2
Transgelin-2

1

1

High-throughput

0.437

High

914396

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.437

High

914422

AR13B
ADP-ribosylation factor-like protein 13B

1

2

High-throughput

0.437

High

914442

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

914445

MA7D3
MAP7 domain-containing protein 3

1

3

High-throughput

0.437

High

914452

EFNMT
eEF1A lysine and N-terminal methyltransferase

1

1

High-throughput

0.437

High

914462

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

914465

SAAL1
Protein SAAL1

1

1

High-throughput

0.437

High

914491

ARL15
ADP-ribosylation factor-like protein 15

1

4

High-throughput

0.437

High

914495

TM216
Transmembrane protein 216

1

1

High-throughput

0.437

High

914498

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.437

High

914516

ARL5A
ADP-ribosylation factor-like protein 5A

1

3

High-throughput

0.437

High

914443

IPRI
Inositol 1,4,5-trisphosphate receptor-interacting protein

1

0

High-throughput

0.426

High

914466

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.426

High

914488

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.426

High

914416

CUL7
Cullin-7

1

1

High-throughput

0.407

High

914424

RHG29
Rho GTPase-activating protein 29

1

2

High-throughput

0.407

High

914428

RN213
E3 ubiquitin-protein ligase RNF213

1

1

High-throughput

0.407

High

914436

THADA
tRNA

1

2

High-throughput

0.407

High

914438

HEAT3
HEAT repeat-containing protein 3

1

2

High-throughput

0.407

High

914440

AACS
Acetoacetyl-CoA synthetase

1

1

High-throughput

0.407

High

914447

CUL9
Cullin-9

1

1

High-throughput

0.407

High

914455

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

2

High-throughput

0.407

High

914470

PCD16
Protocadherin-16

1

4

High-throughput

0.407

High

914472

RUFY1
RUN and FYVE domain-containing protein 1

1

6

High-throughput

0.407

High

914475

RAB34
Ras-related protein Rab-34

1

4

High-throughput

0.407

High

914481

CWC22
Pre-mRNA-splicing factor CWC22 homolog

1

1

High-throughput

0.407

High

914483

AT132
Polyamine-transporting ATPase 13A2

1

4

High-throughput

0.407

High

914484

EI2BG
Translation initiation factor eIF2B subunit gamma

1

3

High-throughput

0.407

High

914489

MDN1
Midasin

1

1

High-throughput

0.407

High

914492

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

1

High-throughput

0.407

High

914501

KDIS
Kinase D-interacting substrate of 220 kDa

1

1

High-throughput

0.407

High

914476

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

3

0

High-throughput

0.347

High

914464

NGBR
Dehydrodolichyl diphosphate synthase complex subunit NUS1

2

0

High-throughput

0.328

High

914444

TEX2
Testis-expressed protein 2

2

0

High-throughput

0.313

High

914448

PLPL6
Patatin-like phospholipase domain-containing protein 6

2

0

High-throughput

0.313

High

914486

AAAS
Aladin

2

0

High-throughput

0.298

High

914508

MED16
Mediator of RNA polymerase II transcription subunit 16

2

0

High-throughput

0.298

High

417338

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.279

Low

914482

TM9S3
Transmembrane 9 superfamily member 3

1

0

High-throughput

0.279

Low

914463

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.269

Low

139832

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

914393

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.249

Low

914399

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.249

Low

914431

RETST
All-trans-retinol 13,14-reductase

1

0

High-throughput

0.249

Low

914461

HPS3
BLOC-2 complex member HPS3

1

0

High-throughput

0.249

Low

914467

P121A
Nuclear envelope pore membrane protein POM 121

1

0

High-throughput

0.249

Low

914406

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.232

Low

914423

RIC1
Guanine nucleotide exchange factor subunit RIC1

1

0

High-throughput

0.232

Low

914435

SBSN
Suprabasin

1

0

High-throughput

0.232

Low

914437

DPH6
Diphthine--ammonia ligase

1

0

High-throughput

0.232

Low

914453

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

0

High-throughput

0.232

Low

914454

MROH1
Maestro heat-like repeat-containing protein family member 1

1

0

High-throughput

0.232

Low

914457

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.232

Low

914468

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.232

Low

914474

HGH1
Protein HGH1 homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025