HitPredict

Interactor 1: STK4 (Q13043)
Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
Gene: STK4

Interactor 2: STK3 (Q13188)
Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]
Gene: STK3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.979

The method score is based on:

Property Details
Experiments 24366813, 24981860, 35271311, 20562859, 24255178, 23455922, 28205554, 32707033, 20920251, 23386615
Identification Methods affinity chromatography technology, proximity labelling technology, fluorescent resonance energy transfer, pull down, two hybrid, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Mst1_SARAH~Mst1_SARAH, Pkinase~Pkinase
Common GO terms GO:0000287 - magnesium ion binding
GO:0001841 - neural tube formation
GO:0003157 - endocardium development
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
and 31 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 487
Hs

1 491
+ Hs
+ Hs
+ Hs
+ Hs
+ Gm
+ At
+ At
+ At
+ At
+ Hs
+ At
+ At
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024