HitPredict

Interactor 1: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	25996949, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 416 Hs			1 729
+	Mm
		761845 TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77		TBK1_MOUSE (1-729): 0: 558: 94.10
+	Hs
		1020970 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		158457 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		1355374 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		167532 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		1020655 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		158456 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		1050311 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		167531 TRAF2_HUMAN (3-415): 4e-124: 370: 38.01		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		158575 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Rn
		78184 TRAF6_RAT (15-414): 4.07e-99: 307: 22.08		IKKB_RAT (9-708): 1.99e-139: 429: 19.46
+	Hs
		167639 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		129603 TRAF5_HUMAN (14-261): 1.36e-16: 83.8: 13.91		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		1024780 TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Mm
		1141450 TRAF3_MOUSE (1-262): 2.34e-12: 70.7: 16.37		TBK1_MOUSE (1-729): 0: 558: 94.10
+	Hs
		1024675 TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		167608 TRAF4_HUMAN (27-136): 3.55e-09: 60.3: 17.86		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		262332 TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Hs
		262260 TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10