HitPredict

Interactor 1: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Interactor 2: TNR11 (Q9Y6Q6)
Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265)
Gene: TNFRSF11A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	9852070, 10025951, 9774460
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 416 Hs			1 616
+	Mm
		192583 TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77		TNR11_MOUSE (1-615): 0: 833: 67.20
+	Hs
		639577 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		TNR5_HUMAN (11-227): 5.79e-69: 226: 36.07
+	Hs
		738660 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		TNR3_HUMAN (1-208): 4.39e-57: 200: 26.01
+	Hs
		591319 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		TNR1B_HUMAN (1-213): 2.29e-52: 188: 31.86
+	Hs
		1023745 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		TNR14_HUMAN (7-190): 2.49e-51: 180: 29.10
+	Hs
		584392 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		TNR1A_HUMAN (33-236): 3.5e-47: 173: 21.91
+	Hs
		436619 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		TNR16_HUMAN (25-212): 8.51e-42: 158: 23.96
+	Hs
		796824 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		TNR4_HUMAN (29-217): 5.17e-39: 146: 26.46
+	Hs
		1023845 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		TNR18_HUMAN (86-233): 2.45e-37: 140: 24.16
+	Hs
		989743 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		TNR9_HUMAN (47-227): 1.18e-34: 133: 25.93
+	Hs
		1023749 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		TR19L_HUMAN (49-238): 1.94e-31: 129: 17.80
+	Mm
		761775 TRAF1_MOUSE (1-416): 4.49e-160: 458: 84.38		TNR4_MOUSE (34-217): 5.48e-43: 157: 24.46
+	Mm
		648951 TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77		TNR5_MOUSE (11-226): 6.73e-70: 229: 33.03
+	Hs
		661044 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		TNR8_HUMAN (30-192): 6.05e-25: 111: 25.00
+	Hs
		645796 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		CD27_HUMAN (17-130): 6.72e-26: 109: 26.27
+	Hs
		1023803 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		TNR27_HUMAN (33-153): 6.46e-25: 107: 23.88
+	Hs
		1023815 TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00		TNR19_HUMAN (13-165): 1.33e-23: 105: 20.00
+	Mm
		591444 TRAF1_MOUSE (1-416): 4.49e-160: 458: 84.38		TNR9_MOUSE (45-211): 4.13e-32: 126: 27.98
+	Mm
		626852 TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77		TNR1A_MOUSE (33-192): 7.97e-42: 159: 23.49
+	Mm
		591445 TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77		TNR9_MOUSE (45-211): 4.13e-32: 126: 27.98