Protein: 2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (B55) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha)

Gene: 2ABA, PPP2R2A
Organism: Homo sapiens
Interactions: 240
UniProt ID: P63151

Gene Ontology (top 5):
GO:0000159 - protein phosphatase type 2A complex
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006470 - protein dephosphorylation
GO:0019888 - protein phosphatase regulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

717763

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

18

10

Small-scale

0.766

High

991006

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

12

20

Small-scale

0.762

High

977455

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

8

20

High-throughput

0.756

High

718099

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

6

10

Small-scale

0.737

High

991046

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

5

7

High-throughput

0.720

High

58719

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

5

7

High-throughput

0.716

High

991095

CDCA4
Cell division cycle-associated protein 4

4

9

High-throughput

0.702

High

991079

PBIR1
PPP2R1A-PPP2R2A-interacting phosphatase regulator 1

4

7

High-throughput

0.699

High

991092

IER2
Immediate early response gene 2 protein

3

8

High-throughput

0.667

High

991135

RBM7
RNA-binding protein 7

3

8

High-throughput

0.657

High

563588

CFTR
Cystic fibrosis transmembrane conductance regulator

3

2

High-throughput

0.650

High

991134

PPME1
Protein phosphatase methylesterase 1

3

2

Small-scale

0.650

High

991107

SRTD4
SERTA domain-containing protein 4

4

3

High-throughput

0.638

High

991017

FOXC1
Forkhead box protein C1

2

15

High-throughput

0.628

High

991091

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

2

2

High-throughput

0.628

High

838694

MTREX
Exosome RNA helicase MTR4

2

5

High-throughput

0.621

High

920422

DAPK1
Death-associated protein kinase 1

2

1

Small-scale

0.620

High

991023

CUL3
Cullin-3

2

4

High-throughput

0.611

High

991063

FXL16
F-box/LRR-repeat protein 16

2

4

Small-scale

0.611

High

991070

COP1
E3 ubiquitin-protein ligase COP1

2

3

High-throughput

0.611

High

991090

FOXC2
Forkhead box protein C2

2

15

Small-scale

0.611

High

991124

HDAC5
Histone deacetylase 5

2

7

High-throughput

0.611

High

991018

FOXD4
Forkhead box protein D4

3

13

High-throughput

0.604

High

241345

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

315427

RECQ4
ATP-dependent DNA helicase Q4

2

5

High-throughput

0.584

High

536930

HSP7C
Heat shock cognate 71 kDa protein

2

1

High-throughput

0.584

High

658587

KS6B1
Ribosomal protein S6 kinase beta-1

2

5

Small-scale

0.584

High

991025

EIF3A
Eukaryotic translation initiation factor 3 subunit A

2

2

High-throughput

0.584

High

991098

SIK2
Serine/threonine-protein kinase SIK2

3

7

Small-scale

0.578

High

991054

TAFA3
Chemokine-like protein TAFA-3

2

1

High-throughput

0.574

High

400623

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

5

High-throughput

0.571

High

711299

SHC1
SHC-transforming protein 1

2

3

High-throughput

0.571

High

955040

CDC42
Cell division control protein 42 homolog

2

2

High-throughput

0.571

High

991019

GRB10
Growth factor receptor-bound protein 10

2

5

High-throughput

0.571

High

991041

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

Small-scale

0.563

High

578448

BRAF
Serine/threonine-protein kinase B-raf

1

5

Small-scale

0.561

High

787377

TGFR1
TGF-beta receptor type-1

1

4

Small-scale

0.561

High

991128

AMOL2
Angiomotin-like protein 2

1

3

Small-scale

0.561

High

259764

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.559

High

920780

ACLY
ATP-citrate synthase

1

3

High-throughput

0.554

High

973386

RS11
Small ribosomal subunit protein uS17

1

2

High-throughput

0.554

High

991049

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

3

High-throughput

0.554

High

991061

CCAR2
Cell cycle and apoptosis regulator protein 2

1

2

High-throughput

0.554

High

908195

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

0

High-throughput

0.547

High

991131

NOSIP
Nitric oxide synthase-interacting protein

1

0

Small-scale

0.537

High

226970

ENSA
Alpha-endosulfine

1

3

High-throughput

0.536

High

247282

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

1

High-throughput

0.536

High

390282

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.536

High

424174

S10A8
Protein S100-A8

1

6

High-throughput

0.536

High

444950

S10A9
Protein S100-A9

1

9

High-throughput

0.536

High

503568

TFPT
TCF3 fusion partner

1

1

High-throughput

0.536

High

724556

S10A7
Protein S100-A7

1

9

High-throughput

0.536

High

841151

CNDD3
Condensin-2 complex subunit D3

1

4

High-throughput

0.536

High

849137

KSYK
Tyrosine-protein kinase SYK

1

5

High-throughput

0.536

High

929774

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

951956

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

19

High-throughput

0.536

High

991010

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

7

High-throughput

0.536

High

991011

CDK16
Cyclin-dependent kinase 16

1

6

High-throughput

0.536

High

991024

SRTD2
SERTA domain-containing protein 2

1

7

High-throughput

0.536

High

991044

IER5
Immediate early response gene 5 protein

1

8

High-throughput

0.536

High

991097

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

1

High-throughput

0.536

High

991129

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

1

7

High-throughput

0.536

High

991132

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

2

High-throughput

0.536

High

857405

NOTC1
Neurogenic locus notch homolog protein 1

1

0

High-throughput

0.530

High

487177

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.515

High

991075

NDRG1
Protein NDRG1

1

3

Small-scale

0.515

High

421889

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

991031

NEDD8
Ubiquitin-like protein NEDD8

1

1

High-throughput

0.515

High

142522

IMA3
Importin subunit alpha-3

1

0

High-throughput

0.513

High

221031

HAIR
Lysine-specific demethylase hairless

1

0

High-throughput

0.513

High

572802

NCF1
Neutrophil cytosol factor 1

1

0

High-throughput

0.513

High

973131

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.513

High

983259

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.513

High

991103

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

0

High-throughput

0.513

High

839236

MTOR
Serine/threonine-protein kinase mTOR

1

4

Small-scale

0.501

High

176816

DCLK1
Serine/threonine-protein kinase DCLK1

1

1

High-throughput

0.489

High

221931

FOXS1
Forkhead box protein S1

1

15

High-throughput

0.489

High

665964

IBP5
Insulin-like growth factor-binding protein 5

1

3

High-throughput

0.489

High

991012

CDK17
Cyclin-dependent kinase 17

1

6

High-throughput

0.489

High

991037

FX4L6
Forkhead box protein D4-like 6

1

15

High-throughput

0.489

High

991071

DUS19
Dual specificity protein phosphatase 19

1

2

High-throughput

0.489

High

991082

ZN414
Zinc finger protein 414

1

1

High-throughput

0.489

High

991094

RFIP5
Rab11 family-interacting protein 5

1

3

High-throughput

0.489

High

991119

SRTD1
SERTA domain-containing protein 1

1

1

High-throughput

0.489

High

991123

TRI35
E3 ubiquitin-protein ligase TRIM35

1

1

High-throughput

0.489

High

991126

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

9

High-throughput

0.489

High

991133

CCDC9
Coiled-coil domain-containing protein 9

1

1

High-throughput

0.489

High

991112

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

1

0

Small-scale

0.480

High

339715

KLF8
Krueppel-like factor 8

1

0

High-throughput

0.479

High

131930

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

Small-scale

0.479

High

142927

NFIB
Nuclear factor 1 B-type

1

1

High-throughput

0.479

High

170065

AURKA
Aurora kinase A

1

3

High-throughput

0.479

High

172680

XPO1
Exportin-1

1

5

High-throughput

0.479

High

193543

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

3

High-throughput

0.479

High

208496

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

Small-scale

0.479

High

218042

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

285199

EED
Polycomb protein EED

1

1

High-throughput

0.479

High

345644

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

349933

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

363109

EGFR
Epidermal growth factor receptor

1

5

High-throughput

0.479

High

370624

FOS
Protein c-Fos

1

6

High-throughput

0.479

High

395861

ESR1
Estrogen receptor

1

2

High-throughput

0.479

High

408797

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

High-throughput

0.479

High

473904

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.479

High

517459

GLI2
Zinc finger protein GLI2

1

2

High-throughput

0.479

High

519925

ANDR
Androgen receptor

1

2

Small-scale

0.479

High

588432

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

610609

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.479

High

692039

MARK3
MAP/microtubule affinity-regulating kinase 3

1

7

Small-scale

0.479

High

702922

DPOD1
DNA polymerase delta catalytic subunit

1

2

High-throughput

0.479

High

719308

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

761976

GRK5
G protein-coupled receptor kinase 5

1

3

High-throughput

0.479

High

767044

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

2

High-throughput

0.479

High

821298

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.479

High

827372

MLH1
DNA mismatch repair protein Mlh1

1

2

High-throughput

0.479

High

830527

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

875906

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.479

High

881868

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.479

High

883212

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

887943

MCM2
DNA replication licensing factor MCM2

1

11

High-throughput

0.479

High

898987

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.479

High

899335

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.479

High

919873

PLK1
Serine/threonine-protein kinase PLK1

1

4

High-throughput

0.479

High

957309

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

959123

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

970285

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

991007

TBA4A
Tubulin alpha-4A chain

1

3

High-throughput

0.479

High

991008

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.479

High

991013

FABP5
Fatty acid-binding protein 5

1

1

High-throughput

0.479

High

991014

DSG1
Desmoglein-1

1

2

High-throughput

0.479

High

991015

ACK1
Activated CDC42 kinase 1

1

3

High-throughput

0.479

High

991026

RBM39
RNA-binding protein 39

1

5

High-throughput

0.479

High

991028

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

991029

TCAL1
Transcription elongation factor A protein-like 1

1

2

High-throughput

0.479

High

991030

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

1

Small-scale

0.479

High

991032

RBBP7
Histone-binding protein RBBP7

1

1

High-throughput

0.479

High

991033

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

991034

SMU1
WD40 repeat-containing protein SMU1

1

1

High-throughput

0.479

High

991038

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

991040

DCA10
DDB1- and CUL4-associated factor 10

1

4

High-throughput

0.479

High

991047

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

991055

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

991059

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.479

High

991060

AHI1
Jouberin

1

6

High-throughput

0.479

High

991062

FBXW8
F-box/WD repeat-containing protein 8

1

2

High-throughput

0.479

High

991065

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

Small-scale

0.479

High

991066

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

991074

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

991080

AURKB
Aurora kinase B

1

3

High-throughput

0.479

High

991081

FXL20
F-box/LRR-repeat protein 20

1

4

Small-scale

0.479

High

991086

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

991088

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.479

High

991099

KDM4C
Lysine-specific demethylase 4C

1

2

Small-scale

0.479

High

991104

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

991106

LATS2
Serine/threonine-protein kinase LATS2

1

3

High-throughput

0.479

High

991108

DCA13
DDB1- and CUL4-associated factor 13

1

2

High-throughput

0.479

High

991116

KS6B2
Ribosomal protein S6 kinase beta-2

1

5

High-throughput

0.479

High

991118

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

991120

DS13B
Dual specificity protein phosphatase 13B

1

4

High-throughput

0.479

High

991121

BRPF3
Bromodomain and PHD finger-containing protein 3

1

2

High-throughput

0.479

High

991125

FBW1A
F-box/WD repeat-containing protein 1A

1

1

High-throughput

0.479

High

991127

E41L3
Band 4.1-like protein 3

1

1

High-throughput

0.479

High

991137

MAFB
Transcription factor MafB

1

3

High-throughput

0.479

High

991138

DUS10
Dual specificity protein phosphatase 10

1

4

High-throughput

0.479

High

991113

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

1

High-throughput

0.470

High

991076

CBP
CREB-binding protein

1

0

Small-scale

0.460

High

159601

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

194122

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

272054

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

319646

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

413581

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

767925

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

884307

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

907368

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.458

High

984061

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.458

High

986327

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

987517

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.458

High

991020

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

991021

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

0

Small-scale

0.458

High

991039

DCAF6
DDB1- and CUL4-associated factor 6

1

0

High-throughput

0.458

High

991048

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

991053

DET1
DET1 homolog

1

0

High-throughput

0.458

High

991069

MCPH1
Microcephalin

1

0

High-throughput

0.458

High

991073

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

991077

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.458

High

991083

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

991085

CIC
Protein capicua homolog

1

0

High-throughput

0.458

High

991087

NECD
Necdin

1

0

High-throughput

0.458

High

991089

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

991093

DERL1
Derlin-1

1

0

Small-scale

0.458

High

991101

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

991105

ANLN
Anillin

1

0

High-throughput

0.458

High

991111

WSB2
WD repeat and SOCS box-containing protein 2

1

0

High-throughput

0.458

High

991122

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

116971

J3KPD3
RNA-binding protein 7

1

8

High-throughput

0.445

High

181083

AXIN1
Axin-1

1

1

Small-scale

0.445

High

429692

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

529574

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

934430

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.445

High

991042

CE170
Centrosomal protein of 170 kDa

1

1

High-throughput

0.445

High

991056

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

1

Small-scale

0.445

High

991058

KSR1
Kinase suppressor of Ras 1

1

7

Small-scale

0.445

High

991102

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

991115

PI4KB
Phosphatidylinositol 4-kinase beta

1

1

Small-scale

0.445

High

587615

DESP
Desmoplakin

1

5

High-throughput

0.437

High

640142

EPHA1
Ephrin type-A receptor 1

1

1

High-throughput

0.437

High

991022

PWP1
Periodic tryptophan protein 1 homolog

1

1

High-throughput

0.437

High

991036

ANR55
Ankyrin repeat domain-containing protein 55

1

2

High-throughput

0.437

High

991043

OTUD1
OTU domain-containing protein 1

1

1

High-throughput

0.437

High

991050

FBX42
F-box only protein 42

1

5

High-throughput

0.437

High

991051

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

991052

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.437

High

991064

FBXL6
F-box/LRR-repeat protein 6

1

4

High-throughput

0.437

High

991100

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

244955

KATIP
Katanin-interacting protein

1

0

High-throughput

0.426

High

294688

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

991110

SPHK1
Sphingosine kinase 1

1

0

Small-scale

0.426

High

377307

VIP
VIP peptides [Cleaved into: Intestinal peptide PHV-42

1

1

High-throughput

0.407

High

991016

S20A2
Sodium-dependent phosphate transporter 2

1

2

High-throughput

0.407

High

991057

S22A9
Organic anion transporter 7

1

1

High-throughput

0.407

High

991072

S20A1
Sodium-dependent phosphate transporter 1

1

2

High-throughput

0.407

High

991114

HACD3
Very-long-chain

2

0

High-throughput

0.305

High

991078

K1143
Uncharacterized protein KIAA1143

1

0

High-throughput

0.279

Low

352758

F107A
Actin-associated protein FAM107A

1

0

High-throughput

0.269

Low

991068

Q8NE08
COL25A1 protein

1

0

High-throughput

0.268

Low

105724

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

257430

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

411714

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

991009

ZXDA
Zinc finger X-linked protein ZXDA

1

0

Small-scale

0.249

Low

991027

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

991035

ZN750
Zinc finger protein 750

1

0

Small-scale

0.249

Low

991045

TENS2
Tensin-2

1

0

High-throughput

0.249

Low

991067

FSAF1
40S small subunit processome assembly factor 1

1

0

High-throughput

0.249

Low

991109

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

991130

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

230172

S28A2
Sodium/nucleoside cotransporter 2

1

0

High-throughput

0.232

Low

991084

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low

991096

TX101
Testis-expressed protein 101

1

0

High-throughput

0.232

Low

991117

SL9A2
Sodium/hydrogen exchanger 2

1

0

High-throughput

0.232

Low

991136

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025