HitPredict

Interactor 1: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Interactor 2: SH3R1 (Q7Z6J0)
E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2)
Gene: SH3RF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	32296183
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 533 Hs			1 888
+	Hs
		209043 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		NCK2_HUMAN (101-330): 2.72e-37: 146: 17.26
+	Hs
		1024144 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		STAM1_HUMAN (420-699): 2.16e-25: 113: 12.84
+	Hs
		277055 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		STAM2_HUMAN (436-755): 1.43e-22: 104: 13.81
+	Mm
		292686 LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98		GRAP2_MOUSE (98-188): 5.58e-22: 99.8: 23.91
+	Hs
		1024146 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		SH3G2_HUMAN (371-504): 2.89e-14: 77.2: 17.91
+	Hs
		275193 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		GRAP2_HUMAN (835-887): 3.61e-12: 70.6: 28.30
+	Hs
		209129 BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28		NCK2_HUMAN (101-330): 2.72e-37: 146: 17.26
+	Hs
		235523 TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32		VINEX_HUMAN (245-888): 2.14e-32: 136: 13.37
+	Mm
		292689 BLNK_MOUSE (78-520): 1.72e-37: 145: 23.27		GRAP2_MOUSE (98-188): 5.58e-22: 99.8: 23.91
+	Hs
		203191 SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71		VINEX_HUMAN (245-888): 2.14e-32: 136: 13.37
+	Hs
		235595 TENS1_HUMAN (85-512): 1.44e-22: 104: 14.61		VINEX_HUMAN (245-888): 2.14e-32: 136: 13.37
+	Ce
		110116 TENSH_CAEEL (185-512): 1.26e-33: 138: 15.95		Q9U2T9_CAEEL (405-886): 2.91e-17: 89.3: 14.40
+	Mm
		1143916 BLNK_MOUSE (78-520): 1.72e-37: 145: 23.27		SH3G1_MOUSE (234-509): 2.98e-15: 80.7: 13.04
+	Hs
		1261033 BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28		CD2AP_HUMAN (764-888): 1.62e-12: 73.3: 30.47
+	Hs
		275217 BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28		GRAP2_HUMAN (835-887): 3.61e-12: 70.6: 28.30
+	Mm
		1246941 BLNK_MOUSE (78-520): 1.72e-37: 145: 23.27		SH3K1_MOUSE (838-888): 1.04e-09: 64.5: 35.29
+	Hs
		203192 SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71		SRBS2_HUMAN (428-502): 2.43e-22: 105: 44.32
+	Hs
		203246 SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71		SH3Y1_HUMAN (734-885): 2.77e-14: 77.2: 16.23
+	Hs
		203230 SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71		SH319_HUMAN (133-192): 4.35e-13: 75.4: 40.00
+	Hs
		203228 SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71		ITSN1_HUMAN (551-888): 1.75e-12: 73.7: 12.83