Protein: SP100
Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)

Gene: SP100
Organism: Homo sapiens
Interactions: 202
UniProt ID: P23497

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000723 - telomere maintenance
GO:0000781 - chromosome, telomeric region
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

481094

HMGB1
High mobility group protein B1

7

14

High-throughput

0.960

High

659167

SP100
Nuclear autoantigen Sp-100

6

18

Small-scale

0.953

High

659170

HMGB2
High mobility group protein B2

4

18

High-throughput

0.886

High

659178

CBX5
Chromobox protein homolog 5

9

20

Small-scale

0.755

High

659204

UBC9
SUMO-conjugating enzyme UBC9

7

8

Small-scale

0.748

High

659202

SUMO1
Small ubiquitin-related modifier 1

6

12

Small-scale

0.740

High

659219

CBX3
Chromobox protein homolog 3

5

20

Small-scale

0.721

High

659196

SUMO2
Small ubiquitin-related modifier 2

4

12

Small-scale

0.692

High

659174

ACTN2
Alpha-actinin-2

3

5

High-throughput

0.683

High

659267

GIPC2
PDZ domain-containing protein GIPC2

4

0

High-throughput

0.668

High

659209

CBX1
Chromobox protein homolog 1

3

20

Small-scale

0.661

High

659319

T3JAM
TRAF3-interacting JNK-activating modulator

4

9

High-throughput

0.637

High

413202

P53
Cellular tumor antigen p53

1

8

High-throughput

0.618

High

659289

PKP2
Plakophilin-2

1

17

High-throughput

0.618

High

659194

SUMO3
Small ubiquitin-related modifier 3

2

12

Small-scale

0.611

High

659264

SNIP1
Smad nuclear-interacting protein 1

2

3

High-throughput

0.606

High

659292

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

1

High-throughput

0.606

High

659185

RBP2
E3 SUMO-protein ligase RanBP2

2

12

Small-scale

0.602

High

659171

PML
Protein PML

2

13

Small-scale

0.586

High

659294

HEMGN
Hemogen

2

2

Small-scale

0.576

High

659288

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

Small-scale

0.573

High

659227

RBM39
RNA-binding protein 39

1

12

High-throughput

0.573

High

659273

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

16

High-throughput

0.573

High

659281

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

7

High-throughput

0.573

High

659320

AMOL2
Angiomotin-like protein 2

1

9

High-throughput

0.573

High

659328

DNM3A
DNA

1

1

High-throughput

0.573

High

659192

TERF1
Telomeric repeat-binding factor 1

1

5

High-throughput

0.552

High

659233

TERF2
Telomeric repeat-binding factor 2

1

5

High-throughput

0.552

High

659308

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.552

High

519333

MYB
Transcriptional activator Myb

1

4

High-throughput

0.541

High

659214

CREM
cAMP-responsive element modulator

1

8

High-throughput

0.541

High

659225

TRI29
Tripartite motif-containing protein 29

1

5

High-throughput

0.541

High

212156

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

7

High-throughput

0.536

High

228174

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

2

High-throughput

0.536

High

541833

TOP1
DNA topoisomerase 1

1

9

High-throughput

0.536

High

655068

SFPQ
Splicing factor, proline- and glutamine-rich

1

7

High-throughput

0.536

High

659168

TYY1
Transcriptional repressor protein YY1

1

8

High-throughput

0.536

High

659169

DDX6
Probable ATP-dependent RNA helicase DDX6

1

15

High-throughput

0.536

High

659176

RS19
Small ribosomal subunit protein eS19

1

5

High-throughput

0.536

High

659179

CRKL
Crk-like protein

1

4

High-throughput

0.536

High

659180

RL29
Large ribosomal subunit protein eL29

1

1

High-throughput

0.536

High

659181

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

5

High-throughput

0.536

High

659182

KC1D
Casein kinase I isoform delta

1

5

High-throughput

0.536

High

659184

RBM25
RNA-binding protein 25

1

16

High-throughput

0.536

High

659189

MECP2
Methyl-CpG-binding protein 2

1

19

High-throughput

0.536

High

659193

MFAP1
Microfibrillar-associated protein 1

1

2

High-throughput

0.536

High

659198

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

10

High-throughput

0.536

High

659199

RL23A
Large ribosomal subunit protein uL23

1

3

High-throughput

0.536

High

659200

RL8
Large ribosomal subunit protein uL2

1

4

High-throughput

0.536

High

659203

IF5A1
Eukaryotic translation initiation factor 5A-1

1

3

High-throughput

0.536

High

659222

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

20

High-throughput

0.536

High

659230

NONO
Non-POU domain-containing octamer-binding protein

1

10

High-throughput

0.536

High

659237

LSM12
Protein LSM12

1

1

High-throughput

0.536

High

659241

FA76B
Protein FAM76B

1

2

High-throughput

0.536

High

659249

MEPCE
7SK snRNA methylphosphate capping enzyme

1

3

High-throughput

0.536

High

659250

NUFP2
FMR1-interacting protein NUFIP2

1

3

High-throughput

0.536

High

659252

DDX42
ATP-dependent RNA helicase DDX42

1

10

High-throughput

0.536

High

659257

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

5

High-throughput

0.536

High

659258

PR38A
Pre-mRNA-splicing factor 38A

1

1

High-throughput

0.536

High

659268

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

8

High-throughput

0.536

High

659270

PSPC1
Paraspeckle component 1

1

9

High-throughput

0.536

High

659283

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

9

High-throughput

0.536

High

659284

FIZ1
Flt3-interacting zinc finger protein 1

1

2

High-throughput

0.536

High

659287

POP1
Ribonucleases P/MRP protein subunit POP1

1

2

High-throughput

0.536

High

659295

NUF2
Kinetochore protein Nuf2

1

8

High-throughput

0.536

High

659296

GTPB4
GTP-binding protein 4

1

8

High-throughput

0.536

High

659298

NSRP1
Nuclear speckle splicing regulatory protein 1

1

8

High-throughput

0.536

High

659307

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

4

High-throughput

0.536

High

659322

NOP16
Nucleolar protein 16

1

1

High-throughput

0.536

High

659326

MAFB
Transcription factor MafB

1

11

High-throughput

0.536

High

577407

ETS1
Protein C-ets-1

1

17

Small-scale

0.529

High

659280

ZC21A
Zinc finger C2HC domain-containing protein 1A

1

1

High-throughput

0.523

High

659272

H1X
Histone H1.10

1

2

High-throughput

0.515

High

659175

SYUA
Alpha-synuclein

1

2

High-throughput

0.515

High

659240

Q59GP6
Polyhomeotic-like protein 1 variant

1

20

High-throughput

0.515

High

659329

V9HWG0
Epididymis luminal protein 25

1

20

High-throughput

0.515

High

659255

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.513

High

659278

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.513

High

659315

C8AP2
CASP8-associated protein 2

1

0

Small-scale

0.506

High

659242

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.501

High

659245

NIPBL
Nipped-B-like protein

1

14

Small-scale

0.501

High

659309

SENP1
Sentrin-specific protease 1

1

6

Small-scale

0.501

High

659256

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

4

High-throughput

0.494

High

659327

ZN706
Zinc finger protein 706

1

0

High-throughput

0.493

High

659172

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.489

High

659217

CKAP4
Cytoskeleton-associated protein 4

1

13

High-throughput

0.489

High

659269

ATX2L
Ataxin-2-like protein

1

20

High-throughput

0.489

High

659290

CHOLN
Protein cholesin

1

2

High-throughput

0.489

High

659291

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.489

High

633358

MX1
Interferon-induced GTP-binding protein Mx1

1

6

Small-scale

0.481

High

659207

PHC1
Polyhomeotic-like protein 1

1

14

High-throughput

0.481

High

659275

CBP
CREB-binding protein

1

20

Small-scale

0.481

High

96613

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.479

High

161948

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

7

High-throughput

0.479

High

174307

ZN609
Zinc finger protein 609

1

12

High-throughput

0.479

High

177434

ZN536
Zinc finger protein 536

1

7

High-throughput

0.479

High

178470

TBX3
T-box transcription factor TBX3

1

10

High-throughput

0.479

High

214275

MSI1H
RNA-binding protein Musashi homolog 1

1

18

High-throughput

0.479

High

228966

AKAP8
A-kinase anchor protein 8

1

7

High-throughput

0.479

High

245671

GANP
Germinal-center associated nuclear protein

1

11

High-throughput

0.479

High

274468

DNJB6
DnaJ homolog subfamily B member 6

1

8

High-throughput

0.479

High

277559

H2AY
Core histone macro-H2A.1

1

20

High-throughput

0.479

High

288221

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

4

High-throughput

0.479

High

289116

PRDM1
PR domain zinc finger protein 1

1

9

Small-scale

0.479

High

418837

H2A1B
Histone H2A type 1-B/E

1

20

High-throughput

0.479

High

517516

GLI3
Transcriptional activator GLI3

1

10

High-throughput

0.479

High

521544

H14
Histone H1.4

1

9

High-throughput

0.479

High

539291

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

8

High-throughput

0.479

High

595943

H12
Histone H1.2

1

9

High-throughput

0.479

High

642086

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

1

High-throughput

0.479

High

643690

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

3

High-throughput

0.479

High

655702

TBG1
Tubulin gamma-1 chain

1

9

High-throughput

0.479

High

659173

MYH9
Myosin-9

1

3

High-throughput

0.479

High

659177

GATA4
Transcription factor GATA-4

1

13

High-throughput

0.479

High

659183

CTCF
Transcriptional repressor CTCF

1

8

High-throughput

0.479

High

659186

TAF6
Transcription initiation factor TFIID subunit 6

1

2

High-throughput

0.479

High

659187

RT29
Small ribosomal subunit protein mS29

1

4

High-throughput

0.479

High

659190

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.479

High

659195

FOXL2
Forkhead box protein L2

1

20

Small-scale

0.479

High

659197

DCAF7
DDB1- and CUL4-associated factor 7

1

20

High-throughput

0.479

High

659201

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

14

High-throughput

0.479

High

659206

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

659208

RAE1L
mRNA export factor RAE1

1

20

High-throughput

0.479

High

659210

RL19
Large ribosomal subunit protein eL19

1

3

High-throughput

0.479

High

659212

FLI1
Friend leukemia integration 1 transcription factor

1

17

Small-scale

0.479

High

659213

IRF8
Interferon regulatory factor 8

1

5

Small-scale

0.479

High

659215

TF65
Transcription factor p65

1

16

High-throughput

0.479

High

659218

FOXC1
Forkhead box protein C1

1

20

High-throughput

0.479

High

659220

TBX2
T-box transcription factor TBX2

1

10

High-throughput

0.479

High

659221

BIRC2
Baculoviral IAP repeat-containing protein 2

1

4

High-throughput

0.479

High

659223

PEX6
Peroxisomal ATPase PEX6

1

4

High-throughput

0.479

High

659224

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

High-throughput

0.479

High

659226

RCN2
Reticulocalbin-2

1

6

High-throughput

0.479

High

659232

TAF5
Transcription initiation factor TFIID subunit 5

1

20

High-throughput

0.479

High

659234

IF16
Gamma-interferon-inducible protein 16

1

5

High-throughput

0.479

High

659235

ZN827
Zinc finger protein 827

1

5

High-throughput

0.479

High

659236

RGPA2
Ral GTPase-activating protein subunit alpha-2

1

4

High-throughput

0.479

High

659238

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

2

High-throughput

0.479

High

659247

BCOR
BCL-6 corepressor

1

20

High-throughput

0.479

High

659248

H32
Histone H3.2

1

20

High-throughput

0.479

High

659251

ZFHX4
Zinc finger homeobox protein 4

1

13

High-throughput

0.479

High

659253

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

659259

MLKL
Mixed lineage kinase domain-like protein

1

3

High-throughput

0.479

High

659260

AFG2A
ATPase family gene 2 protein homolog A

1

4

High-throughput

0.479

High

659261

ZN740
Zinc finger protein 740

1

16

High-throughput

0.479

High

659262

COP1
E3 ubiquitin-protein ligase COP1

1

20

High-throughput

0.479

High

659265

G45IP
Large ribosomal subunit protein mL64

1

3

High-throughput

0.479

High

659271

S39A7
Zinc transporter SLC39A7

1

1

High-throughput

0.479

High

659274

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

659277

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

4

High-throughput

0.479

High

659279

PTCD3
Small ribosomal subunit protein mS39

1

4

High-throughput

0.479

High

659285

RSF1
Remodeling and spacing factor 1

1

20

High-throughput

0.479

High

659286

HTF4
Transcription factor 12

1

6

High-throughput

0.479

High

659293

GNL3
Guanine nucleotide-binding protein-like 3

1

9

High-throughput

0.479

High

659297

BC11B
B-cell lymphoma/leukemia 11B

1

5

High-throughput

0.479

High

659299

BC11A
BCL11 transcription factor A

1

3

High-throughput

0.479

High

659300

HIPK2
Homeodomain-interacting protein kinase 2

1

19

Small-scale

0.479

High

659301

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.479

High

659302

ZN768
Zinc finger protein 768

1

3

High-throughput

0.479

High

659304

ANLN
Anillin

1

6

High-throughput

0.479

High

659305

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

1

High-throughput

0.479

High

659306

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

1

7

High-throughput

0.479

High

659311

RCOR3
REST corepressor 3

1

20

High-throughput

0.479

High

659312

MYEF2
Myelin expression factor 2

1

9

High-throughput

0.479

High

659313

TRPS1
Zinc finger transcription factor Trps1

1

17

High-throughput

0.479

High

659314

RCOR1
REST corepressor 1

1

20

High-throughput

0.479

High

659316

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.479

High

659317

AKP8L
A-kinase anchor protein 8-like

1

7

High-throughput

0.479

High

659318

TRI33
E3 ubiquitin-protein ligase TRIM33

1

17

High-throughput

0.479

High

659321

ZN281
Zinc finger protein 281

1

9

High-throughput

0.479

High

659323

CHTOP
Chromatin target of PRMT1 protein

1

3

High-throughput

0.479

High

659324

SALL2
Sal-like protein 2

1

12

High-throughput

0.479

High

659325

DCAF1
DDB1- and CUL4-associated factor 1

1

20

High-throughput

0.479

High

369018

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.458

High

659188

GALK1
Galactokinase

1

0

High-throughput

0.458

High

659211

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.458

High

659216

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

107793

SUMO5
Small ubiquitin-related modifier 5

1

12

High-throughput

0.457

High

659243

GPTC4
G patch domain-containing protein 4

1

1

High-throughput

0.445

High

425770

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

2

High-throughput

0.437

High

554775

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

4

High-throughput

0.437

High

659205

3BP2
SH3 domain-binding protein 2

1

6

High-throughput

0.437

High

659228

GSE1
Genetic suppressor element 1

1

3

High-throughput

0.437

High

659231

RCN1
Reticulocalbin-1

1

3

High-throughput

0.437

High

659239

SWAHC
Ankyrin repeat domain-containing protein SOWAHC

1

9

High-throughput

0.437

High

659246

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.437

High

659254

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.437

High

659266

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

1

High-throughput

0.437

High

659276

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.437

High

659282

SFXN2
Sideroflexin-2

1

1

High-throughput

0.437

High

659303

FBSL
Fibrosin-1-like protein

1

4

High-throughput

0.437

High

659310

PHRF1
PHD and RING finger domain-containing protein 1

1

20

High-throughput

0.437

High

659229

RTP5
Receptor-transporting protein 5

3

0

High-throughput

0.352

High

317796

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.279

Low

659244

USPL1
SUMO-specific isopeptidase USPL1

1

0

Small-scale

0.261

Low

67100

CP096
Uncharacterized protein C16orf96

1

0

High-throughput

0.249

Low

162086

ACOT8
Acyl-coenzyme A thioesterase 8

1

0

High-throughput

0.249

Low

176442

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.249

Low

228801

SCO2
Protein SCO2 homolog, mitochondrial

1

0

High-throughput

0.249

Low

659191

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

659263

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025