Protein: SOX15
Transcription factor SOX-15 (Protein SOX-12) (Protein SOX-20) (SRY-box transcription factor 15)

Gene: SOX15
Organism: Homo sapiens
Interactions: 130
UniProt ID: O60248

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

239937

TFAM
Transcription factor A, mitochondrial

1

19

High-throughput

0.646

High

239919

PO2F1
POU domain, class 2, transcription factor 1

1

20

High-throughput

0.618

High

239966

PB1
Protein polybromo-1

1

20

High-throughput

0.618

High

239986

CIC
Protein capicua homolog

1

19

High-throughput

0.618

High

240002

HM20A
High mobility group protein 20A

1

20

High-throughput

0.618

High

239920

HXB9
Homeobox protein Hox-B9

2

20

High-throughput

0.614

High

154920

BHE40
Class E basic helix-loop-helix protein 40

1

2

High-throughput

0.573

High

239984

HSFY1
Heat shock transcription factor, Y-linked

1

2

High-throughput

0.573

High

239914

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.561

High

239918

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.541

High

239911

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

16

High-throughput

0.536

High

239953

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

13

High-throughput

0.536

High

239975

RT27
Small ribosomal subunit protein mS27

1

1

High-throughput

0.536

High

239988

DDX50
ATP-dependent RNA helicase DDX50

1

16

High-throughput

0.536

High

239995

DDX24
ATP-dependent RNA helicase DDX24

1

15

High-throughput

0.536

High

240008

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

17

High-throughput

0.536

High

142738

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.515

High

239931

CANB1
Calcineurin subunit B type 1

1

1

High-throughput

0.515

High

239946

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.515

High

239921

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.501

High

239956

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.501

High

134981

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

18

High-throughput

0.500

High

239912

P53
Cellular tumor antigen p53

1

8

High-throughput

0.500

High

239913

LA
Lupus La protein

1

9

High-throughput

0.500

High

239916

TOP1
DNA topoisomerase 1

1

6

High-throughput

0.500

High

239925

NOP2
28S rRNA

1

2

High-throughput

0.500

High

239930

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.500

High

239943

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

5

High-throughput

0.500

High

239947

ILF2
Interleukin enhancer-binding factor 2

1

11

High-throughput

0.500

High

239951

PWP1
Periodic tryptophan protein 1 homolog

1

20

High-throughput

0.500

High

239952

NOG2
Nucleolar GTP-binding protein 2

1

4

High-throughput

0.500

High

239959

HP1B3
Heterochromatin protein 1-binding protein 3

1

1

High-throughput

0.500

High

239963

DHX30
ATP-dependent RNA helicase DHX30

1

11

High-throughput

0.500

High

239969

LS14A
Protein LSM14 homolog A

1

20

High-throughput

0.500

High

239974

NOC3L
Nucleolar complex protein 3 homolog

1

2

High-throughput

0.500

High

239979

RENT1
Regulator of nonsense transcripts 1

1

4

High-throughput

0.500

High

239985

ZN512
Zinc finger protein 512

1

11

High-throughput

0.500

High

239987

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.500

High

239990

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

17

High-throughput

0.500

High

239991

GNL3
Guanine nucleotide-binding protein-like 3

1

4

High-throughput

0.500

High

239994

GTPB4
GTP-binding protein 4

1

6

High-throughput

0.500

High

240001

MOV10
Helicase MOV-10

1

4

High-throughput

0.500

High

240016

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

High-throughput

0.500

High

239907

RL1D1
Ribosomal L1 domain-containing protein 1

1

4

High-throughput

0.489

High

239924

RBM34
RNA-binding protein 34

1

13

High-throughput

0.489

High

239927

RT29
Small ribosomal subunit protein mS29

1

1

High-throughput

0.489

High

239932

RT22
Small ribosomal subunit protein mS22

1

1

High-throughput

0.489

High

239934

RT34
Small ribosomal subunit protein mS34

1

2

High-throughput

0.489

High

239976

RT31
Small ribosomal subunit protein mS31

1

1

High-throughput

0.489

High

239981

PTCD3
Small ribosomal subunit protein mS39

1

1

High-throughput

0.489

High

239989

CHOLN
Protein cholesin

1

2

High-throughput

0.489

High

240006

RBM28
RNA-binding protein 28

1

3

High-throughput

0.489

High

240022

RT23
Small ribosomal subunit protein mS23

1

2

High-throughput

0.489

High

240024

RT18B
Small ribosomal subunit protein mS40

1

1

High-throughput

0.489

High

65660

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

4

High-throughput

0.479

High

138955

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.479

High

154589

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

161380

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

174289

ZN609
Zinc finger protein 609

1

18

High-throughput

0.479

High

194491

KDM6A
Lysine-specific demethylase 6A

1

15

High-throughput

0.479

High

239906

E2F6
Transcription factor E2F6

1

6

High-throughput

0.479

High

239909

EYA4
Protein phosphatase EYA4

1

20

High-throughput

0.479

High

239910

WIZ
Protein Wiz

1

12

High-throughput

0.479

High

239915

ATX1L
Ataxin-1-like

1

11

High-throughput

0.479

High

239917

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

20

High-throughput

0.479

High

239922

CUX1
Homeobox protein cut-like 1

1

20

High-throughput

0.479

High

239926

MNX1
Motor neuron and pancreas homeobox protein 1

1

20

High-throughput

0.479

High

239929

IF6
Eukaryotic translation initiation factor 6

1

1

High-throughput

0.479

High

239936

FOXK1
Forkhead box protein K1

1

20

High-throughput

0.479

High

239938

FLI1
Friend leukemia integration 1 transcription factor

1

17

High-throughput

0.479

High

239939

TFAP4
Transcription factor AP-4

1

2

High-throughput

0.479

High

239940

SATB1
DNA-binding protein SATB1

1

13

High-throughput

0.479

High

239941

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.479

High

239942

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

239944

TLE5
TLE family member 5

1

18

High-throughput

0.479

High

239945

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

239948

FOXC1
Forkhead box protein C1

1

20

High-throughput

0.479

High

239949

GPS2
G protein pathway suppressor 2

1

3

High-throughput

0.479

High

239950

KRR1
KRR1 small subunit processome component homolog

1

1

High-throughput

0.479

High

239955

RRP5
Protein RRP5 homolog

1

6

High-throughput

0.479

High

239957

NCOA2
Nuclear receptor coactivator 2

1

20

High-throughput

0.479

High

239958

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

9

High-throughput

0.479

High

239960

ARID2
AT-rich interactive domain-containing protein 2

1

20

High-throughput

0.479

High

239961

BCOR
BCL-6 corepressor

1

20

High-throughput

0.479

High

239962

PAXI1
PAX-interacting protein 1

1

20

High-throughput

0.479

High

239964

TRM1L
tRNA

1

1

High-throughput

0.479

High

239965

LDB1
LIM domain-binding protein 1

1

5

High-throughput

0.479

High

239967

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

239970

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

19

High-throughput

0.479

High

239971

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

239972

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

20

High-throughput

0.479

High

239977

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

239978

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

239980

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

1

6

High-throughput

0.479

High

239983

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

12

High-throughput

0.479

High

239992

KIFC1
Kinesin-like protein KIFC1

1

4

High-throughput

0.479

High

239993

SSBP3
Single-stranded DNA-binding protein 3

1

15

High-throughput

0.479

High

239996

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

3

High-throughput

0.479

High

239997

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.479

High

239998

ZN644
Zinc finger protein 644

1

15

High-throughput

0.479

High

239999

ZN703
Zinc finger protein 703

1

9

High-throughput

0.479

High

240000

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

10

High-throughput

0.479

High

240003

SSF1
Suppressor of SWI4 1 homolog

1

1

High-throughput

0.479

High

240007

DDX56
Probable ATP-dependent RNA helicase DDX56

1

16

High-throughput

0.479

High

240009

NOP53
Ribosome biogenesis protein NOP53

1

2

High-throughput

0.479

High

240010

TRPS1
Zinc finger transcription factor Trps1

1

20

High-throughput

0.479

High

240011

SIX4
Homeobox protein SIX4

1

18

High-throughput

0.479

High

240012

MRT4
mRNA turnover protein 4 homolog

1

4

High-throughput

0.479

High

240013

ZN608
Zinc finger protein 608

1

14

High-throughput

0.479

High

240014

PRR12
Proline-rich protein 12

1

20

High-throughput

0.479

High

240015

SATB2
DNA-binding protein SATB2

1

13

High-throughput

0.479

High

240019

ZN281
Zinc finger protein 281

1

14

High-throughput

0.479

High

240023

NCOR2
Nuclear receptor corepressor 2

1

20

High-throughput

0.479

High

240025

NCOA3
Nuclear receptor coactivator 3

1

20

High-throughput

0.479

High

240026

ZHX2
Zinc fingers and homeoboxes protein 2

1

20

High-throughput

0.479

High

240004

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.458

High

239923

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.457

High

239928

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

2

High-throughput

0.457

High

239933

RT05
Small ribosomal subunit protein uS5m

1

3

High-throughput

0.457

High

239935

RT09
Small ribosomal subunit protein uS9m

1

5

High-throughput

0.457

High

239973

BRX1
Ribosome biogenesis protein BRX1 homolog

1

3

High-throughput

0.457

High

240005

ATD3A
ATPase family AAA domain-containing protein 3A

1

7

High-throughput

0.457

High

240018

RT07
Small ribosomal subunit protein uS7m

1

2

High-throughput

0.457

High

239908

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.437

High

239954

GSE1
Genetic suppressor element 1

1

5

High-throughput

0.437

High

239968

KRI1
Protein KRI1 homolog

1

2

High-throughput

0.437

High

239982

DDX27
Probable ATP-dependent RNA helicase DDX27

1

12

High-throughput

0.437

High

240020

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.437

High

240021

RT16
Small ribosomal subunit protein bS16m

1

1

High-throughput

0.437

High

240017

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025