HitPredict

Interactor 1: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Interactor 2: KBTB4 (Q9NVX7)
Kelch repeat and BTB domain-containing protein 4 (BTB and kelch domain-containing protein 4)
Gene: KBTBD4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.50	0.549

Property	Details
Experiments	35379950, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 414 Hs			1 518
+	Hs
		516716 PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95		KBTB4_HUMAN (1-518): 1.75e-117: 358: 100.00
+	Dm
		822823 RB27C_DROME (99-400): 4.23e-73: 236: 28.17		KELC_DROME (209-478): 2.96e-43: 166: 16.73
+	Hs
		1026020 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		KLH20_HUMAN (188-429): 4.77e-29: 123: 17.89
+	Hs
		1025800 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		KLH17_HUMAN (265-429): 1.29e-27: 118: 17.16
+	Hs
		1025776 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		KLH26_HUMAN (172-426): 3.12e-22: 102: 15.87
+	Hs
		1025841 TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00		KLH36_HUMAN (211-428): 4.11e-22: 101: 19.91
+	Dm
		432489 ROA1_DROME (179-271): 1.97e-16: 82.1: 24.24		KELC_DROME (209-478): 2.96e-43: 166: 16.73