Protein: CLH2
Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22)

Gene: CLH2, CLTCL1
Organism: Homo sapiens
Interactions: 180
UniProt ID: P53675

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0005198 - structural molecule activity
GO:0005770 - late endosome
GO:0005802 - trans-Golgi network
GO:0005819 - spindle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

922420

CLH1
Clathrin heavy chain 1

5

7

High-throughput

0.915

High

483312

CLCB
Clathrin light chain B

3

7

High-throughput

0.861

High

483051

CLCA
Clathrin light chain A

3

11

Small-scale

0.839

High

922428

PICAL
Phosphatidylinositol-binding clathrin assembly protein

3

11

High-throughput

0.675

High

340624

STABP
STAM-binding protein

3

3

High-throughput

0.667

High

922432

RAB32
Ras-related protein Rab-32

3

5

High-throughput

0.667

High

922484

STALP
AMSH-like protease

3

3

High-throughput

0.662

High

459253

CATL1
Procathepsin L

3

0

High-throughput

0.638

High

475930

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

3

0

High-throughput

0.638

High

922503

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

3

11

Small-scale

0.633

High

563467

CFTR
Cystic fibrosis transmembrane conductance regulator

2

4

High-throughput

0.628

High

922433

EPN4
Clathrin interactor 1

2

13

High-throughput

0.628

High

260680

CUTA
Protein CutA

2

0

High-throughput

0.602

High

922452

GALT7
N-acetylgalactosaminyltransferase 7

2

0

High-throughput

0.602

High

922522

NOP53
Ribosome biogenesis protein NOP53

2

0

High-throughput

0.602

High

922523

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

2

0

High-throughput

0.602

High

922447

CDC73
Parafibromin

2

1

Small-scale

0.586

High

922423

RL6
Large ribosomal subunit protein eL6

2

0

High-throughput

0.585

High

141750

CCL21
C-C motif chemokine 21

2

1

High-throughput

0.574

High

838523

GRIA3
Glutamate receptor 3

2

2

High-throughput

0.574

High

922439

CCD27
Coiled-coil domain-containing protein 27

2

1

High-throughput

0.574

High

922457

WDR5B
WD repeat-containing protein 5B

2

4

High-throughput

0.574

High

922459

IT70A
Intraflagellar transport protein 70A

2

1

High-throughput

0.574

High

922464

IT70B
Intraflagellar transport protein 70B

2

1

High-throughput

0.574

High

130929

HIP1
Huntingtin-interacting protein 1

1

4

Small-scale

0.568

High

65970

CCD69
Coiled-coil domain-containing protein 69

2

1

High-throughput

0.558

High

324668

HEXI1
Protein HEXIM1

2

1

High-throughput

0.558

High

922533

SNX5
Sorting nexin-5

1

3

Small-scale

0.552

High

379960

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

1

High-throughput

0.552

High

922507

PAAT
ATPase PAAT

2

1

High-throughput

0.549

High

171207

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

1

High-throughput

0.536

High

171685

GAK
Cyclin-G-associated kinase

1

9

High-throughput

0.536

High

174990

SC16A
Protein transport protein Sec16A

1

3

High-throughput

0.536

High

252755

AP180
Clathrin coat assembly protein AP180

1

9

High-throughput

0.536

High

256456

TOM1
Target of Myb1 membrane trafficking protein

1

18

High-throughput

0.536

High

269951

AUXI
Auxilin

1

6

High-throughput

0.536

High

274512

DNJB6
DnaJ homolog subfamily B member 6

1

1

High-throughput

0.536

High

363021

EGFR
Epidermal growth factor receptor

1

7

Small-scale

0.536

High

395745

ESR1
Estrogen receptor

1

3

High-throughput

0.536

High

860669

RS10
Small ribosomal subunit protein eS10

1

4

High-throughput

0.536

High

866622

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.536

High

922416

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

2

High-throughput

0.536

High

922421

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.536

High

922424

TF65
Transcription factor p65

1

4

High-throughput

0.536

High

922430

CUL1
Cullin-1

1

5

High-throughput

0.536

High

922431

CUL3
Cullin-3

1

5

High-throughput

0.536

High

922437

NEDD8
Ubiquitin-like protein NEDD8

1

1

High-throughput

0.536

High

922444

K1C39
Keratin, type I cytoskeletal 39

1

1

High-throughput

0.536

High

922451

CSN6
COP9 signalosome complex subunit 6

1

1

High-throughput

0.536

High

922454

THOC4
THO complex subunit 4

1

1

High-throughput

0.536

High

922456

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

High-throughput

0.536

High

922461

SFPA2
Pulmonary surfactant-associated protein A2

1

1

High-throughput

0.536

High

922473

DDX54
ATP-dependent RNA helicase DDX54

1

4

High-throughput

0.536

High

922477

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.536

High

922478

TP4A1
Protein tyrosine phosphatase type IVA 1

1

6

High-throughput

0.536

High

922482

EDC3
Enhancer of mRNA-decapping protein 3

1

1

High-throughput

0.536

High

922485

EF2KT
Protein-lysine N-methyltransferase EEF2KMT

1

2

High-throughput

0.536

High

922487

MYO19
Unconventional myosin-XIX

1

5

High-throughput

0.536

High

922492

RIOK2
Serine/threonine-protein kinase RIO2

1

2

High-throughput

0.536

High

922520

GTSE1
G2 and S phase-expressed protein 1

1

1

High-throughput

0.536

High

922524

LIMA1
LIM domain and actin-binding protein 1

1

3

High-throughput

0.536

High

922527

RUVB2
RuvB-like 2

1

1

High-throughput

0.536

High

922530

HYOU1
Hypoxia up-regulated protein 1

1

6

High-throughput

0.536

High

922448

LDH6A
L-lactate dehydrogenase A-like 6A

1

2

High-throughput

0.515

High

134443

EF2K
Eukaryotic elongation factor 2 kinase

1

0

High-throughput

0.513

High

421773

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.513

High

866513

RPGP1
Rap1 GTPase-activating protein 1

1

0

High-throughput

0.513

High

922412

GALC
Galactocerebrosidase

1

0

High-throughput

0.513

High

922413

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.513

High

922414

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

922418

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

922427

NDK3
Nucleoside diphosphate kinase 3

1

0

High-throughput

0.513

High

922429

ASAH1
Acid ceramidase

1

0

High-throughput

0.513

High

922446

FXL22
F-box and leucine-rich protein 22

1

0

High-throughput

0.513

High

922458

JAZF1
Juxtaposed with another zinc finger protein 1

1

0

High-throughput

0.513

High

922470

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

1

0

High-throughput

0.513

High

922483

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

922491

CSN8
COP9 signalosome complex subunit 8

1

0

High-throughput

0.513

High

922501

OSBL5
Oxysterol-binding protein-related protein 5

1

0

High-throughput

0.513

High

922512

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.513

High

922513

EXOS3
Exosome complex component RRP40

1

0

High-throughput

0.513

High

922515

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.513

High

922519

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.513

High

922525

PCS1N
ProSAAS

1

0

High-throughput

0.513

High

133233

P2Y10
Putative P2Y purinoceptor 10

1

3

High-throughput

0.489

High

293415

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.489

High

711753

ARI4A
AT-rich interactive domain-containing protein 4A

1

1

High-throughput

0.489

High

922434

ARI5B
AT-rich interactive domain-containing protein 5B

1

1

High-throughput

0.489

High

922438

DREB
Drebrin

1

3

High-throughput

0.489

High

922442

SNPC4
snRNA-activating protein complex subunit 4

1

3

High-throughput

0.489

High

922443

MT21C
Protein-lysine methyltransferase METTL21C

1

3

High-throughput

0.489

High

922462

CFA52
Cilia- and flagella-associated protein 52

1

7

High-throughput

0.489

High

922472

PMFBP
Polyamine-modulated factor 1-binding protein 1

1

4

High-throughput

0.489

High

922480

KCD12
BTB/POZ domain-containing protein KCTD12

1

2

High-throughput

0.489

High

922495

WNK3
Serine/threonine-protein kinase WNK3

1

4

High-throughput

0.489

High

922496

GLIS2
Zinc finger protein GLIS2

1

1

High-throughput

0.489

High

922499

REXO4
RNA exonuclease 4

1

1

High-throughput

0.489

High

922509

LIN7B
Protein lin-7 homolog B

1

5

High-throughput

0.489

High

922521

HPBP1
Hsp70-binding protein 1

1

2

High-throughput

0.489

High

922534

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

791211

SYUA
Alpha-synuclein

1

2

High-throughput

0.481

High

157131

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

169484

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

16

Small-scale

0.479

High

222851

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

330783

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

371549

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

622557

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

High-throughput

0.479

High

861943

YAP1
Transcriptional coactivator YAP1

1

7

High-throughput

0.479

High

922417

H31
Histone H3.1

1

2

High-throughput

0.479

High

922425

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

922426

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.479

High

922436

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

922441

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

922476

STAM1
Signal transducing adapter molecule 1

1

19

Small-scale

0.479

High

922479

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.479

High

922481

SPDLY
Protein Spindly

1

3

High-throughput

0.479

High

922486

AURKB
Aurora kinase B

1

4

High-throughput

0.479

High

922490

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

922502

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

922508

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

922510

PKHA2
Pleckstrin homology domain-containing family A member 2

1

3

Small-scale

0.479

High

922514

ANLN
Anillin

1

1

High-throughput

0.479

High

922528

FBW1A
F-box/WD repeat-containing protein 1A

1

5

High-throughput

0.479

High

349889

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

711070

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

0

High-throughput

0.458

High

920611

ARFP1
Arfaptin-1

1

0

High-throughput

0.458

High

922460

CEP57
Centrosomal protein of 57 kDa

1

0

High-throughput

0.458

High

231554

PRKY
Putative serine/threonine-protein kinase PRKY

1

3

High-throughput

0.445

High

327876

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

11

High-throughput

0.445

High

922415

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

11

High-throughput

0.445

High

922422

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

4

High-throughput

0.445

High

922468

CD177
CD177 antigen

1

2

Small-scale

0.445

High

922497

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

922498

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

11

High-throughput

0.445

High

922500

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

11

High-throughput

0.445

High

922526

RABX5
Rab5 GDP/GTP exchange factor

1

3

High-throughput

0.445

High

353142

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

588286

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

695014

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

767776

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

922449

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

922450

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.437

High

922494

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.437

High

922536

CDY2
Testis-specific chromodomain protein Y 2

1

1

High-throughput

0.437

High

922445

PVRIG
Transmembrane protein PVRIG

3

0

High-throughput

0.347

High

922435

ZN169
Zinc finger protein 169

2

0

High-throughput

0.328

High

922466

VMA12
Vacuolar ATPase assembly protein VMA12

2

0

High-throughput

0.328

High

922467

TTC9B
Tetratricopeptide repeat protein 9B

2

0

High-throughput

0.328

High

922469

SPX3
Sugar phosphate exchanger 3

2

0

High-throughput

0.328

High

922474

TCP1L
T-complex protein 10A homolog 1

2

0

High-throughput

0.328

High

922529

RXLT1
Ribitol-5-phosphate xylosyltransferase 1

2

0

High-throughput

0.328

High

922489

CD006
Uncharacterized protein encoded by LINC01587

2

0

High-throughput

0.318

High

51534

PL8L1
PLAC8-like protein 1

1

0

High-throughput

0.279

Low

248466

O10H2
Olfactory receptor 10H2

1

0

High-throughput

0.279

Low

597792

CRIS2
Cysteine-rich secretory protein 2

1

0

High-throughput

0.279

Low

627900

TCO2
Transcobalamin-2

1

0

High-throughput

0.279

Low

634962

NTF3
Neurotrophin-3

1

0

High-throughput

0.279

Low

922419

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

922440

DB135
Beta-defensin 135

1

0

High-throughput

0.279

Low

922453

T150A
Transmembrane protein 150A

1

0

High-throughput

0.279

Low

922455

PIGZ
GPI alpha-1,2-mannosyltransferase 4

1

0

High-throughput

0.279

Low

922463

FGRL1
Fibroblast growth factor receptor-like 1

1

0

High-throughput

0.279

Low

922465

MESH1
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

1

0

High-throughput

0.279

Low

922475

CCG8
Voltage-dependent calcium channel gamma-8 subunit

1

0

High-throughput

0.279

Low

922488

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.279

Low

922504

SIA7D
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase

1

0

High-throughput

0.279

Low

922505

SPRNG
SREBP regulating gene protein

1

0

High-throughput

0.279

Low

922511

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.279

Low

922516

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.279

Low

922517

GKN1
Gastrokine-1

1

0

High-throughput

0.279

Low

922531

MB212
Protein mab-21-like 2

1

0

High-throughput

0.279

Low

922532

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

0

High-throughput

0.279

Low

922535

HS3S4
Heparan sulfate glucosamine 3-O-sulfotransferase 4

1

0

High-throughput

0.279

Low

576633

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.269

Low

922471

O13A1
Olfactory receptor 13A1

1

0

High-throughput

0.269

Low

922493

APOL5
Apolipoprotein L5

1

0

High-throughput

0.269

Low

922518

CZIB
CXXC motif containing zinc binding protein

1

0

High-throughput

0.269

Low

504868

H2AB2
Histone H2A-Bbd type 2/3

1

0

High-throughput

0.249

Low

653213

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

922506

Q9H8E5
cDNA FLJ13705 fis, clone PLACE2000302

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025