HitPredict

Interactor 1: FADD (Q13158)
FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)
Gene: FADD

Interactor 2: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 21737330, 25939870, 25911380, 26437781, 24098568, 27552911, 27321185, 15659383, 12887920, 29795330, 31046799, 23429285, 9228018, 8681376, 33469115, 19060883, 34839354, 34853447, 35044632, 34591612 and 39 others

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Identification Methods affinity chromatography technology, biochemical, two hybrid, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescent resonance energy transfer, virotrap, two hybrid array
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains DED~DED
Common GO terms GO:0005123 - death receptor binding
GO:0005164 - tumor necrosis factor receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006915 - apoptotic process
and 17 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 208
Hs

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Last updated: 15 Jul 2024