HitPredict

Interactor 1: PAK2 (Q13177)
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]
Gene: PAK2

Interactor 2: SPD2A (Q5TCZ1)
SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)
Gene: SH3PXD2A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16374509
Identification Methods	filter binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 524 Hs			1 1133
+	Hs
		1026931 PAK2_HUMAN (1-524): 0: 538: 100.00		SH3R3_HUMAN (384-1130): 4.05e-32: 137: 11.21
+	Hs
		557677 PAK2_HUMAN (1-524): 0: 538: 100.00		NCK1_HUMAN (272-569): 1.62e-23: 105: 14.64
+	Hs
		1026928 PAK2_HUMAN (1-524): 0: 538: 100.00		SH3R1_HUMAN (314-1130): 5.57e-18: 91.9: 8.98
+	Hs
		209045 PAK2_HUMAN (1-524): 0: 538: 100.00		NCK2_HUMAN (813-1029): 7.64e-17: 85.8: 18.65
+	Hs
		81635 PAK2_HUMAN (1-524): 0: 538: 100.00		B7Z6G2_HUMAN (1077-1131): 1.69e-10: 67.5: 23.21
+	Hs
		1026904 PAK2_HUMAN (1-524): 0: 538: 100.00		ARHG7_HUMAN (744-985): 6.08e-10: 65.5: 14.62
+	Hs
		1026936 PAK2_HUMAN (1-524): 0: 538: 100.00		SH3K1_HUMAN (270-877): 2.48e-09: 63.6: 11.75
+	Hs
		557676 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		NCK1_HUMAN (272-569): 1.62e-23: 105: 14.64
+	Mm
		292046 PAK1_MOUSE (1-523): 1.84e-167: 486: 73.35		NCK1_MOUSE (272-569): 2.55e-23: 105: 14.02
+	Hs
		277606 PAK3_HUMAN (1-523): 8.9e-162: 472: 71.71		ITSN1_HUMAN (765-1133): 1.87e-22: 106: 11.47
+	Hs
		277595 PAK3_HUMAN (1-523): 8.9e-162: 472: 71.71		NCK1_HUMAN (272-569): 1.62e-23: 105: 14.64
+	Hs
		209044 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		NCK2_HUMAN (813-1029): 7.64e-17: 85.8: 18.65
+	Hs
		537638 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		NCF1_HUMAN (414-661): 2.59e-14: 78.2: 15.50
+	Rn
		223051 PAK1_RAT (1-523): 2.1e-169: 491: 75.14		ARHG7_RAT (162-776): 2.15e-12: 73.2: 8.78
+	Hs
		1026158 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		ARHG7_HUMAN (744-985): 6.08e-10: 65.5: 14.62
+	Hs
		1026202 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		SH3K1_HUMAN (270-877): 2.48e-09: 63.6: 11.75
+	Mm
		292047 PAK1_MOUSE (1-523): 1.84e-167: 486: 73.35		ARHG7_MOUSE (778-1042): 8.56e-09: 62.1: 14.39
+	Hs
		277605 PAK3_HUMAN (1-523): 8.9e-162: 472: 71.71		ARHG7_HUMAN (744-985): 6.08e-10: 65.5: 14.62
+	Mm
		1142068 PAK3_MOUSE (1-523): 1.14e-162: 475: 71.35		ARHG7_MOUSE (778-1042): 8.56e-09: 62.1: 14.39
+	Ce
		1089181 PK1_CAEEL (9-522): 1.29e-137: 411: 52.21		Q95PW9_CAEEL (161-330): 7.9e-15: 80: 23.60